Nitric oxide and the pathogenesis of heart muscle disease

Nitric oxide: physiology, pathophysiology, and pharmacology.

1991 • 15,563 citations

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor

1987 • 10,774 citations

Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide.

1990 • 7,068 citations

The L-Arginine-Nitric Oxide Pathway

1993 • 6,737 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

Negative Inotropic Effects of Cytokines on the Heart Mediated by Nitric Oxide

1992 • 1,635 citations

EFFECTS OF ENDOTHELIUM-DERIVED NITRIC OXIDE ON PERIPHERAL ARTERIOLAR TONE IN MAN

1989 • 1,625 citations

Macrophage oxidation of L-arginine to nitrite and nitrate: nitric oxide is an intermediate

1988 • 1,622 citations

ENDOGENOUS NITRIC OXIDE INHIBITS HUMAN PLATELET ADHESION TO VASCULAR ENDOTHELIUM

1987 • 1,450 citations

The anti‐aggregating properties of vascular endothelium: interactions between prostacyclin and nitric oxide

1987 • 1,171 citations

Mammalian nitrate biosynthesis: mouse macrophages produce nitrite and nitrate in response to Escherichia coli lipopolysaccharide.

1985 • 1,146 citations

Glucocorticoids inhibit the expression of an inducible, but not the constitutive, nitric oxide synthase in vascular endothelial cells.

1990 • 1,117 citations

The Cardiovascular Response of Normal Humans to the Administration of Endotoxin

1989 • 1,096 citations

Endothelial nitric oxide synthase: molecular cloning and characterization of a distinct constitutive enzyme isoform.

1992 • 1,004 citations

Purification and characterization of particulate endothelium-derived relaxing factor synthase from cultured and native bovine aortic endothelial cells.

1991 • 982 citations

L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells.

1987 • 958 citations

Agonist-induced endothelium-dependent relaxation in rat thoracic aorta may be mediated through cGMP.

1983 • 949 citations

Management of patients with intramural hematoma of the thoracic aorta.

1993 • 896 citations

Molecular cloning and functional expression of an inducible nitric oxide synthase from a murine macrophage cell line.

1992 • 877 citations

Effect of nitric oxide synthase inhibitors on hypotension in patients with septic shock

1991 • 873 citations

Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes.

1993 • 845 citations

Isoforms of nitric oxide synthase Characterization and purification from different cell types

1991 • 827 citations

Comparative pharmacology of endothelium‐derived relaxing factor, nitric oxide and prostacyclin in platelets

1987 • 824 citations

Purification and characterization of the cytokine-induced macrophage nitric oxide synthase: an FAD- and FMN-containing flavoprotein.

1991 • 812 citations

Viral myocarditis. A review.

1980 • 810 citations

Report of the WHO/ISFC task force on the definition and classification of cardiomyopathies.

1980 • 731 citations

Induction of nitrite/nitrate synthesis in murine macrophages by BCG infection, lymphokines, or interferon-gamma.

1987 • 722 citations

Production of hydroxyl radicals from the simultaneous generation of superoxide and nitric oxide

1992 • 702 citations

A Critical Analysis

1995 • 671 citations

Control of cardiac muscle cell function by an endogenous nitric oxide signaling system.

1993 • 656 citations

Intracellular cyclic GMP receptor proteins

1993 • 655 citations

The 1991 Ulf von Euler Lecture:The <scp>l</scp>‐arginine: nitric oxide pathway

1992 • 654 citations

Endothelium-dependent relaxation in rat aorta may be mediated through cyclic GMP-dependent protein phosphorylation

1983 • 623 citations

Induction and potential biological relevance of a Ca²⁺‐independent nitric oxide synthase in the myocardium

1992 • 623 citations

Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme.

1992 • 616 citations

A novel citrulline-forming enzyme implicated in the formation of nitric oxide by vascular endothelial cells

1989 • 612 citations

DETECTION OF COXSACKIE-B-VIRUS-SPECIFIC RNA SEQUENCES IN MYOCARDIAL BIOPSY SAMPLES FROM PATIENTS WITH MYOCARDITIS AND DILATED CARDIOMYOPATHY

1986 • 605 citations

Dexamethasone prevents the induction by endotoxin of a nitric oxide synthase and the associated effects on vascular tone: An insight into endotoxin shock

1990 • 596 citations

Protective and pathological roles of nitric oxide in endotoxin shock

1992 • 594 citations

Differentiation of murine macrophages to express nonspecific cytotoxicity for tumor cells results in L-arginine-dependent inhibition of mitochondrial iron-sulfur enzymes in the macrophage effector cells.

1988 • 592 citations

Reversal of endotoxin-mediated shock by NG-methyl-L-arginine, an inhibitor of nitric oxide synthesis

1990 • 562 citations

Inhibition of nitric oxide synthesis reduces the hypotension induced by bacterial lipopolysaccharides in the rat in vivo

1990 • 536 citations

Cardiac myosin induces myocarditis in genetically predisposed mice.

1987 • 507 citations

Calcium‐dependent nitric oxide synthesis in endothelial cytosol is mediated by calmodulin

1990 • 507 citations

Evidence for cytokine-inducible nitric oxide synthesis from L-arginine in patients receiving interleukin-2 therapy.

1992 • 494 citations

Interleukin 1 and tumor necrosis factor inhibit cardiac myocyte beta-adrenergic responsiveness.

1989 • 493 citations

Molecular cloning and expression of a cDNA encoding endothelial cell nitric oxide synthase.

1992 • 477 citations

Ca2+ current is regulated by cyclic GMP-dependent protein kinase in mammalian cardiac myocytes.

1991 • 475 citations

Purification of the inducible murine macrophage nitric oxide synthase. Identification as a flavoprotein.

1991 • 458 citations

Abnormal contractile function due to induction of nitric oxide synthesis in rat cardiac myocytes follows exposure to activated macrophage-conditioned medium.

1993 • 457 citations

Tissue injury caused by deposition of immune complexes is L-arginine dependent.

1991 • 436 citations

Inhibition of nitric oxide synthesis in septic shock: how much is beneficial?

1991 • 409 citations

Hepatocytes produce nitrogen oxides from L-arginine in response to inflammatory products of Kupffer cells.

1989 • 405 citations

Nitric oxide attenuates cardiac myocyte contraction

1993 • 405 citations

Regulation of cardiac ion channels by catecholamines, acetylcholine and second messenger systems

1988 • 403 citations

Nitric oxide synthase activities in human myocardium

1993 • 358 citations

Autoantibodies against beta-adrenoceptors in human idiopathic dilated cardiomyopathy.

1989 • 337 citations

Synthesis of nitrite and nitrate in murine macrophage cell lines.

1987 • 335 citations

An L-arginine-dependent mechanism mediates kupffer cell inhibition of hepatocyte protein synthesis in vitro

1989 • 325 citations

Identification of alpha- and beta-cardiac myosin heavy chain isoforms as major autoantigens in dilated cardiomyopathy.

1992 • 308 citations

Development of myocardial dysfunction in endotoxin shock

1985 • 297 citations

Nitric oxide synthesized from L‐arginine regulates vascular tone in the coronary circulation of the rabbit

1989 • 279 citations

Interferon-gamma and tumor necrosis factor synergize to induce nitric oxide production and inhibit mitochondrial respiration in vascular smooth muscle cells.

1992 • 276 citations

Effects of damaging the endocardial surface on the mechanical performance of isolated cardiac muscle.

1988 • 260 citations

Nitric oxide synthesised from L-arginine mediates endothelium dependent dilatation in human veins in vivo

1989 • 250 citations

Nitric oxide inhibits viral replication in murine myocarditis.

1996 • 249 citations

Purification of nitric oxide synthase from rat macrophages

1991 • 244 citations

Factors released from endocardium of the ferret and pig modulate myocardial contraction.

1991 • 242 citations

Effect of inhibition of nitric oxide synthesis on epicardial coronary artery caliber and coronary blood flow in humans.

1993 • 233 citations

The role of nitric oxide in endothelial cell damage and its inhibition by glucocorticoids

1992 • 233 citations

Cardiotoxicity of Interferon*

1991 • 218 citations

Mechanism of action of acetylcholine on calcium current in single cells from frog ventricle.

1986 • 214 citations

Immunological analysis of auto-antibodies against the adenine nucleotide translocator in dilated cardiomyopathy

1985 • 214 citations

Interleukin 1 or tumor necrosis factor can promote Coxsackie B3-induced myocarditis in resistant B10.A mice.

1992 • 207 citations

Release of endothelium-derived relaxing factor is modulated both by frequency and amplitude of pulsatile flow

1991 • 200 citations

Reaction of nitric oxide with hydrogen peroxide to produce potentially cytotoxic singlet oxygen as a model for nitric oxide‐mediated killing

1993 • 196 citations

EPR detection of heme and nonheme iron-containing protein nitrosylation by nitric oxide during rejection of rat heart allograft.

1992 • 195 citations

Signal transduction by cGMP in heart

1991 • 181 citations

Nitric oxide production in host-versus-graft and graft-versus-host reactions in the rat.

1992 • 179 citations

Potentiation by cyclic GMP of beta‐adrenergic effect on Ca2+ current in guinea‐pig ventricular cells.

1991 • 167 citations

Nitric oxide synthase in cultured endocardial cells of the pig

1991 • 164 citations

The effect of intracellular cyclic nucleotides and calcium on the action potential and acetylcholine response of isolated cardiac cells

1982 • 164 citations

Effect of inhibition of nitric oxide synthesis on epicardial coronary artery caliber and coronary blood flow in humans

1994 • 144 citations

DEFICIENT NATURAL KILLER CELL ACTIVITY IN PATIENTS WITH IDIOPATHIC DILATED CARDIOMYOPATHY

1982 • 140 citations

Protective effect of S-nitroso-N-acetyl-penicillamine in endotoxin-induced acute intestinal damage in the rat

1990 • 133 citations

Neutralization of endogenous tumor necrosis factor ameliorates the severity of myosin-induced myocarditis.

1992 • 131 citations

The crucial role of physiological Ca²⁺ concentrations in the production of endothelial nitric oxide and the control of vascular tone

1990 • 121 citations

Molecular approaches to enteroviral diagnosis in idiopathic cardiomyopathy and myocarditis

1990 • 115 citations

Interleukin-1 modulates myocardial contraction via dexamethasone sensitive production of nitric oxide

1993 • 108 citations

CYTOKINE GENE EXPRESSION IN REJECTING CARDIAC ALLOGRAFTS

1992 • 106 citations

Interleukin-1-induced myocardial depression in an isolated beating heart preparation.

1989 • 102 citations

Effects of 8-Bromo-cyclic GMP on contraction and on inotropic response of ferret cardiac muscle

1991 • 101 citations

Expression of tumor necrosis factor in human acute cardiac rejection. An immunohistochemical and immunoblotting study.

1991 • 88 citations

Cyclic AMP and cyclic GMP may play opposing roles in influencing force of contraction in mammalian myocardium

1976 • 86 citations

The pathology of cardiomyopathies. A critical analysis

1979 • 85 citations

Atrial natriuretic factor regulates the calcium current in frog isolated cardiac cells.

1988 • 81 citations

Myocardial Toxic Effects During Recombinant Interleukin-2 Therapy

1989 • 80 citations

Endothelial cells regulate cardiac contractility.

1992 • 75 citations

Effects of E. coli endotoxemia on ventricular performance

1966 • 72 citations

Cyclic AMP phosphodiesterases and Ca2+ current regulation in cardiac cells

1991 • 63 citations

Effects of interleukin 2 on cardiac function in the isolated rat heart.

1990 • 63 citations

Actions of atrial natriuretic peptide (ANP) on cyclic nucleotide concentrations and phosphatidylinositol turnover in ventricular myocytes

1987 • 58 citations

Porcine ventricular endocardial cells in culture express the inducible form of nitric oxide synthase

1993 • 57 citations

Role of phosphodiesterase in regulation of calcium current in isolated cardiac myocytes.

1988 • 55 citations

Modulation of myocardial contraction by endocardial and coronary vascular endothelium

1993 • 50 citations

Regulation of calcium current by low-Km cyclic AMP phosphodiesterases in cardiac cells.

1990 • 49 citations

Injection of guanosine 5'-cyclic monophosphate into heart cells blocks calcium slow channels

1985 • 47 citations

Ca(++)-dependent constitutive nitric oxide synthase is not involved in the cyclic GMP-increasing effects of carbachol in ventricular cardiomyocytes.

1993 • 43 citations

Negative inotropic effect of cyclic GMP in cardiac fiber fragments

1976 • 39 citations

Immunomodulating therapy in viral myocarditis: Effects of tumour necrosis factor, interleukin 2 and anti-interleukin-2 receptor antibody in an animal model

1991 • 39 citations

Endothelium, endocardium, and cardiac contraction

1992 • 38 citations

USE OF MONOCLONAL ANTIBODIES TO QUANTITATE T LYMPHOCYTE SUBPOPULATIONS IN HUMAN CARDIAC ALLOGRAFTS

1984 • 36 citations

Inotropic responses of the frog ventricle to dibutyryl cyclic AMP and 8-bromo cyclic GMP and related changes in endogenous cyclic nucleotide levels

1981 • 34 citations

Cyclic-GMP-regulated enzymes and their possible physiological functions.

1984 • 33 citations

Endothelium-derived relaxing factor inhibits platelet adhesion to cultured porcine endocardial endothelium

1992 • 29 citations

Effects of derivatives of cyclic AMP and cyclic GMP on contraction force of cat papillary muscles

1976 • 28 citations

Immune cytokines and cardiac disease

1992 • 24 citations

Viruses and myocardium: notes of a virologist

1987 • 24 citations

A factor released from coronary vascular endothelium inhibits myocardial contractile performance

1993 • 23 citations

Atrial natriuretic peptide reduces the basal level of cytosolic free Ca2+ in guinea pig cardiac myocytes

1990 • 23 citations

Yohimbine increases submaxillary kallikrein release into the saliva in dogs: evidence for α₂‐adrenoceptor‐mediated inhibition of cholinergic pathways

1991 • 19 citations

Management of Patients After Cardiac Transplantation

1992 • 16 citations

Induction of cytokine release from human monocytes by coxsackievirus infection

1991 • 14 citations

Immunologic aspects of rejection

1990 • 14 citations

Does endocardium modulate myocardial contractile performance?

1990 • 12 citations

The association of enteroviruses with chronic heart disease

1992 • 10 citations

Combination therapy of cyclosporine with steroid inhibits ?-interferon and interleukin-1 gene expression at the level of mRNA synthesisin vivo

1989 • 10 citations

Pathology of cardiomyopathies.

1988 • 8 citations

Deleted Work

1955 • 0 citations