International Union of Pharmacology. XXXIII. Mammalian gamma -Aminobutyric AcidB Receptors: Structure and Function

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A Molecular and Cellular Theory of Depression

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RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor

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GABAB-receptor subtypes assemble into functional heteromeric complexes

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Heterodimerization is required for the formation of a functional GABAB receptor

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(–)Baclofen decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptor

1980 • 1,091 citations

GABAB receptors function as a heteromeric assembly of the subunits GABABR1 and GABABR2

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3H-baclofen and 3H-GABA bind to bicuculline-insensitive GABAB sites in rat brain

1981 • 1,044 citations

Expression cloning of GABAB receptors uncovers similarity to metabotropic glutamate receptors

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A G Protein Couples Serotonin and GABA _B Receptors to the Same Channels in Hippocampus

1986 • 870 citations

GABAA and GABAB receptor site distribution in the rat central nervous system

1987 • 865 citations

G Protein-Coupled Inwardly Rectifying K+ Channels (GIRKs) Mediate Postsynaptic but Not Presynaptic Transmitter Actions in Hippocampal Neurons

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Intrathecal Baclofen for Severe Spinal Spasticity

1989 • 700 citations

A Trafficking Checkpoint Controls GABAB Receptor Heterodimerization

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Oligomerization of G-protein-coupled transmitter receptors

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A physiological role for GABAB receptors in the central nervous system

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GABA_B Receptor Pharmacology

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Role of Heteromer Formation in GABA _B Receptor Function

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Epilepsy, Hyperalgesia, Impaired Memory, and Loss of Pre- and Postsynaptic GABAB Responses in Mice Lacking GABAB(1)

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Comparison of the actions of adenosine at pre‐ and postsynaptic receptors in the rat hippocampus in vitro.

1992 • 486 citations

Bicuculline-insensitive gaba receptors on peripheral autonomic nerve terminals

1981 • 376 citations

Pre- and postsynaptic GABAB receptors in the hippocampus have different pharmacological properties

1988 • 368 citations

Allosteric interactions between GB1 andGB2 subunits are required for optimalGABAB receptor function

2001 • 363 citations

The Role of GABA _B Receptor Activation in Absence Seizures of Lethargic ( lh / lh ) Mice

1992 • 355 citations

A role for GABAB receptors in excitation and inhibition of thalamocortical cells

1991 • 354 citations

Phaclofen: a peripheral and central baclofen antagonist

1987 • 349 citations

Distribution and kinetics of GABAB binding sites in rat central nervous system: A quantitative autoradiographic study

1990 • 347 citations

GABAB receptors – the first 7TM heterodimers

1999 • 345 citations

Immunohistochemical localization of GABAB receptors in the rat central nervous system

1999 • 344 citations

Direct hyperpolarizing action of baclofen on hippocampal pyramidal cells

1984 • 342 citations

Control of transient lower esophageal sphincter relaxations and reflux by the GABAB agonist baclofen in normal subjects

2000 • 328 citations

GABA and its receptors in the spinal cord

1996 • 304 citations

CGP 35348: a centrally active blocker of GABAB receptors

1990 • 303 citations

GABA_B‐receptor splice variants GB1a and GB1b in rat brain: developmental regulation, cellular distribution and extrasynaptic localization

1999 • 303 citations

C-Terminal Interaction Is Essential for Surface Trafficking But Not for Heteromeric Assembly of GABA_BReceptors

2001 • 299 citations

Characteristics of GABA_B receptor binding sites on rat whole brain synaptic membranes

1997 • 294 citations

Epileptogenesis and Enhanced Prepulse Inhibition in GABAB1-Deficient Mice

2001 • 278 citations

The GABA Receptors

2007 • 271 citations

G-Protein-Coupled Modulation of Presynaptic Calcium Currents and Transmitter Release by a GABA_BReceptor

1998 • 270 citations

Intrathecally administered baclofen for treatment of children with spasticity of cerebral origin

1997 • 228 citations

Multiple GABAB receptors

1993 • 217 citations

The effects of GABAB agonists and gabapentin on mechanical hyperalgesia in models of neuropathic and inflammatory pain in the rat

2001 • 210 citations

Identification of a GABAB Receptor Subunit, gb2, Required for Functional GABAB Receptor Activity

1999 • 204 citations

2-Hydroxy-saclofen: an improved antagonist at central and peripheral GABAB receptors

1988 • 202 citations

gamma-aminobutyric acid B receptors are negatively coupled to adenylate cyclase in brain, and in the cerebellum these receptors may be associated with granule cells.

1984 • 202 citations

Ability of Baclofen in Reducing Alcohol Intake and Withdrawal Severity: I—Preclinical Evidence

2000 • 202 citations

Phosphinic Acid Analogs of GABA. 2. Selective, Orally Active GABAB Antagonists

1995 • 201 citations

Intracellular Retention of Recombinant GABABReceptors

1998 • 200 citations

Differential expression of ?-aminobutyric acid type B receptor-1a and -1b mRNA variants in GABA and non-GABAergic neurons of the rat brain

2000 • 198 citations

Upregulation of gamma-aminobutyric acid (GABA) B binding sites in rat frontal cortex: a common action of repeated administration of different classes of antidepressants and electroshock.

1985 • 197 citations

Phosphinic Acid Analogs of GABA. 1. New Potent and Selective GABAB Agonists

1995 • 196 citations

γ-Hydroxybutyrate is a weak agonist at recombinant GABAB receptors

1999 • 195 citations

Stiff‐man syndrome treated with intrathecal baclofen

1993 • 193 citations

Ability of Baclofen in Reducing Alcohol Craving and Intake: II—Preliminary Clinical Evidence

2000 • 193 citations

Intrathecal baclofen and muscimol, but not midazolam, are antinociceptive using the rat-formalin model.

1995 • 178 citations

The GABA _B receptor interacts directly with the related transcription factors CREB2 and ATFx

2000 • 175 citations

Intrathecal baclofen administration for control of severe spinal spasticity: Functional improvement and long-term follow-up

1996 • 174 citations

Intrathecal baclofen for long-term treatment of spasticity: a multi-centre study.

1989 • 173 citations

Spatial distribution of GABABR1 receptor mRNA and binding sites in the rat brain

1999 • 173 citations

Baclofen inhibits heroin self-administration behavior and mesolimbic dopamine release.

1999 • 172 citations

Spatial distribution of GABA(B)R1 receptor mRNA and binding sites in the rat brain.

1999 • 171 citations

Human γ-aminobutyric acid type B receptors are differentially expressed and regulate inwardly rectifying K ⁺ channels

1998 • 169 citations

Evidence for GABAB-mediated mechanisms in experimental generalized absence seizures

1992 • 168 citations

gamma-aminobutyric acid(B) receptors: first of the functional metabotropic heterodimers.

2000 • 167 citations

The C-Terminal Domains of the GABA_BReceptor Subunits Mediate Intracellular Trafficking But Are Not Required for Receptor Signaling

2001 • 159 citations

GABAB receptor‐mediated presynaptic inhibition in guinea‐pig hippocampus is caused by reduction of presynaptic Ca2+ influx.

1995 • 157 citations

Activation of the GABAB receptor inhibits transient lower esophageal sphincter relaxations in dogs

1999 • 156 citations

Effects of baclofen on maintenance and reinstatement of intravenous cocaine self-administration in rats

1999 • 155 citations

Response of nicotine self-administration in the rat to manipulations of mu-opioid and γ-aminobutyric acid receptors in the ventral tegmental area

2000 • 154 citations

The expression of GABAB1 and GABAB2 receptor subunits in the cNS differs from that in peripheral tissues

2000 • 154 citations

A comparison of the antinociceptive responses to the GABA-receptor agonists THIP and baclofen

1985 • 151 citations

Pharmacological studies on a rat model of trigeminal neuropathic pain: baclofen, but not carbamazepine, morphine or tricyclic antidepressants, attenuates the allodynia-like behaviour

1999 • 151 citations

Inhibition of GABA_B Receptor Binding by Guanyl Nucleotides

1984 • 150 citations

Baclofen suppression of cocaine self-administration: demonstration using a discrete trials procedure

1997 • 150 citations

Effect of baclofen on cocaine self-administration in rats reinforced under fixed-ratio 1 and progressive-ratio schedules

2000 • 149 citations

γ-Aminobutyric Acid Type B Receptors with Specific Heterodimer Composition and Postsynaptic Actions in Hippocampal Neurons Are Targets of Anticonvulsant Gabapentin Action

2001 • 144 citations

Effect of spinal cord stimulation on tactile hypersensitivity in mononeuropathic rats is potentiated by simultaneous GABAB and adenosine receptor activation

1998 • 144 citations

Opposite effects of GABAB receptor antagonists on absences and convulsive seizures

1997 • 143 citations

Intrathecal baclofen infusion and subsequent orthopedic surgery in patients with spastic cerebral palsy

1998 • 143 citations

GABA_B receptor protein and mRNA distribution in rat spinal cord and dorsal root ganglia

2000 • 142 citations

γ-Aminobutyric Acid Type B Receptor Splice Variant Proteins GBR1a and GBR1b Are Both Associated with GBR2 in Situ and Display Differential Regional and Subcellular Distribution

1999 • 141 citations

GABAB receptor antagonists: potential new anti-absence drugs

1992 • 140 citations

The GABAB agonist baclofen modifies cocaine self-administration in rats.

1998 • 139 citations

Post-training systemic and intra-amygdala administration of the GABA-B agonist baclofen impairs retention

1989 • 135 citations

Analgesia produced by microinjection of baclofen and morphine at brain stem sites

1979 • 134 citations

Continuous intrathecal baclofen infusion in severe spasticity after traumatic or hypoxic brain injury

1997 • 134 citations

Cloning and Tissue Distribution of Novel Splice Variants of the Rat GABABReceptor

1998 • 130 citations

Calcium channel involvement in GABAB receptor-mediated inhibition of GABA release in area CA1 of the rat hippocampus

1995 • 129 citations

Evidence for a G Protein‐Coupled γ‐Hydroxybutyric Acid Receptor

2000 • 129 citations

Effects of intrathecal baclofen on chronic spinal cord injury pain

1996 • 128 citations

Continuous Intrathecal Baclofen Infusion for Symptomatic Generalized Dystonia

1996 • 128 citations

Association of GABAB Receptors and Members of the 14-3-3 Family of Signaling Proteins

2001 • 127 citations

The Metabotropic GABAB Receptor Directly Interacts with the Activating Transcription Factor 4

2000 • 125 citations

Pharmacotherapy of Spasticity: Oral Medications and Intrathecal Baclofen

2001 • 124 citations

Baclofen as an adjuvant analgesic

1994 • 123 citations

Gamma-hydroxybutyric acid: an endogenous neuromodulator with abuse potential?

1999 • 123 citations

Baclofen inhibits more effectively C-afferent than Aδ-afferent glutamatergic transmission in substantia gelatinosa neurons of adult rat spinal cord slices

2000 • 123 citations

PRESYNAPTIC γ‐AMINOBUTYRIC ACID RECEPTORS IN THE RAT ANOCOCCYGEUS MUSCLE AND THEIR ANTAGONISM BY 5‐AMINOVALERIC ACID

1982 • 122 citations

Gabapentin is not a GABAB receptor agonist

2001 • 122 citations

Molecular Identification of the Human GABABR2: Cell Surface Expression and Coupling to Adenylyl Cyclase in the Absence of GABABR1

1999 • 120 citations

Use of Intrathecal Baclofen in the Treatment of Patients With Dystonia

1996 • 120 citations

CGP 36742: The first orally active GABAB blocker improves the cognitive performance of mice, rats, and rhesus monkeys

1993 • 119 citations

The location of GABA_B receptor binding sites in mammalian spinal cord

1987 • 118 citations

Inhibition of transient LES relaxations and reflux in ferrets by GABA receptor agonists

1999 • 118 citations

GABA-receptors in peripheral tissues

1990 • 117 citations

Activation and modulation of neuronal K+ channels by GABA

1992 • 117 citations

Presynaptic GABA_BAutoreceptor Modulation of P/Q-Type Calcium Channels and GABA Release in Rat Suprachiasmatic Nucleus Neurons

1998 • 116 citations

Chronic antidepressants and GABA “B” receptors: A GABA hypothesis of antidepressant drug action

1984 • 115 citations

Characterization of the relationship between gamma-aminobutyric acid B agonists and transmitter-coupled cyclic nucleotide-generating systems in rat brain.

1985 • 113 citations

Presynaptic and postsynaptic GABAB receptors of neocortical neurons of the rat in vitro: Differences in pharmacology and ionic mechanisms

1997 • 112 citations

ALTERNATIVE APPROACHES TO ANALGESIA: BACLOFEN AS A MODEL COMPOUND

1975 • 108 citations

On the putative contribution of GABAB receptors to the electrical events occuring during spontaneous spike and wave discharges

1999 • 108 citations

Antitussive Effect of the GABA-Agonist Baclofen

1997 • 105 citations

GABAB receptor modulation of adenylate cyclase activity in rat brain slices.

1985 • 105 citations

Heteromeric Assembly of GABA_BR1 and GABA_BR2 Receptor Subunits Inhibits Ca²⁺Current in Sympathetic Neurons

2000 • 104 citations

GABA_BReceptor-Mediated Modulation of Presynaptic Currents and Excitatory Transmission at a Fast Central Synapse

1998 • 103 citations

Presynaptic gamma-hydroxybutyric acid (GHB) and gamma-aminobutyric acidB (GABAB) receptor-mediated release of GABA and glutamate (GLU) in rat thalamic ventrobasal nucleus (VB): a possible mechanism for the generation of absence-like seizures induced by GHB.

1995 • 103 citations

Characterization of γ-Aminobutyric Acid Receptor GABAB(1e), a GABAB(1) Splice Variant Encoding a Truncated Receptor

2000 • 101 citations

Baclofen therapy for chronic hiccup

1995 • 101 citations

The gabaergic hypothesis of depression

1989 • 100 citations

GABA_B receptor isoforms GBR1a and GBR1b, appear to be associated with pre‐ and post‐synaptic elements respectively in rat and human cerebellum

1999 • 99 citations

Gabapentin in the Treatment of Cocaine Dependence

2001 • 98 citations

GABA and glutamate release affected by GABA_B receptor antagonists with similar potency: no evidence for pharmacologically different presynaptic receptors

1994 • 96 citations

Peripheral and central sites of action of GABA‐B agonists to inhibit the cough reflex in the cat and guinea pig

1994 • 95 citations

Increased mesolimbic GABA concentration blocks heroin self-administration in the rat.

2000 • 95 citations

Prospective assessment of continuous intrathecal infusion of baclofen for spasticity caused by acquired brain injury: a preliminary report

1997 • 95 citations

GABA_BReceptor Antagonism: Facilitatory Effects on Memory Parallel Those on LTP Induced by TBS but Not HFS

1999 • 94 citations

GABAB receptors and norepinephrine-stimulated cAMP production in rat brain cortex

1984 • 92 citations

Opioid withdrawal activates MAP kinase in locus coeruleus neurons in morphine‐dependent rats in vivo

1998 • 92 citations

The actions of orally active GABAB receptor antagonists on GABAergic transmission in vivo and in vitro

1993 • 92 citations

Baclofen, a selective GABAB receptor agonist, dose-dependently impairs spatial learning in rats

1996 • 91 citations

Intra-VTA Baclofen Attenuates Cocaine Self-Administration on a Progressive Ratio Schedule of Reinforcement

2000 • 90 citations

Presynaptic inhibition by baclofen of miniature EPSCs and IPSCs in substantia gelatinosa neurons of the adult rat spinal dorsal horn

2000 • 90 citations

The anticonvulsant, antihyperalgesic agent gabapentin is an agonist at brain gamma-aminobutyric acid type B receptors negatively coupled to voltage-dependent calcium channels.

2001 • 90 citations

An in situ hybridization study of the distribution of the GABAB2 protein mRNA in the rat CNS

1999 • 90 citations

Intrathecal baclofen alleviates autonomic dysfunction in severe brain injury

2000 • 90 citations

Gamma aminobutyric acid B receptor-mediated inhibition of adenylate cyclase in cultured cerebellar granule cells: blockade by islet-activating protein.

1986 • 89 citations

Distribution of GABAB receptor mRNAs in the rat brain and peripheral organs

1999 • 88 citations

A single intrathecal injection of GABA permanently reverses neuropathic pain after nerve injury

1999 • 88 citations

Distribution of the GABAB receptor subunit gb2 in rat CNS

2000 • 88 citations

The GABAB agonist CGP 44532 decreases cocaine self-administration in rats: demonstration using a progressive ratio and a discrete trials procedure

1999 • 88 citations

Evidence for pharmacologically distinct GABAB receptors associated with cAMP production in rat brain

1996 • 87 citations

GABAB-Mediated Presynaptic Inhibition of Excitatory Transmission and Synaptic Vesicle Dynamics in Cultured Hippocampal Neurons

1997 • 87 citations

The Effects of Intrathecally Administered Baclofen on Function in Patients With Spasticity

1995 • 87 citations

Localization of GABAB (R1) receptors in the rat hippocampus by immunocytochemistry and high resolution autoradiography, with specific reference to its localization in identified hippocampal interneuron subpopulations

1999 • 86 citations

GABAB receptor antagonists elevate both mRNA and protein levels of the neurotrophins nerve growth factor (NGF) and brain-derived neurotrophic factor (BDNF) but not neurotrophin-3 (NT-3) in brain and spinal cord of rats

2000 • 85 citations

Alternative splicing generates a novel isoform of the rat metabotropic GABA_BR1 receptor

1999 • 85 citations

The GABAB receptor antagonist CGP36742 improves learned helplessness in rats

1999 • 83 citations

The pharmacology of adenylyl cyclase modulation by GABAB receptors in rat brain slices

1996 • 83 citations

Increased sensitivity to the antinociceptive activity of (±)-baclofen in an animal model of chronic neuropathic, but not chronic inflammatory hyperalgesia

1994 • 83 citations

Inhibition of N‐ and P/Q‐type calcium channels by postsynaptic GABA_B receptor activation in rat supraoptic neurones

1998 • 83 citations

A New Approach to Control Central Deafferentation Pain: Spinal Intrathecal Baclofen

1995 • 80 citations

Modulation of non‐adrenergic, non‐cholinergic neural bronchoconstriction in guinea‐pig airways via GABA_B‐receptors

1989 • 78 citations

Hippocampal long-term potentiation and spatial learning in the rat: effects of GABAB receptor blockade

1996 • 78 citations

Comparison of the antinociceptive effect of gamma-aminobutyric acid (GABA) agonists: evidence for a cholinergic involvement.

1982 • 78 citations

The pharmacology of SCH 50911: a novel, orally-active GABA-beta receptor antagonist.

1995 • 75 citations

Central inhibitory dysfunctions: Mechanisms and clinical implications

1997 • 75 citations

[3H](−)Baclofen: an improved ligand for GABAB sites

1985 • 74 citations

Pharmacologically distinct GABA_B receptors that mediate inhibition of GABA and glutamate release in human neocortex

1997 • 72 citations

Functional evidence for multiple gamma-aminobutyric acidB receptor subtypes in the rat cerebral cortex.

1992 • 72 citations

Tiagabine antinociception in rodents depends on GABAB receptor activation: parallel antinociception testing and medial thalamus GABA microdialysis

1999 • 71 citations

High‐threshold Ca2+ currents in rat hippocampal interneurones and their selective inhibition by activation of GABA(B) receptors.

1996 • 71 citations

Long Term Intrathecal Baclofen Therapy in Patients with Intractable Spasticity

1995 • 70 citations

Different Subtypes of GABA_B Receptors Are Present at Pre- and Postsynaptic Sites Within the Rat Dorsolateral Septal Nucleus

1999 • 70 citations

Baclofen disrupts passive avoidance retention in rats

1987 • 69 citations

Antagonism of L-baclofen-induced antinociception by CGP 35348 in the spinal cord of the rat

1993 • 69 citations

Nociceptive regulation of GABAB receptor gene expression in rat spinal cord

1999 • 69 citations

Antitussive effects of GABA_B agonists in the cat and guinea‐pig

1993 • 67 citations

Effects of GABAB receptor antagonists on learning and memory retention in a rat model of absence epilepsy

1997 • 67 citations

gamma-Aminobutyric acid (GABA) autoreceptors in rat cerebral cortex and spinal cord represent pharmacologically distinct subtypes of the GABAB receptor.

1993 • 67 citations

Effect of baclofen on gait in spastic MS patients

2000 • 66 citations

GR127935 acts as a partial agonist at recombinant human 5-HT1Dα and 5-HT1Dβ receptors

1996 • 65 citations

Stimulation of GABAB receptors in thebasal forebrain selectively impairs working memory of rats in the double Y-maze

1994 • 65 citations

The effect of baclofen on the transmission in spinal pathways in spastic multiple sclerosis patients

2000 • 64 citations

GABA, glutamate and substance P‐like immunoreactivity release: effects of novel GABA_B antagonists

1996 • 64 citations

Presynaptic regulation of spinal cord tachykinin signaling via GABA B but not GABA A receptor activation

2001 • 63 citations

Pertussis toxin pretreatment discriminates between pre- and postsynaptic actions of baclofen in rat dorsal raphe nucleus in vitro

1988 • 63 citations

The GABAB receptor antagonist CGP36742 attenuates the baclofen- and scopolamine-induced deficit in Morris water maze task in rats

1997 • 63 citations

Stimulation parameters determine role of GABAB receptors in long-term potentiation

1993 • 63 citations

Modulation of neuronal T-type calcium channel currents by photoactivation of intracellular guanosine 5′-0(3-thio) triphosphate

1990 • 62 citations

Inhibitory effect of amiodarone on Na⁺/Ca²⁺ exchange current in guinea‐pig cardiac myocytes

2000 • 62 citations

Baclofen produces dose-related working memory impairments after intraseptal injection

1994 • 62 citations

Intrathecal Baclofen after Traumatic Brain Injury: Early Treatment Using a New Technique to Prevent Spasticity

2001 • 60 citations

GABA_BReceptor-Mediated Inhibition of Tetrodotoxin-Resistant GABA Release in Rodent Hippocampal CA1 Pyramidal Cells

1997 • 59 citations

Baclofen-Induced Memory Impairment

1985 • 58 citations

GABAergic inhibition of hiccup-like reflex induced by electrical stimulation in medulla of cats

1998 • 58 citations

D-Baclofen Is an Antagonist at Baclofen Receptors Mediating Antinociception in the Spinal Cord

1985 • 57 citations

Neurites, Synapses, and Cadherins Reconciled

1997 • 57 citations

Antinociceptive effects of baclofen and muscimol upon intraventricular administration

1980 • 57 citations

Implication of the GABAb receptor in gamma vinyl-GABA's inhibition of cocaine-induced increases in nucleus accumbens dopamine

1999 • 57 citations

Metabotropic GABA receptors facilitate L‐type and inhibit N‐type calcium channels in single salamander retinal neurons

1999 • 56 citations

Microinjection of baclofen in the ventromedial medulla of rats: antinociception at low doses and hyperalgesia at high doses.

1995 • 56 citations

GABAB agonists modulate a transient potassium current in cultured mammalian hippocampal neurons

1990 • 56 citations

Delayed emergence of effects of memory-enhancing drugs: implications for the dynamics of long-term memory.

1994 • 53 citations

The modulatory effects of high affinity GABA B receptor antagonists in an active avoidance learning paradigm in rats

1998 • 52 citations

Strain-dependent effects of post-training GABA receptor agonists and antagonists on memory storage in mice

1993 • 52 citations

The role of GABA-ergic system in human mammary gland pathology and in growth of transplantable murine mammary cancer.

2000 • 52 citations

Pharmacological discrimination between gamma-aminobutyric acid type B receptors regulating cholecystokinin and somatostatin release from rat neocortex synaptosomes.

1994 • 51 citations

Human GABABR genomic structure: evidence for splice variants in GABABR1 but not GABABR2

2001 • 50 citations

Severe tardive dystonia: Treatment with continuous intrathecal baclofen administration

1997 • 50 citations

Possible involvement of K⁺‐conductance in the action of γ‐aminobutyric acid in the guinea‐pig hippocampus

1985 • 49 citations

GABAb receptors are coupled to a barium-insensitive outward rectifying potassium conductance in premotor respiratory neurons

1993 • 49 citations

Modulation of Memory Processing in the Cingulate Cortex of Mice

2000 • 49 citations

The GABAB receptor antagonist CGP 36 742 and the nootropic oxiracetam facilitate the formation of long-term memory

1996 • 49 citations

Coexpression of full-length gamma-aminobutyric acid(B) (GABA(B)) receptors with truncated receptors and metabotropic glutamate receptor 4 supports the GABA(B) heterodimer as the functional receptor.

2000 • 49 citations

GABAB receptors function as heterodimers

1999 • 49 citations

Evidence for GABA-BZ receptor modulation in short-term memory passive avoidance task paradigm in mice.

1990 • 47 citations

Baclofen for Prevention of Migraine

1999 • 47 citations

Immunocytochemical distribution of the GABAB receptor splice variants GABAB R1a and R1b in the rat CNS and dorsal root ganglia

2000 • 46 citations

Intractable hiccups during stroke rehabilitation

1998 • 46 citations

Comparison of antagonist potencies at pre‐ and post‐synaptic GABA_B receptors at inhibitory synapses in the CA1 region of the rat hippocampus

1999 • 46 citations

GABAergic modulation of memory with regard to passive avoidance and conditioned suppression tasks in mice

1988 • 45 citations

Intrathecal Baclofen Therapy for Spinal Origin Spasticity: Spinal Cord Injury, Spinal Cord Disease, and Multiple Sclerosis

1999 • 44 citations

Distribution of GABAB(1a), GABAB(1b) and GABAB2 receptor protein in cerebral cortex and thalamus of adult rats

2001 • 44 citations

Characterization of [³ H]-CGP54626A binding to heterodimeric GABA_B receptors stably expressed in mammalian cells

2000 • 43 citations

Phaclofen: a GABAB blocker reduces long-duration inhibition in the neocortex

1988 • 42 citations

GABAB receptors play a role in the development of tolerance to ethanol in mice

2000 • 42 citations

GABA_B receptor‐mediated effects on vagal pathways to the lower oesophageal sphincter and heart

2000 • 42 citations

GABAB receptor activation inhibits N- and P/Q-type calcium channels in cultured lamprey sensory neurons

1999 • 42 citations

Intrathecal baclofen in tetanus: four cases and a review of reported cases

1997 • 41 citations

Oxotremorine attenuates retrograde amnesia induced by post-training administration of the GABAergic agonists muscimol and baclofen

1991 • 40 citations

Prejunctional GABA-B inhibition of cholinergic, neurally-mediated airway contractions in guinea-pigs

1991 • 40 citations

Involvement of cholinergic systems in the deficit of place learning in Morris water maze task induced by baclofen in rats

1995 • 40 citations

Failure of baclofen to modulate discriminative–stimulus effects of cocaine or methamphetamine in rats

2000 • 40 citations

Mechanism of colchicine impairment on learning and memory, and protective effect of CGP36742 in mice

1997 • 40 citations

In Vivo Evidence that GABA_B Receptors Are Negatively Coupled to Adenylate Cyclase in Rat Striatum

1997 • 40 citations

GABAB receptors as potential targets for drugs able to prevent excessive excitatory amino acid transmission in the spinal cord

1998 • 40 citations

Antinociception produced by systemic R(+)-baclofen hydrochloride is attenuated by CGP 35348 administered to the spinal cord or ventromedial medulla of rats

1996 • 40 citations

Stiff-person syndrome with anti-glutamic acid decarboxylase autoantibodies: Complete remission of symptoms after intrathecal baclofen administration

1995 • 39 citations

Activation of thermogenesis of brown fat in rats by Baclofen

1986 • 38 citations

125I-CGP 64213 Binding to GABAB Receptors in the Brain of Monkeys: Effect of MPTP and Dopaminomimetic Treatments

2000 • 37 citations

Differential expression of pre- and postsynaptic GABAB receptors in rat substantia nigra pars reticulata neurones

1998 • 37 citations

CGP 36 742, an orally active GABAB receptor antagonist, facilitates memory in a social recognition test in rats

1996 • 36 citations

GABA_B receptor‐mediated stimulation of adenylyl cyclase activity in membranes of rat olfactory bulb

1999 • 36 citations

Regulation of neurokinin-1 receptor expression by GABAB receptor agonists

1998 • 35 citations

Synthesis of the Nanomolar Photoaffinity GABAB Receptor Ligand CGP 71872 Reveals Diversity in the Tissue Distribution of GABAB Receptor Forms

1999 • 34 citations

mGluR7-like receptor and GABAB receptor activation enhance neurotoxic effects of N-methyl-d-aspartate in cultured mouse striatal GABAergic neurones

1999 • 34 citations

(-)-baclofen and gamma-aminobutyric acid inhibit calcium currents in isolated retinal ganglion cells.

1991 • 34 citations

Baclofen is cytoprotective to cerebral ischemia in gerbils

1995 • 34 citations

Sustained l-type calcium currents in dissociated deep dorsal horn neurons of the rat: characteristics and modulation

2001 • 34 citations

Baclofen infused in rat hippocampal formation impairs spatial learning

1998 • 33 citations

Chemistry of GABAB Modulators

2007 • 32 citations

Lasting reduction of severe spasticity after ending chronic treatment with intrathecal baclofen.

1996 • 31 citations

Cloning and tissue distribution of a novel isoform of the rat GABABR1 receptor subunit

2001 • 31 citations

γ-Aminobutyric acid type B receptors are expressed and functional in mammalian cardiomyocytes

2000 • 31 citations

Different GABA_B‐Mediated Effects on Protein Kinase C Activity and Immunoreactivity in Neonatal and Adult Rat Hippocampal Slices

1995 • 31 citations

GABAergic presynaptic inhibition of rat neostriatal afferents is mediated by Q-type Ca2+ channels

2000 • 30 citations

Potentiation of NMDA receptor function through somatostatin release: a possible mechanism for the cognition-enhancing activity of GABAB receptor antagonists

2001 • 30 citations

Potential interactions between GABAb and cholinergic systems: baclofen augments scopolamine-induced performance deficits in the eight-arm radial maze

1988 • 29 citations

HYPOTHALAMIC AND MEDULLARY GABA_A AND GABA_b‐ERGIC SYSTEMS DIFFERENTLY REGULATE SYMPATHETIC AND CARDIOVASCULAR SYSTEMS

1995 • 28 citations

Reversal of scopolamine-induced amnesia by the GABAB receptor antagonist CGP 35348 in the mouse

1993 • 28 citations

Cloning and characterization of a novel variant of rat GABABR1 with a truncated C-terminus

2001 • 28 citations

The human GABA_B1b and GABA_B2 heterodimeric recombinant receptor shows low sensitivity to phaclofen and saclofen

2000 • 28 citations

GABA_B presynaptically modulates suprachiasmatic input to hypothalamic paraventricular magnocellular neurons

2000 • 27 citations

Role of cholinergic and GABAergic neuronal systems in cycloheximide-induced amnesia in mice

1988 • 27 citations

Vagal neurotransmission to the ferret lower oesophageal sphincter: inhibition via GABA_B receptors

2000 • 27 citations

Identification of Gα subtype(s) involved in γ-aminobutyric acidB receptor-mediated high-affinity guanosine triphosphatase activity in rat cerebral cortical membranes

2001 • 27 citations

Selective block of rat and human neocortex GABAB receptors regulating somatostatin release by a GABAB antagonist endowed with cognition enhancing activity

1999 • 26 citations

Intrathecal baclofen for severe torsion dystonia in a child

1996 • 26 citations

Functional coupling of GABA B receptors with G proteins that are sensitive to N-ethylmaleimide treatment, suramin, and benzalkonium chloride in rat cerebral cortical membranes

2000 • 24 citations

Effects of repeated administration of baclofen on transient lower esophageal sphincter relaxation in the dog

2000 • 24 citations

Constitutive expression of functional GABA_B receptors in mIL‐tsA58 cells requires both GABA_B(1) and GABA_B(2) genes

2001 • 23 citations

Regulation of intracellular [Ca2+] and GABA release by presynaptic GABAB receptors in rat cerebrocortical synaptosomes

1995 • 23 citations

Biological activity of 3-aminopropyl (methyl) phosphinic acid, a potent and selective GABAB agonist with CNS activity

1993 • 21 citations

Effects of Post‐Training Administration of (−)‐Baclofen and Chlordiazepoxide on Memory Retention in ICRC Swiss Mice: Interactions with GABA_A and GABA_B Receptor Antagonists

1993 • 21 citations

Characterization of the GABA autoreceptor in human neocortex as a pharmacological subtype of the GABAB receptor

1994 • 21 citations

The effect of baclofen on the urinary bladder contraction accompanying micturition in anesthetized rats.

1988 • 20 citations

Ligands for expression cloning and isolation of GABAB receptors

2003 • 20 citations

The GABA-B antagonist CGP 36742 prevent PTZ-kindling-provoked amnesia in rats

2000 • 20 citations

cAMP modulates an S-type K+ channel coupled to GABAB receptors in mammalian respiratory neurons

1997 • 20 citations

An isobolographic analysis of drug interaction between intrathecal clonidine and baclofen in the formalin test in rats

1998 • 20 citations

(+/-)Baclofen sensitive scopolamine-induced short-term memory deficits in mice.

1993 • 20 citations

Comparative activities of the enantiomeric GABAB receptor agonists CGP 44532 and 44533 in central and peripheral tissues

2001 • 19 citations

Layer‐specific immunocytochemical localization of GABA_BR1a and GABA_BR1b receptors in the rat piriform cortex

2000 • 19 citations

Distribution and properties of GABAB antagonist [3H]CGP 62349 binding in the rhesus monkey thalamus and basal ganglia and the influence of lesions in the reticular thalamic nucleus

1999 • 18 citations

Ligands for the isolation of GABAB receptors W. Froestl would like to dedicate this work to the first GABAB chemist, Cr Heinrich Keberle, on the occasion of his 77th birthday.

1999 • 18 citations

Phosphinic acid analogues of γ‐aminobutyric acid (GABA). Synthesis of a new radioligand

1995 • 17 citations

Morpholin-2-yl-phosphinic acids are potent GABAB receptor antagonists in rat brain

1998 • 16 citations

A novel type of GABA receptor in rat spinal cord?

1989 • 15 citations

Effect of long term baclofen treatment on recognition memory and novelty detection

1996 • 15 citations

Effect of pertussis toxin on baclofen- and diphenhydramine-induced amnesia

1998 • 13 citations

GABAergic modulation of yawning behavior

1989 • 13 citations

Synthesis and in vivo evaluation of [11C]CGP62349, a new GABAB receptor antagonist

2000 • 13 citations

Human brain somatostatin release from isolated cortical nerve endings and its modulation through GABA_B receptors

1996 • 13 citations

GABAB Receptor Signaling Pathways

2001 • 12 citations

Characterisation and partial purification of the GABAB receptor from the rat cerebellum using the novel antagonist [ ]CGP 62349

1999 • 12 citations

Human brain cholecystokinin: release of cholecystokinin-like immunoreactivity (CCK-LI) from isolated cortical nerve endings and its modulation through GABA(B) receptors.

1996 • 11 citations

N-Ethylmaleimide selectively blocks presynaptic GABA-B autoreceptor but not heteroreceptor-mediated inhibition in adult rat striatal slices

1999 • 11 citations

Differential effects of phosphonic analogues of GABA on GABAB autoreceptors in rat neocortical slices

1998 • 11 citations

Pertussis toxin decreases absence seizures and GABAB receptor binding in thalamus of a genetically prone rat (GAERS)

1999 • 11 citations

GABAB(1) splice variant mRNAs are differentially affected by electroshock induced seizure in rats

2000 • 10 citations

Gabaergic and cholinergic mediation in the antinociceptive action of homotaurine

1992 • 10 citations

HICCUPS ASSOCIATED WITH LATERAL MEDULLARY SYNDROME

1997 • 10 citations

Intrathecal baclofen increases corticospinal output to hand muscles in multiple sclerosis

1999 • 9 citations

Kontinuierliche intrathekale Verabreichung von Baclofen bei generalisiertem Tetanus

2000 • 8 citations

[Continuous intrathecal injection of baclofen in generalized tetanus. A therapeutic alternative].

1997 • 7 citations

HICCUPS ASSOCIATED WITH LATERAL MEDULLARY SYNDROME

1995 • 6 citations

Developmental regulation of GABAB receptor function in rat spinal cord

2001 • 6 citations

Baclofen Inhibits Postsynaptic Voltage-dependent Calcium Currents of Supraoptic Nucleus Neurons Isolated from Young Rats

1999 • 5 citations

Conditioned suppression: Dissociation of learning in baclofen treated rats

1976 • 5 citations

Quinolinic acid and GABA-B receptor ligand: effect on pyramidal neurons of the CA1 sector of rat's dorsal hippocampus following peripheral administration.

1999 • 3 citations