Ligands for expression cloning and isolation of GABAB receptors

Sequence and functional expression of the GABAA receptor shows a ligand-gated receptor super-family

1987 • 1,621 citations

GABAB-receptor subtypes assemble into functional heteromeric complexes

1998 • 1,163 citations

Heterodimerization is required for the formation of a functional GABAB receptor

1998 • 1,156 citations

(–)Baclofen decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptor

1980 • 1,091 citations

GABAB receptors function as a heteromeric assembly of the subunits GABABR1 and GABABR2

1998 • 1,054 citations

3H-baclofen and 3H-GABA bind to bicuculline-insensitive GABAB sites in rat brain

1981 • 1,044 citations

Expression cloning of GABAB receptors uncovers similarity to metabotropic glutamate receptors

1997 • 1,020 citations

γ-AMINOBUTYRIC ACID IN BRAIN: ITS FORMATION FROM GLUTAMIC ACID

1950 • 679 citations

A Trafficking Checkpoint Controls GABAB Receptor Heterodimerization

2000 • 666 citations

GABAB autoreceptors regulate the induction of LTP

1991 • 613 citations

Role of Heteromer Formation in GABA _B Receptor Function

1999 • 545 citations

GABA, Bicuculline and Central Inhibition

1970 • 545 citations

Epilepsy, Hyperalgesia, Impaired Memory, and Loss of Pre- and Postsynaptic GABAB Responses in Mice Lacking GABAB(1)

2001 • 531 citations

Allosteric interactions between GB1 andGB2 subunits are required for optimalGABAB receptor function

2001 • 363 citations

FREE γ-AMINOBUTYRIC ACID IN BRAIN

1950 • 362 citations

Phaclofen: a peripheral and central baclofen antagonist

1987 • 349 citations

1-Aminoalkylphosphonous acids. Part 1. Isosteres of the protein amino acids

1984 • 337 citations

C-Terminal Interaction Is Essential for Surface Trafficking But Not for Heteromeric Assembly of GABA_BReceptors

2001 • 299 citations

Epileptogenesis and Enhanced Prepulse Inhibition in GABAB1-Deficient Mice

2001 • 278 citations

The GABA Receptors

2007 • 271 citations

Multiple GABAB receptors

1993 • 217 citations

GABA_B2 Is Essential for G-Protein Coupling of the GABA_B Receptor Heterodimer

2001 • 211 citations

Mutagenesis and Modeling of the GABAB Receptor Extracellular Domain Support a Venus Flytrap Mechanism for Ligand Binding

1999 • 209 citations

Phosphinic Acid Analogs of GABA. 2. Selective, Orally Active GABAB Antagonists

1995 • 201 citations

Phosphinic Acid Analogs of GABA. 1. New Potent and Selective GABAB Agonists

1995 • 196 citations

A Single Subunit (GB2) Is Required for G-protein Activation by the Heterodimeric GABAB Receptor

2002 • 194 citations

Function of GB1 and GB2 subunits in G protein coupling of GABA _B receptors

2001 • 175 citations

The C-Terminal Domains of the GABA_BReceptor Subunits Mediate Intracellular Trafficking But Are Not Required for Receptor Signaling

2001 • 159 citations

The expression of GABAB1 and GABAB2 receptor subunits in the cNS differs from that in peripheral tissues

2000 • 154 citations

Is γ-Aminobutyric Acid an Inhibitory Transmitter?

1966 • 130 citations

Cloning and Tissue Distribution of Novel Splice Variants of the Rat GABABReceptor

1998 • 130 citations

Mapping the Agonist-binding Site of GABAB Type 1 Subunit Sheds Light on the Activation Process of GABABReceptors

2000 • 130 citations

Ca²⁺ Requirement for High-Affinity γ-Aminobutyric Acid (GABA) Binding at GABA_B Receptors: Involvement of Serine 269 of the GABA_BR1 Subunit

2000 • 127 citations

The N-Terminal Domain of γ-Aminobutyric Acid_BReceptors Is Sufficient to Specify Agonist and Antagonist Binding

1999 • 107 citations

Characterization of γ-Aminobutyric Acid Receptor GABAB(1e), a GABAB(1) Splice Variant Encoding a Truncated Receptor

2000 • 101 citations

The Effects of Intrathecally Administered Baclofen on Function in Patients With Spasticity

1995 • 87 citations

Alternative splicing generates a novel isoform of the rat metabotropic GABA_BR1 receptor

1999 • 85 citations

Diethoxymethylphosphonites and phosphinates. Intermediates for thesynthesis of α,β- and X aminoalkylphosphonous acids

1989 • 73 citations

Neurites, Synapses, and Cadherins Reconciled

1997 • 57 citations

QSAR and Molecular Modeling Studies of Baclofen Analogues as GABA_B Agonists. Insights into the Role of the Aromatic Moiety in GABA_B Binding and Activation

2001 • 55 citations

Human GABABR genomic structure: evidence for splice variants in GABABR1 but not GABABR2

2001 • 50 citations

Comparison of antagonist potencies at pre‐ and post‐synaptic GABA_B receptors at inhibitory synapses in the CA1 region of the rat hippocampus

1999 • 46 citations

Immunoaffinity purification and characterization of gamma-aminobutyric acid (GABA)B receptor from bovine cerebral cortex.

1993 • 38 citations

Synthesis of the Nanomolar Photoaffinity GABAB Receptor Ligand CGP 71872 Reveals Diversity in the Tissue Distribution of GABAB Receptor Forms

1999 • 34 citations

Chemistry of GABAB Modulators

2007 • 32 citations

Cloning and tissue distribution of a novel isoform of the rat GABABR1 receptor subunit

2001 • 31 citations

Cloning and characterization of a novel variant of rat GABABR1 with a truncated C-terminus

2001 • 28 citations

GABAB receptors expressed in Xenopus oocytes by guinea pig cerebral mRNA are functionally coupled with Ca2+-dependent Cl− channels and with K+ channels, through GTP-binding proteins

1990 • 28 citations

Selective block of rat and human neocortex GABAB receptors regulating somatostatin release by a GABAB antagonist endowed with cognition enhancing activity

1999 • 26 citations

[17] 2-Iminobiotin-containing reagent and affinity columns

1990 • 25 citations

Expression of the GABA_B receptor in Xenopus oocytes and inhibition of the response by activation of protein kinase C

1991 • 22 citations

Biological activity of 3-aminopropyl (methyl) phosphinic acid, a potent and selective GABAB agonist with CNS activity

1993 • 21 citations

Distribution and properties of GABAB antagonist [3H]CGP 62349 binding in the rhesus monkey thalamus and basal ganglia and the influence of lesions in the reticular thalamic nucleus

1999 • 18 citations

Ligands for the isolation of GABAB receptors W. Froestl would like to dedicate this work to the first GABAB chemist, Cr Heinrich Keberle, on the occasion of his 77th birthday.

1999 • 18 citations

Phosphinic acid analogues of γ‐aminobutyric acid (GABA). Synthesis of a new radioligand

1995 • 17 citations

Sensitivity of Xenopus oocytes to changes in extracellular pH: possible relevance to proposed expression of atypical mammalian GABAB receptors

1992 • 17 citations

Synthesis and in vivo evaluation of [11C]CGP62349, a new GABAB receptor antagonist

2000 • 13 citations

Solubilization and characterization of GABA_Breceptor binding sites from porcine brain synaptic membranes

1993 • 12 citations