Potentiation of NMDA receptor function through somatostatin release: a possible mechanism for the cognition-enhancing activity of GABAB receptor antagonists

A synaptic model of memory: long-term potentiation in the hippocampus

1993 • 11,303 citations

Psychopharmacology: The Fourth Generation of Progress

1995 • 2,920 citations

The Essential Role of Hippocampal CA1 NMDA Receptor–Dependent Synaptic Plasticity in Spatial Memory

1996 • 1,750 citations

Reduced somatostatin-like immunoreactivity in cerebral cortex from cases of Alzheimer disease and Alzheimer senile dementa

1980 • 866 citations

The NMDA receptor antagonist D-2-amino-5-phosphonopentanoate (D-AP5) impairs spatial learning and LTP in vivo at intracerebral concentrations comparable to those that block LTP in vitro

1992 • 545 citations

A simple apparatus for studying the release of neurotransmitters from synaptosomes

1974 • 456 citations

Rapid Identification of Subtype-Selective Agonists of the Somatostatin Receptor Through Combinatorial Chemistry

1998 • 455 citations

Immunochemical studies on cholecystokinin. I. Development of sequence-specific radioimmunoassays for porcine triacontatriapeptide cholecystokinin.

1978 • 350 citations

Facilitation of glutamate receptors enhances memory.

1994 • 331 citations

Enhancement of Memory in Alzheimer Disease With Insulin and Somatostatin, but Not Glucose

1999 • 315 citations

Molecular biology of somatostatin receptors

1993 • 311 citations

The neurobiology of somatostatin.

1994 • 275 citations

Survival of basal ganglia neuropeptide Y-somatostatin neurones in Huntington's disease

1985 • 251 citations

Multiple GABAB receptors

1993 • 217 citations

Molecular pharmacology of somatostatin receptors

1994 • 216 citations

Synaptosomes still viable after 25 years of superfusion.

2000 • 208 citations

Phosphinic Acid Analogs of GABA. 2. Selective, Orally Active GABAB Antagonists

1995 • 201 citations

Depletion of somatostatin-like immunoreactivity in the rat central nervous system by cysteamine

1982 • 162 citations

Cysteamine-induced depletion of central somatostatin-like immunoactivity: effects on behavior, learning, memory and brain neurochemistry

1987 • 124 citations

CGP 36742: The first orally active GABAB blocker improves the cognitive performance of mice, rats, and rhesus monkeys

1993 • 119 citations

Selective depletion of somatostatin in rat brain by cysteamine

1982 • 119 citations

Presynaptic NMDA receptors stimulate noradrenaline release in the cerebral cortex

1990 • 114 citations

Phospholipase C activation and Ca²⁺ mobilization by cloned human somatostatin receptor subtypes 1–5, in transfected COS‐7 cells

1994 • 95 citations

The actions of orally active GABAB receptor antagonists on GABAergic transmission in vivo and in vitro

1993 • 92 citations

Loss of somatostatin-like immunoreactivity in the frontal cortex of Alzheimer patients carrying the apolipoprotein epsilon 4 allele

1998 • 84 citations

Decreased somatostatin immunoreactivity but not neuropeptide Y immunoreactivity in cerebral cortex in senile dementia of Alzheimer type

1986 • 76 citations

Molecular Biology of Somatostatin Receptors

2007 • 75 citations

A presynaptic N‐methyl‐<scp>d</scp>‐aspartate autoreceptor in rat hippocampus modulating amino acid release from a cytoplasmic pool

1998 • 75 citations

N-methyl-D-aspartic acid (NMDA) and non-NMDA receptors regulating hippocampal norepinephrine release. II. Evidence for functional cooperation and for coexistence on the same axon terminal.

1992 • 72 citations

Pharmacologically distinct GABA_B receptors that mediate inhibition of GABA and glutamate release in human neocortex

1997 • 72 citations

Brain somatostatin: Receptor-coupled transducing mechanisms and role in cognitive functions

1991 • 60 citations

Somatostatin potentiates NMDA receptor function via activation of InsP₃ receptors and PKC leading to removal of the Mg²⁺ block without depolarization

2000 • 57 citations

Changes in brain somatostatin in memory-deficient rats: comparison with cholinergic markers

1995 • 56 citations

Pharmacological discrimination between gamma-aminobutyric acid type B receptors regulating cholecystokinin and somatostatin release from rat neocortex synaptosomes.

1994 • 51 citations

Selective somatostatin sst2 receptor blockade with the novel cyclic octapeptide, CYN-154806

2000 • 49 citations

Characterisation of human recombinant somatostatin receptors. 4. Modulation of phospholipase C activity

1999 • 46 citations

Characterisation of human recombinant somatostatin receptors. 3. Modulation of adenylate cyclase activity

1999 • 46 citations

Evidence for functional native NMDA receptors activated by glycine or <scp>d</scp>‐serine alone in the absence of glutamatergic coagonist

1998 • 43 citations

Characterization of human recombinant somatostatin sst₅ receptors mediating activation of phosphoinositide metabolism

1997 • 42 citations

Widespread deficits in somatostatin but not neuropeptide Y concentrations in Alzheimer's disease cerebral cortex

1993 • 37 citations

FK960 N-(4-acetyl-1-piperazinyl)-p-fluorobenzamide monohydrate ameliorates the memory deficits in rats through a novel mechanism of action.

1996 • 35 citations

Characterisation of human recombinant somatostatin receptors. 2. Modulation of GTPγS binding

1999 • 34 citations

Selective block of rat and human neocortex GABAB receptors regulating somatostatin release by a GABAB antagonist endowed with cognition enhancing activity

1999 • 26 citations

FK960, a novel potential anti-dementia drug, augments long-term potentiation in mossy fiber-CA3 pathway of guinea-pig hippocampal slices

1998 • 26 citations

In vivo release of somatostatin from rat hippocampus and striatum

1993 • 25 citations

1-BCP, a memory-enhancing agent, selectively potentiates AMPA-induced [3H]norepinephrine release in rat hippocampal slices

1995 • 23 citations

The "kynurenate test", a biochemical assay for putative cognition enhancers.

1997 • 22 citations

Aniracetam, 1-BCP and cyclothiazide differentially modulate the function of NMDA and AMPA receptors mediating enhancement of noradrenaline release in rat hippocampal slices

1999 • 20 citations

Human brain somatostatin release from isolated cortical nerve endings and its modulation through GABA_B receptors

1996 • 13 citations

Human brain cholecystokinin: release of cholecystokinin-like immunoreactivity (CCK-LI) from isolated cortical nerve endings and its modulation through GABA(B) receptors.

1996 • 11 citations

Activity of putative cognition enhancers in kynurenate test performed with human neocortex slices.

1999 • 11 citations