GABAB Receptor Signaling Pathways

GABAB-receptor subtypes assemble into functional heteromeric complexes

1998 • 1,163 citations

Heterodimerization is required for the formation of a functional GABAB receptor

1998 • 1,156 citations

(–)Baclofen decreases neurotransmitter release in the mammalian CNS by an action at a novel GABA receptor

1980 • 1,091 citations

Type-Specific Regulation of Adenylyl Cyclase by G Protein βγ Subunits

1991 • 1,076 citations

GABAB receptors function as a heteromeric assembly of the subunits GABABR1 and GABABR2

1998 • 1,054 citations

Expression cloning of GABAB receptors uncovers similarity to metabotropic glutamate receptors

1997 • 1,020 citations

The GTP-binding protein, Go9 regulates neuronal calcium channels

1987 • 910 citations

A G Protein Couples Serotonin and GABA _B Receptors to the Same Channels in Hippocampus

1986 • 870 citations

G Protein-Coupled Inwardly Rectifying K+ Channels (GIRKs) Mediate Postsynaptic but Not Presynaptic Transmitter Actions in Hippocampal Neurons

1997 • 758 citations

Role of Heteromer Formation in GABA _B Receptor Function

1999 • 545 citations

Pharmacological evidence for two kinds of GABA receptors on rat hippocampal pyramidal cells studied in vitro

1982 • 527 citations

Comparison of the action of baclofen with gamma‐aminobutyric acid on rat hippocampal pyramidal cells in vitro.

1985 • 488 citations

Comparison of the actions of adenosine at pre‐ and postsynaptic receptors in the rat hippocampus in vitro.

1992 • 486 citations

Activation of the cloned muscarinic potassium channel by G protein βγ subunits

1994 • 472 citations

Adenylyl cyclases

1992 • 397 citations

Presynaptic inhibition of miniature excitatory synaptic currents by baclofen and adenosine in the hippocampus

1992 • 369 citations

A role for GABAB receptors in excitation and inhibition of thalamocortical cells

1991 • 354 citations

Regulation of purified type I and type II adenylylcyclases by G protein beta gamma subunits.

1993 • 290 citations

Contributions of calcium-dependent and calcium-independent mechanisms to presynaptic inhibition at a cerebellar synapse

1996 • 288 citations

GABAB Receptor Inhibition of P-type Ca2+ Channels in Central Neurons

1993 • 274 citations

The GABA Receptors

2007 • 271 citations

G-Protein-Coupled Modulation of Presynaptic Calcium Currents and Transmitter Release by a GABA_BReceptor

1998 • 270 citations

Suppression of the Immune Response by a Soluble Complement Receptor of B Lymphocytes

1991 • 242 citations

TWO TYPES OF γ‐AMINOBUTYRIC ACID RECEPTOR ON EMBRYONIC SENSORY NEURONES

1981 • 213 citations

Coexistence of GABA_A and GABA_B receptors on Aδ and C primary afferents

1984 • 211 citations

Comparison of the actions of baclofen at pre‐ and postsynaptic receptors in the rat hippocampus in vitro.

1992 • 203 citations

gamma-aminobutyric acid B receptors are negatively coupled to adenylate cyclase in brain, and in the cerebellum these receptors may be associated with granule cells.

1984 • 202 citations

Central effects of β-(p-chlorophenyl)-γ-aminobutyric acid

1974 • 191 citations

Type-specific stimulation of adenylylcyclase by protein kinase C.

1993 • 187 citations

GABA_BReceptors, Monoamine Receptors, and Postsynaptic Inositol Trisphosphate-Induced Ca²⁺Release Are Involved in the Induction of Long-Term Potentiation at Visual Cortical Inhibitory Synapses

1996 • 158 citations

Inhibition of GABA_B Receptor Binding by Guanyl Nucleotides

1984 • 150 citations

GABAB receptors: drugs meet clones

1998 • 150 citations

γ-Aminobutyric acid-induced depression of calcium currents of chick sensory neurons

1985 • 147 citations

Inhibition of calcium currents by noradrenaline, somatostatin and opioids in guinea‐pig submucosal neurones.

1990 • 146 citations

GABAB receptor antagonists: potential new anti-absence drugs

1992 • 140 citations

Presynaptic GABA_BAutoreceptor Modulation of P/Q-Type Calcium Channels and GABA Release in Rat Suprachiasmatic Nucleus Neurons

1998 • 116 citations

Characterization of the relationship between gamma-aminobutyric acid B agonists and transmitter-coupled cyclic nucleotide-generating systems in rat brain.

1985 • 113 citations

GABAB receptor modulation of Ca2+ currents in rat sensory neurones by the G protein G(0): antisense oligonucleotide studies.

1993 • 110 citations

GABAB receptor modulation of adenylate cyclase activity in rat brain slices.

1985 • 105 citations

An Examination of the Involvement of Phospholipases A₂ and C in the α‐Adrenergic and γ‐Aminobutyric Acid Receptor Modulation of Cyclic AMP Accumulation in Rat Brain Slices

1986 • 97 citations

GABAB receptors and norepinephrine-stimulated cAMP production in rat brain cortex

1984 • 92 citations

Gamma aminobutyric acid B receptor-mediated inhibition of adenylate cyclase in cultured cerebellar granule cells: blockade by islet-activating protein.

1986 • 89 citations

Evidence for pharmacologically distinct GABAB receptors associated with cAMP production in rat brain

1996 • 87 citations

Go transduces GABAB-receptor modulation of N-type calcium channels in cultured dorsal root ganglion neurons

1993 • 85 citations

Heterogeneity of GABAA-receptors: cell-specific expression, pharmacology, and regulation

1995 • 84 citations

Inhibition of N‐ and P/Q‐type calcium channels by postsynaptic GABA_B receptor activation in rat supraoptic neurones

1998 • 83 citations

The pharmacology of adenylyl cyclase modulation by GABAB receptors in rat brain slices

1996 • 83 citations

A comparison of the effect of calcium channel ligands and GABAB agonists and antagonists on transmitter release and somatic calcium channel currents in cultured neurons

1990 • 79 citations

Characteristics of long-duration inhibitory postsynaptic potentials in rat neocortical neuronsin vitro

1987 • 78 citations

Inhibition of calcium influx and calcium current by gamma-aminobutyric acid in single synaptic terminals.

1991 • 72 citations

A region of the muscarinic-gated atrial K+ channel critical for activation by G protein βγ subunits

1994 • 70 citations

An investigation into the mechanisms of inhibition of calcium channel currents in cultured sensory neurones of the rat by guanine nucleotide analogues and (−)− baclofen

1989 • 69 citations

Nociceptive regulation of GABAB receptor gene expression in rat spinal cord

1999 • 69 citations

Evidence for pharmacologically distinct subsets of GABAB receptors

1988 • 63 citations

The involvement of multiple calcium channel sub-types in glutamate release from cerebellar granule cells and its modulation by GABAB receptor activation

1995 • 61 citations

GABA_B‐receptor mediated inhibition of potassium‐evoked release of endogenous 5‐hydroxytryptamine from mouse frontal cortex

1987 • 57 citations

Release of endogenous glutamic and aspartic acids from cerebrocortex synaptosomes and its modulation through activation of a γ-aminobutyric acidB (GABAB) receptor subtype

1993 • 54 citations

The effect of drugs which alter GABA-ergic function on cerebellar guanosine-3′, 5′-monophosphate content

1978 • 52 citations

GABA_B receptors couple to G proteins G_o, G^∗_o and G·_i1 but not to G_i2

1990 • 47 citations

GABA_B Receptor‐Mediated Inhibition of Histamine H₁‐Receptor‐Induced Inositol Phosphate Formation in Slices of Rat Cerebral Cortex

1988 • 45 citations

Possible Therapeutic Application of GABAB Receptor Agonists and Antagonists

1995 • 45 citations

In Vivo Evidence that GABA_B Receptors Are Negatively Coupled to Adenylate Cyclase in Rat Striatum

1997 • 40 citations

Regulation of Mammalian Adenylyl Cyclases by G-Protein and Subunits

1992 • 38 citations

Regulation of neurokinin-1 receptor expression by GABAB receptor agonists

1998 • 35 citations

Potent, stereoselective, and brain region selective modulation of second messengers in the rat brain by (+)LY354740, a novel group II metabotropic glutamate receptor agonist

1998 • 32 citations

GABAB receptor activation inhibits 5-hydroxytryptamine-stimulated inositol phospholipid turnover in mouse cerebral cortex

1988 • 31 citations

Islet‐Activating Protein Inhibits the β‐Adrenergic Receptor Facilitation Elicited by γ‐Aminobutyric Acid_B Receptors

1989 • 27 citations

GABAB receptors negatively regulate transcription in cerebellar granular neurons through cyclic AMP responsive element binding protein-dependent mechanisms

1996 • 27 citations

The molecular biology of GABAA receptors and their structural determinants.

1995 • 27 citations

Pore mutation in a G-protein-gated inwardly rectifying K+ channel subunit causes loss of K+-dependent inhibition in weaver hippocampus.

1998 • 25 citations

Activation of inwardly rectifying K+ channels by GABA-B receptors expressed in Xenopus oocytes

1998 • 25 citations

An antisense oligonucleotide on the mouse Shaker-like potassium channel Kv1.1 gene prevents antinociception induced by morphine and baclofen.

1997 • 25 citations

GABA-receptor stimulation enhances norepinephrine-induced polyphosphoinositide metabolism in rat hippocampal slices

1987 • 24 citations

Pore Mutation in a G-Protein-Gated Inwardly Rectifying K⁺Channel Subunit Causes Loss of K⁺-Dependent Inhibition inweaverHippocampus

1998 • 24 citations

Enhancement by Baclofen of the Gs-Coupled Receptor-Mediated cAMP Production inXenopusOocytes Expressing Rat Brain Cortex Poly (A)+RNA: A Role of G-Protein βγ Subunits

1997 • 16 citations

(-)-Baclofen-induced and constitutively active inwardly rectifying potassium conductances in cultured rat midbrain neurons

1996 • 12 citations

Heteromerization of GABA_B Receptors: A New Principle for G Protein‐Coupled Receptors. Satellite Symposium to the 28^th Annual Meeting of the Society for Neuroscience Los Angeles, CA, November 5–7, 1998

1998 • 4 citations

Cellular and Biochemical Responses to GABAB Receptor Activation

1997 • 4 citations