Evidence for a G Protein‐Coupled γ‐Hydroxybutyric Acid Receptor

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Statistical principles in experimental design.

1962 • 27,228 citations

GABAB-receptor subtypes assemble into functional heteromeric complexes

1998 • 1,163 citations

Heterodimerization is required for the formation of a functional GABAB receptor

1998 • 1,156 citations

GABAB receptors function as a heteromeric assembly of the subunits GABABR1 and GABABR2

1998 • 1,054 citations

Expression cloning of GABAB receptors uncovers similarity to metabotropic glutamate receptors

1997 • 1,020 citations

A G Protein Couples Serotonin and GABA _B Receptors to the Same Channels in Hippocampus

1986 • 870 citations

Role of Heteromer Formation in GABA _B Receptor Function

1999 • 545 citations

THE γ-HYDROXYBUTYRATE SIGNALLING SYSTEM IN BRAIN: ORGANIZATION AND FUNCTIONAL IMPLICATIONS

1997 • 453 citations

In vitro autoradiography of receptor-activated G proteins in rat brain by agonist-stimulated guanylyl 5'-[gamma-[35S]thio]-triphosphate binding.

1995 • 450 citations

Modulation by mu-opioid agonists of guanosine-5'-O-(3-[35S]thio)triphosphate binding to membranes from human neuroblastoma SH-SY5Y cells.

1995 • 441 citations

Increased transmitter release at excitatory synapses produced by direct activation of adenylate cyclase in rat hippocampal slices

1994 • 320 citations

GABA_B‐receptor splice variants GB1a and GB1b in rat brain: developmental regulation, cellular distribution and extrasynaptic localization

1999 • 303 citations

The Pharmacology and Function of Central GabaB Receptors

1994 • 242 citations

High affinity binding site for γ-hydroxybutyric acid in rat brain

1982 • 207 citations

Activation of Cyclic AMP‐Generating Systems in Brain Membranes and Slices by the Diterpene Forskolin: Augmentation of Receptor‐Mediated Responses

1982 • 202 citations

γ-Hydroxybutyrate is a weak agonist at recombinant GABAB receptors

1999 • 195 citations

Benzodiazepine agonist and inverse agonist actions on GABAA receptor-operated chloride channels. II. Chronic effects of ethanol.

1990 • 163 citations

Measurement of guanine nucleotide-binding protein activation by A1 adenosine receptor agonists in bovine brain membranes: stimulation of guanosine-5'-O-(3-[35S]thio)triphosphate binding.

1993 • 154 citations

Gammahydroxybutyrate: An overview of the pros and cons for it being a neurotransmitter and/or a useful therapeutic agent

1994 • 149 citations

A specific gamma-hydroxybutyrate receptor ligand possesses both antagonistic and anticonvulsant properties.

1990 • 146 citations

γ‐Hydroxybutyrate Model of Generalized Absence Seizures: Further Characterization and Comparison with Other Absence Models

1988 • 146 citations

Identification of endogenous gamma-hydroxybutyrate in human and bovine brain and its regional distribution in human, guinea pig and rhesus monkey brain.

1978 • 144 citations

Gamma‐hydroxybutyric acid: an emerging recreational drug

1998 • 140 citations

Binding characteristics of γ-hydroxybutyric acid as a weak but selective GABAB receptor agonist

1997 • 136 citations

Gamma-hydroxybutyric acid binding sites in rat and human brain synaptosomal membranes

1984 • 129 citations

Gamma-hydroxybutyric acid: an endogenous neuromodulator with abuse potential?

1999 • 123 citations

Sites of Action of Gamma-Hydroxybutyrate (GHB)–A Neuroactive Drug with Abuse Potential

1997 • 121 citations

Differential ontogenesis of presynaptic and postsynaptic GABAB inhibition in rat somatosensory cortex

1993 • 116 citations

Characterization of the relationship between gamma-aminobutyric acid B agonists and transmitter-coupled cyclic nucleotide-generating systems in rat brain.

1985 • 113 citations

The γ-hydroxybutyrate model of absence seizures: correlation of regional brain levels of γ-hydroxybutyric acid and γ-butyrolactone with spike wave discharges

1991 • 112 citations

Extracellular Events Induced by γ‐Hydroxybutyrate in Striatum: A Microdialysis Study

1991 • 112 citations

Absence epilepsy: advances in experimental animal models.

1999 • 106 citations

Efficacy of gamma-hydroxybutyrate versus placebo in treating narcolepsy-cataplexy: Double-blind subjective measures

1989 • 105 citations

Presynaptic gamma-hydroxybutyric acid (GHB) and gamma-aminobutyric acidB (GABAB) receptor-mediated release of GABA and glutamate (GLU) in rat thalamic ventrobasal nucleus (VB): a possible mechanism for the generation of absence-like seizures induced by GHB.

1995 • 103 citations

γ-Hydroxybutyrate hyperpolarizes hippocampal neurones by activating GABAB receptors

1992 • 98 citations

Selective distribution pattern of γ-hydroxybutyrate receptors in the rat forebrain and midbrain as revealed by quantitative autoradiography

1992 • 95 citations

Antagonism of presynaptically mediated depressant responses and cyclic AMP-coupled metabotropic glutamate receptors

1994 • 95 citations

Accumulations of Cyclic AMP in Adenine‐Labeled Cell‐free Preparations from Guinea Pig Cerebral Cortex: Role of α‐Adrenergic and H₁‐Histaminergic Receptors

1980 • 93 citations

Review. The role of gamma-hydroxybutyric acid in the treatment of alcoholism: from animal to clinical studies

1999 • 92 citations

KINETICS OF IN VIVO CONVERSION OF γ‐[³H]AMINOBUTYRIC ACID TO γ‐[³H]HYDROXYBUTYRIC ACID BY RAT BRAIN^1,2

1977 • 91 citations

In vivo conversion of γ-aminobutyric acid and 1,4-butanediol to γ-hydroxybutyric acid in rat brain

1989 • 89 citations

PURIFICATION FROM HUMAN BRAIN AND SOME PROPERTIES OF TWO NADPH‐LINKED ALDEHYDE REDUCTASES WHICH REDUCE SUCCINIC SEMIALDEHYDE TO 4‐HYDROXYBUTYRATE

1979 • 88 citations

Evidence for pharmacologically distinct GABAB receptors associated with cAMP production in rat brain

1996 • 87 citations

gamma-Hydroxybutyrate conversion into GABA induces displacement of GABAB binding that is blocked by valproate and ethosuximide.

1997 • 86 citations

Gamma-hydroxybutyrate promotes oscillatory activity of rat and cat thalamocortical neurons by a tonic GABAB receptor-mediated hyperpolarization

1995 • 85 citations

The ontogeny of [ 3 H]γ-hydroxybutyrate and [ 3 H]GABA B binding sites: relation to the development of experimental absence seizures

1994 • 84 citations

The pharmacology of adenylyl cyclase modulation by GABAB receptors in rat brain slices

1996 • 83 citations

Ontogeny of γ-hydroxybutyric acid. I. Regional concentration in developing rat, monkey and human brain

1981 • 77 citations

PREPARATION AND PROPERTIES OF A CELL‐FREE, HORMONALLY RESPONSIVE ADENYLATE CYCLASE FROM GUINEA PIG BRAIN¹

1974 • 75 citations

Pharmacology, distribution, cellular localization, and development of GABAB binding in rodent cerebellum

1993 • 69 citations

Inhibition of firing rate and changes in the firing pattern of nigral dopamine neurons by γ-hydroxybutyric acid (GHBA) are specifically induced by activation of GABAB receptors

1998 • 67 citations

Low doses of γ-hydroxybutyric acid stimulate the firing rate of dopaminergic neurons in unanesthetized rats

1991 • 67 citations

The Presynaptic Calcium Channel Is Part of a Transmembrane Complex Linking a Synaptic Laminin (α4β2γ1) with Non-Erythroid Spectrin

2000 • 66 citations

Gamma hydroxybutyrate distribution and turnover rates in discrete brain regions of the rat

1988 • 66 citations

Isolation and characterization of synaptoneurosomes from single rat hippocampal slices

1997 • 65 citations

Depolarization‐Induced Phosphorylation of the Protein Kinase C Substrate B‐50 (GAP‐43) in Rat Cortical Synaptosomes

1990 • 65 citations

Gamma-hydroxybutyrate is a GABAB receptor agonist that increases a potassium conductance in rat ventral tegmental dopamine neurons.

1998 • 64 citations

Evidence for pharmacologically distinct subsets of GABAB receptors

1988 • 63 citations

Regulation of γ-aminobutyric acid (GABA) release in cerebral cortex in the γ-hydroxybutyric acid (GHB) model of absence seizures in rat

2000 • 60 citations

Regional and Subcellular Localization in Rat Brain of the Enzymes That Can Synthesize γ‐Hydroxybutyric Acid

1981 • 59 citations

Regional Distribution of High‐Affinity γ‐[³H] Hydroxybutyrate Binding Sites as Determined by Quantitative Autoradiography

1987 • 58 citations

Relation of the [3H]γ-hydroxybutyric acid (ghb) binding site to the γ-aminobutyric acidb (gabab) receptor in rat brain

1996 • 55 citations

Depolarization‐Evoked Release of γ‐Hydroxybutyrate from Rat Brain Slices

1983 • 55 citations

gamma-Hydroxybutyrate modulates synthesis and extracellular concentration of gamma-aminobutyric acid in discrete rat brain regions in vivo.

1999 • 54 citations

Effect of γ-hydroxybutyrate on central dopamine release in vivo

1997 • 53 citations

Effect of gamma-hydroxybutyrate and its antagonist NCS-382 on spontaneous cell firing in the prefrontal cortex of the rat

1995 • 49 citations

Gamma hydroxybutyrate is not a GABA agonist

1996 • 48 citations

?-Hydroxybutyrate uptake by rat brain striatal slices

1985 • 47 citations

The GABAB antagonist, CGP 35348, antagonizes the effects of baclofen, ?-butyrolactone and HA 966 on rat striatal dopamine synthesis

1991 • 46 citations

γ‐Hydroxybutyrate Stimulation of the Formation of Cyclic GMP and Inositol Phosphates in Rat Hippocampal Slices

1989 • 45 citations

Chlorpyrifos releases norepinephrine from adult and neonatal rat brain synaptosomes

1999 • 45 citations

γ-Hydroxybutyrate receptor binding in rat brain is inhibited by guanyl nucleotides and pertussis toxin

1995 • 42 citations

Neurochemical and electrophysiological evidence for the existence of a functional γ-hydroxybutyrate system in NCB-20 neurons

1998 • 40 citations

γ-Hydroxybutyrate inhibits excitatory postsynaptic potentials in rat hippocampal slices

1999 • 39 citations

3′–5′ cyclic-guanosine monophosphate increase in rat brain hippocampus after gamma-hydroxybutyrate administration. Prevention by valproate and naloxone

1987 • 37 citations

Postnatal development of GABA_B receptor‐mediated modulation of voltage‐activated Ca²⁺ currents in mouse brain‐stem neurons

1999 • 36 citations

γ‐Hydroxybutyric Acid in Subcellular Fractions of Rat Brain

1987 • 34 citations

Differential Requirements of Sodium for Coupling of Cannabinoid Receptors to Adenylyl Cyclase in Rat Brain Membranes

1994 • 34 citations

Gamma-hydroxybutyric acid decreases thalamic sensory excitatory postsynaptic potentials by an action on presynaptic GABAB receptors

1996 • 33 citations

Presynaptic GABA_B Receptor Modulation of Glutamate Exocytosis from Rat Cerebrocortical Nerve Terminals: Receptor Decoupling by Protein Kinase C

1998 • 32 citations

Postnatal development of muscarinic autoreceptors modulating acetylcholine release in the septohippocampal cholinergic system

1998 • 31 citations

Presynaptic GABAB-and γ-hydroxybutyric acid-mediated mechanisms in generalized absence seizures

1996 • 27 citations

γ-hydroxybutyrate receptor function studied by the modulation of nitric oxide synthase activity in rat frontal cortex punches

1999 • 26 citations

H1- and H2-histamine receptors linked to adenylate cyclase in cell-free preparations of guinea pig cerebral cortex

1978 • 26 citations

Increased γ-hydroxybutyric acid receptors in thalamus of a genetic animal model of petit mal epilepsy

1990 • 26 citations

A simple procedure for assaying cAMP

1994 • 24 citations

Immunocytochemical localization in rat brain of the enzyme that synthesizes γ-hydroxybutyric acid

1982 • 23 citations

γ‐Aminobutyric Acid_A Receptor Pharmacology in Rat Cerebral Cortical Synaptoneurosomes

1992 • 21 citations

Evidence for G protein modulation of experimental-generalized absence seizures in rat

1992 • 20 citations

Stimulation of Postsynaptic and Inhibition of Presynaptic Adenylyl Cyclase Activity by Metabotropic Glutamate: Receptor Activation

1994 • 19 citations

Absence seizures decrease steroid modulation of t-[35S]butylbicyclophosphorothionate binding in thalamic relay nuclei.

1998 • 19 citations

GABAB receptor-mediated inhibition of forskolin-stimulated cyclic AMP accumulation in rat spinal cord

1993 • 19 citations

Pathophysiological implications of the structural organization of the excitatory synapse

1999 • 18 citations

Effect of Guanosine 5′‐O‐(3‐Thiotriphosphate) and Calcium on γ‐Aminobutyric Acid_B Binding as a Function of Postnatal Development

1989 • 13 citations

Measured increase in intracellular Ca2+ during stimulated release of endogenous glutamate from human cerebrocortical synaptosomes

1999 • 8 citations

Membrane Biophysics and Biochemistry

1999 • 4 citations