Posttranslational modification of proteins by isoprenoids in mammalian cells

Regulation of the mevalonate pathway

1990 • 5,282 citations

All ras proteins are polyisoprenylated but only some are palmitoylated

1989 • 1,806 citations

Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.

1980 • 1,607 citations

p21ras is modified by a farnesyl isoprenoid.

1989 • 847 citations

Inhibition of purified p21ras farnesyl:protein transferase by Cys-AAX tetrapeptides

1990 • 815 citations

Competitive inhibition of 3‐hydroxy‐3‐methylglutaryl coenzyme a reductase by ML‐236A and ML‐236B fungal metabolites, having hypocholesterolemic activity

1976 • 788 citations

rac, a novel ras-related family of proteins that are botulinum toxin substrates

1989 • 585 citations

Genetic and Pharmacological Suppression of Oncogenic Mutations in RAS Genes of Yeast and Humans

1989 • 535 citations

Prenyl proteins in eukaryotic cells: a new type of membrane anchor

1990 • 465 citations

Pertussis toxin-catalyzed ADP-ribosylation of transducin. Cysteine 347 is the ADP-ribose acceptor site.

1985 • 457 citations

G proteins control diverse pathways of transmembrane signaling ¹

1989 • 399 citations

The Human Rab Genes Encode a Family of GTP-binding Proteins Related to Yeast YPT1 and SEC4 Products Involved in Secretion

1989 • 387 citations

Posttranslational modification of the Ha-ras oncogene protein: evidence for a third class of protein carboxyl methyltransferases.

1988 • 384 citations

Structure of Saccharomyces cerevisiae mating hormone a-factor. Identification of S-farnesyl cysteine as a structural component.

1988 • 373 citations

A lamin B receptor in the nuclear envelope.

1988 • 370 citations

Relation of cholesterol and mevalonic acid to the cell cycle in smooth muscle and swiss 3T3 cells stimulated to divide by platelet-derived growth factor.

1980 • 353 citations

Human Lamin B Contains a Farnesylated Cysteine Residue

1989 • 324 citations

Essential role for mevalonate synthesis in DNA replication

1979 • 297 citations

Evidence for modification of lamin B by a product of mevalonic acid.

1988 • 254 citations

Evidence for post-translational incorporation of a product of mevalonic acid into Swiss 3T3 cell proteins.

1984 • 236 citations

Brain G protein gamma subunits contain an all-trans-geranylgeranylcysteine methyl ester at their carboxyl termini.

1990 • 230 citations

G protein gamma subunits contain a 20-carbon isoprenoid.

1990 • 229 citations

Isoprenylation is required for the processing of the lamin A precursor.

1990 • 228 citations

The CaaX motif of lamin A functions in conjunction with the nuclear localization signal to target assembly to the nuclear envelope

1989 • 227 citations

Polyisoprenylation of Ras in vitro by a farnesyl-protein transferase.

1990 • 222 citations

Identification of Geranylgeranyl-Modified Proteins in HeLa Cells

1990 • 217 citations

Purification of the major GTP-binding proteins from human placental membranes.

1986 • 190 citations

A novel small molecular weight GTP-binding protein with the same putative effector domain as the ras proteins in bovine brain membranes. Purification, determination of primary structure, and characterization.

1988 • 185 citations

Modification of nuclear lamin proteins by a mevalonic acid derivative occurs in reticulocyte lysates and requires the cysteine residue of the C-terminal CXXM motif.

1989 • 183 citations

Incorporation of a product of mevalonic acid metabolism into proteins of Chinese hamster ovary cell nuclei.

1988 • 181 citations

Prenylated Proteins: the Structure of the Isoprenoid Group

1990 • 166 citations

Identification of a 32K plasma membrane protein that binds to the myristylated amino-terminal sequence of p60v-src

1990 • 162 citations

Relationship between mevalonate and mitogenesis in human fibroblasts stimulated with platelet-derived growth factor.

1984 • 155 citations

Coding sequence of humanrhocDNAs clone 6 and clone 9

1988 • 137 citations

Isoprenylated proteins in cultured cells: Subcellular distribution and changes related to altered morphology and growth arrest induced by mevalonate deprivation

1987 • 136 citations

The conserved carboxy-terminal cysteine of nuclear lamins is essential for lamin association with the nuclear envelope.

1989 • 134 citations

Defective macromolecule biosynthesis and cell-cycle progression in a mammalian cell starved for mevalonate.

1985 • 133 citations

Suppression of murine neuroblastoma growth in vivo by mevinolin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

1985 • 129 citations

Common Modifications of Trimeric G Proteins and ras Protein: Involvement of Polyisoprenylation

1990 • 122 citations

Characterization and expression of the human rhoH12 gene product.

1989 • 108 citations

Post-translational modification of low molecular mass GTP-binding proteins by isoprenoid.

1990 • 103 citations

Isoprenylation of C-terminal cysteine in a G-protein gamma subunit.

1990 • 95 citations

Post-translational isoprenylation of cellular proteins is altered in response to mevalonate availability

1989 • 89 citations

Differentiation of neuroblastoma cells induced by an inhibitor of mevalonate synthesis: Relation of neurite outgrowth and acetylcholinesterase activity to changes in cell proliferation and blocked isoprenoid synthesis

1985 • 87 citations

Coding sequences of humanralAandralBcDNAs

1989 • 79 citations

Inhibition of isoprenoid biosynthesis and the post-translational modification of pro-p21.

1990 • 78 citations

Lamin B methylation and assembly into the nuclear envelope

1989 • 70 citations

A study of the Influence of mevalonic acid and its metabolites on the morphology of swiss 3T3 cells.

1982 • 70 citations

Identification and purification from bovine brain of a guanine-nucleotide-binding protein distinct from Gs, Gi and Go

1987 • 69 citations

Characterization of isoprenoid involved in the post-translational modification of mammalian cell proteins

1989 • 65 citations

Isoprenoid modification of G25K (Gp), a low molecular mass GTP-binding protein distinct from p21ras.

1990 • 61 citations

The identification and characterization of an epidermal growth factor-stimulated phosphorylation of a specific low molecular weight GTP-binding protein in a reconstituted phospholipid vesicle system.

1990 • 60 citations

Characterization of G25K, a GTP-binding protein containing a novel putative nucleotide binding domain

1989 • 59 citations

Testis-specific transcription initiation sites of rat farnesyl pyrophosphate synthetase mRNA.

1990 • 54 citations

Relation of mevalonate synthesis to mitochondrial ubiquinone content and respiratory function in cultured neuroblastoma cells.

1985 • 53 citations

Structure of Tremerogen A–10, a Peptidal Hormone Inducing Conjugation Tube Formation inTremella mesenterica

1979 • 40 citations

Cellular distribution of cholesterogenesis‐linked, phosphoisoprenylated proteins in proliferating cells

1989 • 40 citations

Prenylated proteins from kidney

1986 • 33 citations

Structure confirmation of S-trans-trans-farnesylcysteine in rhodotorucine A by application of sulfonium salt cleavage reaction.

1979 • 24 citations

Prenyltransferase. Product binding and reaction termination.

1979 • 21 citations