p21ras is modified by a farnesyl isoprenoid.

ras GENES

1987 • 3,818 citations

All ras proteins are polyisoprenylated but only some are palmitoylated

1989 • 1,806 citations

Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth.

1980 • 1,195 citations

Comparative biochemical properties of normal and activated human ras p21 protein

1984 • 713 citations

Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 molecules.

1984 • 607 citations

The p21 ras C-terminus is required for transformation and membrane association

1984 • 590 citations

Post-translational processing of p21ras is two-step and involves carboxyl-methylation and carboxy-terminal proteolysis.

1989 • 462 citations

Harvey murine sarcoma virus p21 ras protein: biological and biochemical significance of the cysteine nearest the carboxy terminus.

1984 • 403 citations

Posttranslational modification of the Ha-ras oncogene protein: evidence for a third class of protein carboxyl methyltransferases.

1988 • 384 citations

Structure of Saccharomyces cerevisiae mating hormone a-factor. Identification of S-farnesyl cysteine as a structural component.

1988 • 373 citations

Dynamic fatty acylation of p21N-ras.

1987 • 309 citations

Myristoylated alpha subunits of guanine nucleotide-binding regulatory proteins.

1987 • 276 citations

RAM, a gene of yeast required for a functional modification of RAS proteins and for production of mating pheromone a-factor

1986 • 259 citations

Evidence for modification of lamin B by a product of mevalonic acid.

1988 • 254 citations

Evidence for post-translational incorporation of a product of mevalonic acid into Swiss 3T3 cell proteins.

1984 • 236 citations

Incorporation of a product of mevalonic acid metabolism into proteins of Chinese hamster ovary cell nuclei.

1988 • 181 citations

Activation of the Cellular Proto-Oncogene Product p21Ras by Addition of a Myristylation Signal

1989 • 158 citations

Direct identification of palmitic acid as the lipid attached to p21ras.

1986 • 157 citations

Relationship between mevalonate and mitogenesis in human fibroblasts stimulated with platelet-derived growth factor.

1984 • 155 citations

Structure of rhodotorucine A, a novel lipopeptide, inducing mating tube formation in Rhodosporidiumtoruloides

1978 • 145 citations

Isoprenylated proteins in cultured cells: Subcellular distribution and changes related to altered morphology and growth arrest induced by mevalonate deprivation

1987 • 136 citations

Posttranslational processing of p21 ras proteins involves palmitylation of the C-terminal tetrapeptide containing cysteine-186

1985 • 120 citations

Expression of specific high capacity mevalonate transport in a Chinese hamster cell variant.

1987 • 71 citations

The six amino-terminal amino acids of p60src are sufficient to cause myristylation of p21v-ras.

1988 • 44 citations

Direct Identification of Palmitic Acid as the Lipid Attached to p21^ras

1986 • 42 citations

Posttranslational modification of ras proteins: Detection of a modification prior to fatty acid acylation and cloning of a gene responsible for the modification

1988 • 41 citations

The Six Amino-Terminal Amino Acids of p60^src Are Sufficient To Cause Myristylation of p21^v-ras

1988 • 19 citations

Beyond transcriptional events

1989 • 17 citations

Expression of the Kirsten ras viral and human proteins in Escherichia coli

1987 • 14 citations