Essential role for mevalonate synthesis in DNA replication

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogensis produced by Penicillium citrinum.

1976 • 926 citations

Competitive inhibition of 3‐hydroxy‐3‐methylglutaryl coenzyme a reductase by ML‐236A and ML‐236B fungal metabolites, having hypocholesterolemic activity

1976 • 788 citations

Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase

1978 • 556 citations

Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Activity in Cultured Human Fibroblasts

1974 • 545 citations

Suppression of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Activity and Inhibition of Growth of Human Fibroblasts by 7-Ketocholesterol

1974 • 502 citations

The utilization of sterols by insects

1964 • 442 citations

Inhibitory Effects on Lipid Metabolismn in Cultured Cells of ML‐236B, a Potent Inhibitor of 3‐Hydroxt‐3‐methylglutaryl‐Cornzyme‐A Reductase

1978 • 252 citations

Relationship between sterol synthesis and DNA synthesis in phytohemagglutinin-stimulated mouse lymphocytes.

1975 • 218 citations

Consequences of blocked sterol synthesis in cultured cells. DNA synthesis and membrane composition.

1977 • 216 citations

An evaluation of the double thymidine block for synchronizing mammalian cells at the G1-S border*1

1971 • 181 citations

DELETION OF THE CHOLESTEROL-NEGATIVE FEEDBACK SYSTEM IN LIVER TUMORS.

1964 • 170 citations

Cholesterol as a Bioregulator in the Development and Inhibition of Leukemia

1974 • 136 citations

Further studies on the deletion of the cholesterol feedback system in hepatomas.

1966 • 113 citations

THE EFFECT OF SOME DIETARY ADDITIONS ON THE SYNTHESIS OF CHOLESTEROL FROM ACETATE IN VITRO

1953 • 113 citations

Increase of Cholesterol Level in the Surface Membrane of Lymphoma Cells and Its Inhibitory Effect on Ascites Tumor Development

1974 • 108 citations

Studies of the In Vivo Metabolism of Mevalonic Acid in the Normal Rat

1973 • 78 citations

Regulation of sterol synthesis in developing brains of normal and jimpy mice

1969 • 76 citations

Control of sterol synthesis and of hydroxymethylglutaryl CoA reductase in skin fibroblasts grown from patients with homozygous type II hyperlipoproteinemia

1975 • 75 citations

Loss of Feedback Control of Hydroxymethylglutaryl Coenzyme A Reductase in Hepatomas

1971 • 60 citations

Dexyribonucleic acid polymerases of BHK-21/C13cells. Relationship to the physiological state of the cells, and to synchronous indution of synthesis of deoxyribonuleic acid

1975 • 56 citations

Changes in DNA and RNA synthesis and associated enzyme activities after the stimulation of serum-depleted BHK21/C13 cells by the addition of serum

1974 • 44 citations

Loss of the Cholesterol Feedback System in the Intact Hepatoma-Bearing Rat

1972 • 36 citations

Control of cholesterol synthesis in hepatomas

1972 • 16 citations

Histoenzymological and cytophotometric studies on the variations of some enzymatic activities in different cell cycle phases in cultured cells

1970 • 10 citations

Variation of deoxyribonucleic acid polymerases in the cell cycle.

1977 • 9 citations

A new method for cell culture synchronisation

1974 • 7 citations