Post-translational modification of low molecular mass GTP-binding proteins by isoprenoid.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications.

1979 • 54,907 citations

ras GENES

1987 • 3,818 citations

All ras proteins are polyisoprenylated but only some are palmitoylated

1989 • 1,806 citations

Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.

1980 • 1,607 citations

Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth.

1980 • 1,195 citations

p21ras is modified by a farnesyl isoprenoid.

1989 • 847 citations

Two dimensional gel electrophoresis and computer analysis of proteins synthesized by clonal cell lines.

1979 • 759 citations

cDNA sequencing of nuclear lamins A and C reveals primary and secondary structural homology to intermediate filament proteins.

1986 • 711 citations

The yeast GTP-binding YPT1 protein and a mammalian counterpart are associated with the secretion machinery

1988 • 699 citations

Functional Organization Of The Nuclear Envelope

1988 • 593 citations

The p21 ras C-terminus is required for transformation and membrane association

1984 • 590 citations

Genetic and Pharmacological Suppression of Oncogenic Mutations in RAS Genes of Yeast and Humans

1989 • 535 citations

A novel ras-related gene family

1985 • 487 citations

Post-translational processing of p21ras is two-step and involves carboxyl-methylation and carboxy-terminal proteolysis.

1989 • 462 citations

Four additional members of the ras gene superfamily isolated by an oligonucleotide strategy: molecular cloning of YPT-related cDNAs from a rat brain library.

1987 • 403 citations

The Human Rab Genes Encode a Family of GTP-binding Proteins Related to Yeast YPT1 and SEC4 Products Involved in Secretion

1989 • 387 citations

Posttranslational modification of the Ha-ras oncogene protein: evidence for a third class of protein carboxyl methyltransferases.

1988 • 384 citations

Structure of Saccharomyces cerevisiae mating hormone a-factor. Identification of S-farnesyl cysteine as a structural component.

1988 • 373 citations

Relation of cholesterol and mevalonic acid to the cell cycle in smooth muscle and swiss 3T3 cells stimulated to divide by platelet-derived growth factor.

1980 • 353 citations

Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region.

1988 • 334 citations

Human Lamin B Contains a Farnesylated Cysteine Residue

1989 • 324 citations

Feedback Regulation of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase in Livers of Mice Treated with Mevinolin, a Competitive Inhibitor of the Reductase

1980 • 305 citations

Essential role for mevalonate synthesis in DNA replication

1979 • 297 citations

The ral gene: a new ras related gene isolated by the use of a synthetic probe.

1986 • 264 citations

Evidence for modification of lamin B by a product of mevalonic acid.

1988 • 254 citations

Inhibitory Effects on Lipid Metabolismn in Cultured Cells of ML‐236B, a Potent Inhibitor of 3‐Hydroxt‐3‐methylglutaryl‐Cornzyme‐A Reductase

1978 • 252 citations

Evidence for post-translational incorporation of a product of mevalonic acid into Swiss 3T3 cell proteins.

1984 • 236 citations

Nucleotide and deduced amino acid sequences of a GTP-binding protein family with molecular weights of 25,000 from bovine brain.

1988 • 234 citations

Structural and functional properties of ras proteins

1989 • 211 citations

Purification of the major GTP-binding proteins from human placental membranes.

1986 • 190 citations

A novel small molecular weight GTP-binding protein with the same putative effector domain as the ras proteins in bovine brain membranes. Purification, determination of primary structure, and characterization.

1988 • 185 citations

Incorporation of a product of mevalonic acid metabolism into proteins of Chinese hamster ovary cell nuclei.

1988 • 181 citations

Biochemistry of Interorganelle Transport

1989 • 176 citations

Chemical and immunological characterization of the 21-kDa ADP-ribosylation factor of adenylate cyclase.

1988 • 175 citations

Specific binding of [alpha-32P]GTP to cytosolic and membrane-bound proteins of human platelets correlates with the activation of phospholipase C.

1987 • 157 citations

Relationship between mevalonate and mitogenesis in human fibroblasts stimulated with platelet-derived growth factor.

1984 • 155 citations

The ras-related ypt protein is an ubiquitous eukaryotic protein: isolation and sequence analysis of mouse cDNA clones highly homologous to the yeast YPT1 gene.

1987 • 142 citations

A ras-related protein is phosphorylated and translocated by agonists that increase cAMP levels in human platelets.

1989 • 141 citations

Nuclear lamin LI of Xenopus laevis: cDNA cloning, amino acid sequence and binding specificity of a member of the lamin B subfamily.

1987 • 141 citations

Regulatory Role for GTP-Binding Proteins in Endocytosis

1989 • 138 citations

Isoprenylated proteins in cultured cells: Subcellular distribution and changes related to altered morphology and growth arrest induced by mevalonate deprivation

1987 • 136 citations

Defective macromolecule biosynthesis and cell-cycle progression in a mammalian cell starved for mevalonate.

1985 • 133 citations

Peptidal Sex Hormones Inducing Conjugation Tube Formation in Compatible Mating-Type Cells of Tremella mesenterica

1981 • 125 citations

Cell cycle-dependent methyl esterification of lamin B.

1987 • 116 citations

Characterization and expression of the human rhoH12 gene product.

1989 • 108 citations

The mechanism and regulation of dolichyl phosphate biosynthesis in rat liver.

1986 • 105 citations

Structures of tremerogens A-9291-I and A-9291-VIII: peptidal sex hormones of Tremella brasiliensis

1984 • 99 citations

Purification and characterization of a GTP-binding protein with a molecular weight of 20,000 in bovine brain membranes. Identification as the rho gene product.

1988 • 93 citations

RAS2 protein of Saccharomyces cerevisiae is methyl-esterified at its carboxyl terminus

1989 • 92 citations

Isopentenyladenine as a mediator of mevalonate-regulated DNA replication.

1980 • 91 citations

Post-translational isoprenylation of cellular proteins is altered in response to mevalonate availability

1989 • 89 citations

Differentiation of neuroblastoma cells induced by an inhibitor of mevalonate synthesis: Relation of neurite outgrowth and acetylcholinesterase activity to changes in cell proliferation and blocked isoprenoid synthesis

1985 • 87 citations

Expression of specific high capacity mevalonate transport in a Chinese hamster cell variant.

1987 • 71 citations

Lamin B methylation and assembly into the nuclear envelope

1989 • 70 citations

Identification and purification from bovine brain of a guanine-nucleotide-binding protein distinct from Gs, Gi and Go

1987 • 69 citations

Requirement for mevalonate in cycling cells: Quantitative and temporal aspects

1988 • 69 citations

Isolation of GTP-binding proteins from myeloid HL-60 cells. Identification of two pertussis toxin substrates.

1987 • 66 citations

Characterization of isoprenoid involved in the post-translational modification of mammalian cell proteins

1989 • 65 citations

Linkage of the isoprenoid biosynthetic pathway with induction of DNA synthesis in mouse lymphocytes effects of compactin on mitogen-induced lymphocytes in serum-free medium

1982 • 57 citations

[29] The protein carboxylmethyltransferase involved in Escherichia coli and Salmonella typhimurium chemotaxis

1984 • 55 citations

Cell Cycle‐Specific Requirement for Mevalonate, but Not for Cholesterol, for DNA Synthesis in Glial Primary Cultures

1987 • 54 citations

Relation of mevalonate synthesis to mitochondrial ubiquinone content and respiratory function in cultured neuroblastoma cells.

1985 • 53 citations

Guanine nucleotide-dependent carboxyl methylation of mammalian membrane proteins.

1988 • 49 citations

Enzymatic Methylation of 23-29-kDa Bovine Retinal Rod Outer Segment Membrane Proteins

1989 • 47 citations

Oncogene-Induced Transformation of a Rat Embryo Fibroblast Cell Line is Enhanced by Tumor Promoters

1986 • 46 citations

Multiple genes coding for precursors of rhodotorucine A, a farnesyl peptide mating pheromone of the basidiomycetous yeast Rhodosporidium toruloides.

1989 • 43 citations

Cellular distribution of cholesterogenesis‐linked, phosphoisoprenylated proteins in proliferating cells

1989 • 40 citations

Prenylated proteins from kidney

1986 • 33 citations

Isoprenoid synthesis during the cell cycle. Studies of 3-hydroxy-3-methylglutaryl-coenzyme A synthase and reductase and isoprenoid labeling in cells synchronized by centrifugal elutriation.

1988 • 32 citations

Evidence for Multiple, ras-like, Guanine Nucleotide-binding Proteins in Swiss 3T3 Plasma Membranes

1989 • 19 citations

The role of N-6-isopentenyl adenine in tumor cell growth

1986 • 12 citations

Activity of 3-hydroxy-3-methylglutaryl-coenzyme A reductase does not respond to ubiquinone uptake in cultured cells

1987 • 6 citations