Differentiation of neuroblastoma cells induced by an inhibitor of mevalonate synthesis: Relation of neurite outgrowth and acetylcholinesterase activity to changes in cell proliferation and blocked isoprenoid synthesis

A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES

1957 • 63,238 citations

A new and rapid colorimetric determination of acetylcholinesterase activity

1961 • 25,114 citations

THE DISTRIBUTION AND CHEMICAL COMPOSITION OF ULTRACENTRIFUGALLY SEPARATED LIPOPROTEINS IN HUMAN SERUM

1955 • 8,846 citations

The Low-Density Lipoprotein Pathway and its Relation to Atherosclerosis

1977 • 2,481 citations

Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.

1980 • 1,607 citations

Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth.

1980 • 1,195 citations

Progress in Nucleic Acid Research and Molecular Biology

2001 • 936 citations

Aphidicolin prevents mitotic cell division by interfering with the activity of DNA polymerase-α

1978 • 904 citations

Competitive inhibition of 3‐hydroxy‐3‐methylglutaryl coenzyme a reductase by ML‐236A and ML‐236B fungal metabolites, having hypocholesterolemic activity

1976 • 788 citations

Regulation of HMG-CoA Reductase

1976 • 743 citations

The Role of Polyprenol-Linked Sugars in Glycoprotein Synthesis

1976 • 680 citations

Biological Activity of Some Oxygenated Sterols

1978 • 570 citations

Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase

1978 • 556 citations

ISOLATION OF RAT LIVER PLASMA MEMBRANES

1970 • 506 citations

Suppression of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Activity and Inhibition of Growth of Human Fibroblasts by 7-Ketocholesterol

1974 • 502 citations

Regulation of Axon Formation by Clonal Lines of a Neural Tumor

1970 • 480 citations

Inhibition of mammalian DNA polymerase by the 5'-triphosphate of 1-beta-d-arabinofuranosylcytosine and the 5'-triphosphate of 9-beta-d-arabinofuranoxyladenine.

1968 • 477 citations

Lipid fluidity markedly modulates the binding of serotonin to mouse brain membranes.

1980 • 444 citations

Hydroxyurea: Inhibitory Effect on DNA Metabolism

1964 • 425 citations

Regulation of allosteric membrane-bound enzymes through changes in membrane lipid composition

1975 • 355 citations

Relation of cholesterol and mevalonic acid to the cell cycle in smooth muscle and swiss 3T3 cells stimulated to divide by platelet-derived growth factor.

1980 • 353 citations

Regulation of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Activity in Human Fibroblasts by Lipoproteins

1973 • 348 citations

Feedback Regulation of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase in Livers of Mice Treated with Mevinolin, a Competitive Inhibitor of the Reductase

1980 • 305 citations

Essential role for mevalonate synthesis in DNA replication

1979 • 297 citations

Inhibitory Effects on Lipid Metabolismn in Cultured Cells of ML‐236B, a Potent Inhibitor of 3‐Hydroxt‐3‐methylglutaryl‐Cornzyme‐A Reductase

1978 • 252 citations

The purification and properties of Neurospora malate dehydrogenase

1965 • 238 citations

Evidence for post-translational incorporation of a product of mevalonic acid into Swiss 3T3 cell proteins.

1984 • 236 citations

Regulation of Acetylcholinesterase in Neuroblastoma Cells

1970 • 225 citations

Consequences of blocked sterol synthesis in cultured cells. DNA synthesis and membrane composition.

1977 • 216 citations

Sterol Biosynthesis

1981 • 206 citations

The dual role of mevalonate in the cell cycle.

1983 • 201 citations

Interaction specificity of the anthracyclines with deoxyribonucleic acid

1976 • 199 citations

Alterations in phospholipid-dependent (Na++K+)-ATPase activity due to lipid fluidity

1975 • 196 citations

New concepts on the role of ubiquinone in the mitochondrial respiratory chain

1981 • 194 citations

Inhibition of cholesterol synthesis with compactin renders growth of cultured cells dependent on the low density lipoprotein receptor.

1979 • 186 citations

Biochemistry of Polyisoprenoid Biosynthesis

1976 • 178 citations

A stable propidium iodide staining procedure for flow cytometry.

1982 • 170 citations

Studies related to antitumor antibiotics. Part V. Reactions of mitomycin C with DNA examined by ethidium fluorescence assay

1976 • 167 citations

Relationship between mevalonate and mitogenesis in human fibroblasts stimulated with platelet-derived growth factor.

1984 • 155 citations

Synthesis of ubiquinone and cholesterol in human fibroblasts: Regulation of a branched pathway

1979 • 152 citations

Defective macromolecule biosynthesis and cell-cycle progression in a mammalian cell starved for mevalonate.

1985 • 133 citations

Hydroquinone Dehydrogenases

1977 • 131 citations

Cyclic AMP metabolism in cholesterol-rich platelets.

1977 • 128 citations

Relationship of dolichol synthesis to glycoprotein synthesis during embryonic development.

1981 • 124 citations

Morphological and biochemical study in X-ray- and dibutyryl cyclic AMP-induced differentiated neuroblastoma cells

1972 • 120 citations

Properties of purified rat hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase and regulation of enzyme activity.

1980 • 118 citations

Inter-relationships between dolichol and sterol synthesis in mammalian cell cultures.

1979 • 112 citations

Inhibition of polyisoprenoid and glycoprotein biosynthesis causes abnormal embryonic development.

1979 • 107 citations

Impairment of dolichyl saccharide synthesis and dolichol-mediated glycoprotein assembly in the aortic smooth muscle cell in culture by inhibitors of cholesterol biosynthesis

1978 • 106 citations

Synthesis of delta 2-isopentenyl tRNA from mevalonate in cultured human fibroblasts.

1980 • 104 citations

Depletion of L-cell sterol depresses endocytosis

1976 • 104 citations

N6-(δ2-Isopentenyl)adenosine: Chemical Reactions, Biosynthesis, Metabolism, and Significance to the Structure and Function of †RNA

1970 • 102 citations

An organic phosphorus assay which avoids the use of hazardous perchloric acid

1982 • 100 citations

THE EFFECT OF COLCHICINE ON THE MICROSCOPIC AND SUBMICROSCOPIC STRUCTURE OF THE MITOTIC SPINDLE

2008 • 99 citations

Lipid requirement for cell cycling

1977 • 93 citations

Isopentenyladenine as a mediator of mevalonate-regulated DNA replication.

1980 • 91 citations

Induction of Acetylcholinesterase Activity in Mouse Neuroblastoma Tissue Culture Cells

1971 • 87 citations

Comparison of Surface Membranes Isolated from Cultured Murine Neuroblastoma Cells in the Differentiated or Undifferentiated State

1974 • 85 citations

Neuroblastoma cells recapitulate their detailed neurite morphologies after reversible microtubule disassembly

1980 • 84 citations

Inhibition of mitochondrial oxidative phosphorylation by adriamycin

1983 • 80 citations

ERYTHROCYTE ACETYLCHOLINESTERASE ACTIVITY IN ABO HEMOLYTIC DISEASE OF THE NEWBORN

1964 • 73 citations

A study of the Influence of mevalonic acid and its metabolites on the morphology of swiss 3T3 cells.

1982 • 70 citations

Role of cholesterol metabolism in cell growth.

1984 • 70 citations

Inhibition of degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by mevinolin.

1983 • 65 citations

The role of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in the regulation of ubiquinone synthesis in human fibroblasts.

1980 • 62 citations

A new specific cholesterol assay gives reduced cholesterol/phospholipid molar ratios in cell membranes

1979 • 57 citations

Enzyme Regulation in Neuroblastoma Cells

1972 • 56 citations

Induction of an oligodendroglial enzyme in C‐6 glioma cells maintained at high density or in serum‐free medium

1979 • 54 citations

Relation of mevalonate synthesis to mitochondrial ubiquinone content and respiratory function in cultured neuroblastoma cells.

1985 • 53 citations

Lack of correlation between the rate of cholesterol biosynthesis and the activity of 3-hydroxy-3-methylglutaryl coenzyme A reductase in rats and in fibroblasts treated with ML-236B

1978 • 52 citations

Regulation of hepatic dolichol synthesis by beta-hydroxy-beta-methylglutaryl coenzyme A reductase.

1980 • 50 citations

Membrane fluidity, cholesterol and allosteric transitions of membrane‐bound Mg²⁺‐ATPase, (Na⁺ + K⁺)‐ATPase and acetylcholinesterase from rat erythrocytes

1973 • 49 citations

Neurite outgrowth of neuroblastoma cells: dependence on adhesion surface--cell surface interactions.

1984 • 47 citations

Role of the quinone structure in the mitochondrial damage induced by antitumor anthracyclines

1983 • 42 citations

The activity of 3-hydroxy-3-methylglutaryl coenzyme a reductase and the rate of sterol synthesis diminish in cultures with high cell density

1981 • 42 citations

Modulation of serotonergic receptors by exogenous cholesterol in the dog synaptosomal plasma membrane

1980 • 39 citations

Induction of Neuronal Functions: Acetylcholine-Induced Acetylcholinesterase Activity in Mouse Neuroblastoma Cells

1972 • 39 citations

A glycoprotein from neurites of differentiated neuroblastoma cells.

1980 • 37 citations

Induction of differentiation in murine neuroblastoma cells by mevinolin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase

1984 • 36 citations

Effects of adriamycin on supercoiled DNA and calf thymus nucleosomes studied with fluorescent probes.

1984 • 35 citations

Effects of modulating erythrocyte membrane cholesterol on Rho(D) antigen expression

1980 • 34 citations

Synthesis and turnover of plasma-membrane proteins and glycoproteins in a neuroblastoma cell line

1976 • 34 citations

Microtubules and the regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase.

1979 • 30 citations

Effects of isoleucine deprivation on synthesis of sterols and fatty acids in LM-cells.

1981 • 23 citations

Compartments of tubulin and tubulin-like proteins in differentiating neuroblastoma cells

1979 • 17 citations

Changes in sterol biosynthesis accompanying cessation of glial cell growth in serum-free medium

1980 • 16 citations

Effects of prior sterol depletion on neurite outgrowth in neuroblastoma cells

1981 • 16 citations

Selective decrease of the viability and the sterol content of proliferating versus quiescent glioma cells exposed to 25-hydroxycholesterol.

1981 • 16 citations

Ultrastructural aspects of rapid plasma membrane growth in mitotic neuroblastoma cells.

1983 • 15 citations

Changes in synthesis of sterols and fatty acids associated with inhibition of growth of L-M cells at high cell density

1981 • 15 citations

The regulation of ubiquinone synthesis in fibroblasts: The effect of modulators of β-hydroxy-β-methylglutaryl-coenzyme A reductase activity

1981 • 12 citations

Inhibition of De Novo Sterol Synthesis Does Not Affect Initiation of Neurite Outgrowth in Neuroblastoma

1980 • 10 citations

A simplified procedure for isolating plasma membranes from cultured mouse fibroblast cells: 3T3 and SV-3T3

1978 • 10 citations

A Simple, Inexpensive Apparatus for Quantitative Recovery of Material from Thin-layer Plates

1983 • 10 citations

Aphidicolin, a specific inhibitor of DNA polymerase alpha, inhibits conversion of lanosterol to C-27 sterols in mouse L cells.

1984 • 8 citations

Ultrastructural aspects of rapid plasma membrane growth in mitotic neuro-blastoma cells

1984 • 7 citations