Inhibition of isoprenoid biosynthesis and the post-translational modification of pro-p21.

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

ras GENES

1987 • 3,818 citations

All ras proteins are polyisoprenylated but only some are palmitoylated

1989 • 1,806 citations

Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth.

1980 • 1,195 citations

Important Advances in Oncology: 1986

1986 • 912 citations

cDNA sequencing of nuclear lamins A and C reveals primary and secondary structural homology to intermediate filament proteins.

1986 • 711 citations

Genetic and Pharmacological Suppression of Oncogenic Mutations in RAS Genes of Yeast and Humans

1989 • 535 citations

A solvent system for delipidation of plasma or serum without protein precipitation

1976 • 515 citations

Post-translational processing of p21ras is two-step and involves carboxyl-methylation and carboxy-terminal proteolysis.

1989 • 462 citations

Harvey murine sarcoma virus p21 ras protein: biological and biochemical significance of the cysteine nearest the carboxy terminus.

1984 • 403 citations

Progress in understanding the LDL receptor and HMG-CoA reductase, two membrane proteins that regulate the plasma cholesterol

1984 • 393 citations

Posttranslational modification of the Ha-ras oncogene protein: evidence for a third class of protein carboxyl methyltransferases.

1988 • 384 citations

Structure of Saccharomyces cerevisiae mating hormone a-factor. Identification of S-farnesyl cysteine as a structural component.

1988 • 373 citations

Multivalent control of 3-hydroxy-3-methylglutaryl coenzyme A reductase. Mevalonate-derived product inhibits translation of mRNA and accelerates degradation of enzyme.

1988 • 336 citations

Feedback Regulation of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase in Livers of Mice Treated with Mevinolin, a Competitive Inhibitor of the Reductase

1980 • 305 citations

Essential role for mevalonate synthesis in DNA replication

1979 • 297 citations

Fluorographic detection of radioactivity in polyacrylamide gels with 2,5-diphenyloxazole in acetic acid and its comparison with existing procedures

1983 • 264 citations

Evidence for post-translational incorporation of a product of mevalonic acid into Swiss 3T3 cell proteins.

1984 • 236 citations

Sterol Biosynthesis

1981 • 206 citations

Regulation of synthesis and degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase by low density lipoprotein and 25-hydroxycholesterol in UT-1 cells.

1982 • 203 citations

Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its mRNA in rat liver as studied with a monoclonal antibody and a cDNA probe.

1983 • 200 citations

Amplification of the gene for 3-hydroxy-3-methylglutaryl coenzyme A reductase, but not for the 53-kDa protein, in UT-1 cells.

1983 • 200 citations

Incorporation of a product of mevalonic acid metabolism into proteins of Chinese hamster ovary cell nuclei.

1988 • 181 citations

Isoprenylated proteins in cultured cells: Subcellular distribution and changes related to altered morphology and growth arrest induced by mevalonate deprivation

1987 • 136 citations

Defective macromolecule biosynthesis and cell-cycle progression in a mammalian cell starved for mevalonate.

1985 • 133 citations

Amino acid sequence and molecular characterization of murine lamin B as deduced from cDNA clones.

1988 • 127 citations

Posttranslational processing of p21 ras proteins involves palmitylation of the C-terminal tetrapeptide containing cysteine-186

1985 • 120 citations

Radioimmune precipitation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from Chinese hamster fibroblasts. Effect of 25-hydroxycholesterol.

1981 • 93 citations

Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase synthesis by a non-sterol mevalonate-derived product in Mev-1 cells. Apparent translational control.

1985 • 83 citations

Expression of specific high capacity mevalonate transport in a Chinese hamster cell variant.

1987 • 71 citations

Sterol synthesis in variant Chinese hamster lung cells selected for resistance to 25-hydroxycholesterol. Cross-resistance to 7-ketocholesterol, 20alpha-hydroxycholesterol, and serum.

1979 • 62 citations

Isolation and characterization of a mammalian cell mutant defective in 3-hydroxy-3-methylglutaryl coenzyme A synthase.

1982 • 58 citations

Sterol-independent Regulation of 3-Hydroxy-3-methylglutaryl-CoA Reductase by Mevalonate in Chinese Hamster Ovary Cells

1989 • 46 citations

Isoprenoid synthesis in isolated embryonic Drosophila cells. Sterol-independent regulatory signal molecule is distal to isopentenyl 1-pyrophosphates.

1985 • 43 citations

Amplified DNA sequences in Y1 mouse adrenal tumor cells: association with double minutes and localization to a homogeneously staining chromosomal region.

1982 • 43 citations

Further characterization of a somatic cell mutant defective in regulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase

1988 • 18 citations