Suppression of murine neuroblastoma growth in vivo by mevinolin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

A SIMPLE METHOD FOR THE ISOLATION AND PURIFICATION OF TOTAL LIPIDES FROM ANIMAL TISSUES

1957 • 63,238 citations

A study of the conditions and mechanism of the diphenylamine reaction for the colorimetric estimation of deoxyribonucleic acid

1956 • 14,202 citations

The Low-Density Lipoprotein Pathway and its Relation to Atherosclerosis

1977 • 2,481 citations

Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.

1980 • 1,607 citations

Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth.

1980 • 1,195 citations

Competitive inhibition of 3‐hydroxy‐3‐methylglutaryl coenzyme a reductase by ML‐236A and ML‐236B fungal metabolites, having hypocholesterolemic activity

1976 • 788 citations

Regulation of HMG-CoA Reductase

1976 • 743 citations

Statistical Theory and Methodology in Science and Engineering

1965 • 649 citations

Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes.

1983 • 562 citations

Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase

1978 • 556 citations

Principles of the design and operation of generic osmotic pumps for the delivery of semisolid or liquid drug formulations

1976 • 365 citations

Relation of cholesterol and mevalonic acid to the cell cycle in smooth muscle and swiss 3T3 cells stimulated to divide by platelet-derived growth factor.

1980 • 353 citations

Feedback Regulation of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase in Livers of Mice Treated with Mevinolin, a Competitive Inhibitor of the Reductase

1980 • 305 citations

Essential role for mevalonate synthesis in DNA replication

1979 • 297 citations

Effects of an Inhibitor of 3-Hydroxy-3-Methylglutaryl Coenzyme a Reductase on Serum Lipoproteins and Ubiquinone-10 Levels in Patients with Familial Hypercholesterolemia

1981 • 262 citations

Inhibitory Effects on Lipid Metabolismn in Cultured Cells of ML‐236B, a Potent Inhibitor of 3‐Hydroxt‐3‐methylglutaryl‐Cornzyme‐A Reductase

1978 • 252 citations

The purification and properties of Neurospora malate dehydrogenase

1965 • 238 citations

Evidence for post-translational incorporation of a product of mevalonic acid into Swiss 3T3 cell proteins.

1984 • 236 citations

Therapeutic effects of ML-236B in primary hypercholesterolemia

1980 • 231 citations

Effects of ML-236B on cholesterol metabolism in mice and rats: Lack of hypocholesterolemic activity in normal animals

1979 • 218 citations

Cholesterol-lowering effect of mevinolin, an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme a reductase, in healthy volunteers.

1982 • 206 citations

Sterol Biosynthesis

1981 • 206 citations

The dual role of mevalonate in the cell cycle.

1983 • 201 citations

Reduction of Serum Cholesterol in Heterozygous Patients with Familial Hypercholesterolemia

1983 • 201 citations

Statistical Theory and Methodology in Science and Engineering

1966 • 196 citations

Inhibition of cholesterol synthesis with compactin renders growth of cultured cells dependent on the low density lipoprotein receptor.

1979 • 186 citations

Hypocholesterolemic effects of mevinolin in patients with heterozygous familial hypercholesterolemia.

1984 • 176 citations

Relationship between mevalonate and mitogenesis in human fibroblasts stimulated with platelet-derived growth factor.

1984 • 155 citations

Synthesis of ubiquinone and cholesterol in human fibroblasts: Regulation of a branched pathway

1979 • 152 citations

Alterations in the rates of synthesis and degradation of rat liver 3-hydroxy-3-methylglutaryl coenzyme A reductase produced by cholestyramine and mevinolin.

1983 • 117 citations

Synthesis of delta 2-isopentenyl tRNA from mevalonate in cultured human fibroblasts.

1980 • 104 citations

N6-(δ2-Isopentenyl)adenosine: Chemical Reactions, Biosynthesis, Metabolism, and Significance to the Structure and Function of †RNA

1970 • 102 citations

Rapid and substantial lowering of human serum cholesterol by mevinolin (MK-803), an inhibitor of hydroxymethylglutaryl-coenzyme a reductase

1982 • 94 citations

The characterization and stereochemistry of biosynthesis of dolichols in rat liver

1970 • 78 citations

Cholesterol biosynthesis and 3-hydroxy-3-methyl-glutaryl coenzyme a reductase in cultured glial and neuronal cells

1977 • 68 citations

Inhibition of degradation of 3-hydroxy-3-methylglutaryl coenzyme A reductase by mevinolin.

1983 • 65 citations

The role of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in the regulation of ubiquinone synthesis in human fibroblasts.

1980 • 62 citations

Loss of Feedback Control of Hydroxymethylglutaryl Coenzyme A Reductase in Hepatomas

1971 • 60 citations

A new specific cholesterol assay gives reduced cholesterol/phospholipid molar ratios in cell membranes

1979 • 57 citations

Regulation of the rate of sterol synthesis and the level of beta-hydroxy-beta-methylglutaryl coenzyme A reductase activity in mouse liver and hepatomas.

1971 • 39 citations

Induction of differentiation in murine neuroblastoma cells by mevinolin, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase

1984 • 36 citations

Synthesis of radioactive dolichol from [4S-3H]-mevalonate in the regenerating rat liver

1974 • 35 citations

Biological characterization of the C-1300 murine neuroblastoma: an in vivo neural crest tumor model.

1982 • 30 citations

3‐Hydroxy‐3‐methylglutaryl coenzyme A reductase in human brain tumors

1983 • 26 citations

Partial "feedback control" of beta-hydroxy-beta-methylglutaryl coenzyme A reductase activity in primary hepatocellular carcinomas.

1978 • 22 citations

Lipid composition and 3-hydroxy-3-methylglutaryl-CoA reductase acivity of acinar cell carcinoma of rat pancreas

1983 • 19 citations

Regulation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase in rat liver and Morris hepatomas 5123C, 9618A and 5123t.c.

1982 • 19 citations

Murine neuroblastoma: a model of human disease.

1973 • 18 citations

Effects of prior sterol depletion on neurite outgrowth in neuroblastoma cells

1981 • 16 citations

Therapeutic Effects of ML-236B on Primary Hypercholesterolemia

1980 • 11 citations

Effects of an Inhibitor of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase on Serum Lipoproteins and Ubiquinone-10 Levels in Patients with Familial Hypercholesterolemia

1982 • 9 citations

Hypercholesterolemia Persisting After Distal Ileal Bypass: Response to Mevinolin

1984 • 9 citations

Chemotherapy of a murine neuroblastoma model

1975 • 8 citations

Combination chemotherapy in murine neuroblastoma

1976 • 7 citations