Docking Protein FRS2 Links the Protein Tyrosine Kinase RET and Its Oncogenic Forms with the Mitogen-Activated Protein Kinase Signaling Cascade

Cell Signaling by Receptor Tyrosine Kinases

2010 • 7,477 citations

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

Cell Signaling by Receptor Tyrosine Kinases

2000 • 3,570 citations

Signaling Through Scaffold, Anchoring, and Adaptor Proteins

1997 • 2,268 citations

The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2. International RET mutation consortium analysis

1996 • 1,055 citations

Guanine-nucleotide-releasing factor hSos1 binds to Grb2 and links receptor tyrosine kinases to Ras signalling

1993 • 972 citations

PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas

1990 • 949 citations

A Lipid-Anchored Grb2-Binding Protein That Links FGF-Receptor Activation to the Ras/MAPK Signaling Pathway

1997 • 861 citations

Activation of RET as a Dominant Transforming Gene by Germline Mutations of MEN2A and MEN2B

1995 • 826 citations

The Relationship Between Specific RET Proto-oncogene Mutations and Disease Phenotype in Multiple Endocrine Neoplasia Type 2

1996 • 725 citations

An Alternative to SH2 Domains for Binding Tyrosine-Phosphorylated Proteins

1994 • 501 citations

GDNF Family Neurotrophic Factor Signaling: Four Masters, One Servant?

1999 • 469 citations

Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma.

1994 • 364 citations

FRS2 Proteins Recruit Intracellular Signaling Pathways by Binding to Diverse Targets on Fibroblast Growth Factor and Nerve Growth Factor Receptors

2000 • 355 citations

Ret-dependent and -independent Mechanisms of Glial Cell Line-derived Neurotrophic Factor Signaling in Neuronal Cells

1999 • 322 citations

Binding of Shp2 Tyrosine Phosphatase to FRS2 Is Essential for Fibroblast Growth Factor-Induced PC12 Cell Differentiation

1998 • 322 citations

Stimulation of phosphatidylinositol 3-kinase by fibroblast growth factor receptors is mediated by coordinated recruitment of multiple docking proteins

2001 • 313 citations

GFRα-Mediated Localization of RET to Lipid Rafts Is Required for Effective Downstream Signaling, Differentiation, and Neuronal Survival

2000 • 307 citations

Targeted expression of the ret/PTC1 oncogene induces papillary thyroid carcinomas.

1996 • 292 citations

Signaling Complexes and Protein-Protein Interactions Involved in the Activation of the Ras and Phosphatidylinositol 3-Kinase Pathways by the c-Ret Receptor Tyrosine Kinase

2000 • 252 citations

The RET/PTC3 oncogene: metastatic solid-type papillary carcinomas in murine thyroids.

1998 • 250 citations

Development of thyroid papillary carcinomas secondary to tissue-specific expression of the RET/PTC1 oncogene in transgenic mice.

1996 • 232 citations

The Signaling Adapter FRS-2 Competes with Shc for Binding to the Nerve Growth Factor Receptor TrkA

1999 • 231 citations

Transforming Ability of MEN2A-RET Requires Activation of the Phosphatidylinositol 3-Kinase/AKT Signaling Pathway

2000 • 219 citations

Loss of function effect of RET mutations causing Hirschsprung disease

1995 • 218 citations

The Full Oncogenic Activity of Ret/ptc2 Depends on Tyrosine 539, a Docking Site for Phospholipase Cγ

1996 • 199 citations

A Mutation at Tyrosine 1062 in MEN2A-Ret and MEN2B-Ret Impairs Their Transforming Activity and Association with Shc Adaptor Proteins

1996 • 188 citations

Novel Recognition Motif on Fibroblast Growth Factor Receptor Mediates Direct Association and Activation of SNT Adapter Proteins

1998 • 167 citations

Cytogenetics and molecular genetics of carcinomas arising from thyroid epithelial follicular cells

1996 • 166 citations

Characterization of RET proto-oncogene 3' splicing variants and polyadenylation sites: a novel C-terminus for RET.

1995 • 156 citations

Oncogenic RET Receptors Display Different Autophosphorylation Sites and Substrate Binding Specificities

1996 • 144 citations

The Ret Receptor Protein Tyrosine Kinase Associates with the SH2-containing Adapter Protein Grb10

1995 • 140 citations

The Phosphotyrosine Interaction Domain of Shc Binds an LXNPXY Motif on the Epidermal Growth Factor Receptor

1995 • 137 citations

Molecular heterogeneity of RET loss of function in Hirschsprung's disease.

1996 • 132 citations

Constitutive phosphorylation of Shc proteins in human tumors.

1995 • 130 citations

The TRK and RET tyrosine kinase oncogenes cooperate with ras in the neoplastic transformation of a rat thyroid epithelial cell line.

1993 • 128 citations

Mitogenic Signaling by Ret/ptc2 Requires Association with Enigma via a LIM Domain

1996 • 123 citations

RET alternate splicing influences the interaction of activated RET with the SH2 and PTB domains of Shc, and the SH2 domain of Grb2

1997 • 123 citations

Identification of Shc docking site on Ret tyrosine kinase

1997 • 117 citations

Identification of tyrosine residues that are essential for transforming activity of the ret proto-oncogene with MEN2A or MEN2B mutation.

1996 • 112 citations

The phenotypes associated with ret mutations in the multiple endocrine neoplasia type 2 syndrome.

1999 • 108 citations

cDNA cloning and characterization of ret activated in a human papillary thyroid carcinoma cell line

1990 • 105 citations

An epidermal growth factor receptor/ret chimera generates mitogenic and transforming signals: evidence for a ret-specific signaling pathway

1994 • 102 citations

Grb2 binding to the different isoforms of Ret tyrosine kinase

1998 • 100 citations

Direct Association between the Ret Receptor Tyrosine Kinase and the Src Homology 2-containing Adapter Protein Grb7

1996 • 100 citations

Shc and Enigma Are Both Required for Mitogenic Signaling by Ret/ptc2

1998 • 96 citations

Tyrosine 1062 of RET-MEN2A mediates activation of Akt (protein kinase B) and mitogen-activated protein kinase pathways leading to PC12 cell survival.

2000 • 95 citations

Leucine Zipper-mediated Dimerization Is Essential for the PTC1 Oncogenic Activity

1997 • 80 citations

Two distinct mutations of the RET receptor causing Hirschsprung's disease impair the binding of signalling effectors to a multifunctional docking site

1999 • 57 citations

Constitutive activation of the Ras/MAP kinase pathway and enhanced TCR signaling by targeting the Shc adaptor to membrane rafts

2000 • 54 citations

Overexpression of the HIP gene coding for a heparin/heparan sulfate-binding protein in human thyroid carcinomas.

1998 • 22 citations