The phenotypes associated with ret mutations in the multiple endocrine neoplasia type 2 syndrome.

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

The Neural Crest

1999 • 2,996 citations

A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma

1994 • 1,140 citations

The relationship between specific RET proto-oncogene mutations and disease phenotype in multiple endocrine neoplasia type 2. International RET mutation consortium analysis

1996 • 1,055 citations

Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

1995 • 929 citations

Expression of the c-ret proto-oncogene during mouse embryogenesis

1993 • 831 citations

Specific mutations of the RET proto-oncogene are related to disease phenotype in MEN 2A and FMTC

1994 • 646 citations

Medullary thyroid carcinoma

2000 • 641 citations

Peripheral expression and biological activities of GDNF, a new neurotrophic factor for avian and mammalian peripheral neurons.

1995 • 595 citations

Single missense mutation in the tyrosine kinasecatalytic domain of the RET protooncogene is associated with multiple endocrineneoplasia type 2B.

1994 • 591 citations

Persephin, a Novel Neurotrophic Factor Related to GDNF and Neurturin

1998 • 499 citations

Complementary and Overlapping Expression of Glial Cell Line-Derived Neurotrophic Factor (GDNF), c-ret Proto-Oncogene, and GDNF Receptor-α Indicates Multiple Mechanisms of Trophic Actions in the Adult Rat CNS

1997 • 494 citations

C-Cell Hyperplasia Preceding Medullary Thyroid Carcinoma

1973 • 446 citations

Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains.

1988 • 434 citations

Common origin and developmental dependence on c-ret of subsets of enteric and sympathetic neuroblasts

1996 • 409 citations

A GPI-linked protein that interacts with Ret to form a candidate neurturin receptor

1997 • 397 citations

Neurturin responsiveness requires a GPI-linked receptor and the Ret receptor tyrosine kinase

1997 • 300 citations

Germline mutations in glial cell line-derived neurotrophic factor (GDNF) and RET in a Hirschsprung disease patient

1996 • 277 citations

Somatic mutations in the RET proto‐oncogene in sporadic medullary thyroid carcinoma

1996 • 273 citations

Neurturin and Glial Cell Line-Derived Neurotrophic Factor Receptor-β (GDNFR-β), Novel Proteins Related to GDNF and GDNFR-α with Specific Cellular Patterns of Expression Suggesting Roles in the Developing and Adult Nervous System and in Peripheral Organs

1997 • 256 citations

A novel point mutation in the tyrosine kinase domain of the RET proto-oncogene in sporadic medullary thyroid carcinoma and in a family with FMTC.

1995 • 253 citations

Diverse phenotypes associated with exon 10 mutations of the RET proto-oncogene

1994 • 246 citations

Mutation analysis of the RET receptor tyrosine kinase in Hirschsprung disease

1995 • 243 citations

A New Hot Spot for Mutations in theretProtooncogene Causing Familial Medullary Thyroid Carcinoma and Multiple Endocrine Neoplasia Type 2A¹

1998 • 234 citations

Spatial and temporal expression of the ret proto-oncogene product in embryonic, infant and adult rat tissues.

1995 • 226 citations

RET mutations in exons 13 and 14 of FMTC patients.

1995 • 220 citations

Expression of GDNF Family Receptor Components during Development: Implications in the Mechanisms of Interaction

1998 • 190 citations

Multiple GPI-Anchored Receptors Control GDNF-Dependent and Independent Activation of the c-Ret Receptor Tyrosine Kinase

1998 • 188 citations

Germline mutation of RET codon 883 in two cases of de novo MEN 2B

1997 • 186 citations

Characterization of ret proto-oncogene mRNAs encoding two isoforms of the protein product in a human neuroblastoma cell line.

1990 • 181 citations

Mutations in the RET proto-oncogene and the von Hippel-Lindau disease tumour suppressor gene in sporadic and syndromic phaeochromocytomas.

1995 • 171 citations

Risk and Penetrance of Primary Hyperparathyroidism in Multiple Endocrine Neoplasia Type 2A Families with Mutations at Codon 634 of the RET Proto-Oncogene

1998 • 163 citations

GFRα-4 and the tyrosine kinase Ret form a functional receptor complex for persephin

1998 • 156 citations

Characterization of RET proto-oncogene 3' splicing variants and polyadenylation sites: a novel C-terminus for RET.

1995 • 156 citations

Oncogenic RET Receptors Display Different Autophosphorylation Sites and Substrate Binding Specificities

1996 • 144 citations

Biological properties of Ret with cysteine mutations correlate with multiple endocrine neoplasia type 2A, familial medullary thyroid carcinoma, and Hirschsprung's disease phenotype.

1997 • 138 citations

Development of medullary thyroid carcinoma in transgenic mice expressing the RET protooncogene altered by a multiple endocrine neoplasia type 2A mutation

1997 • 134 citations

Somatic and MEN 2A de novo mutations identified in the RET proto-oncogene by screening of sporadic MTC: s

1994 • 132 citations

RET proto-oncogene mutations in French MEN 2A and FMTC families

1994 • 128 citations

Hirschsprungʼs Disease in a Family with Multiple Endocrine Neoplasia Type 2

1982 • 126 citations

Timing of neuronal death in trkA, trkB and trkC mutant embryos reveals developmental changes in sensory neuron dependence on Trk signalling

1996 • 112 citations

A Novel Point Mutation in the Intracellular Domain of theretProtooncogene in a Family with Medullary Thyroid Carcinoma1

1997 • 105 citations

A compound follicular-parafollicular cell carcinoma of the thyroid: A new tumor entity?

1983 • 104 citations

The different RET-activating capability of mutations of cysteine 620 or cysteine 634 correlates with the multiple endocrine neoplasia type 2 disease phenotype.

1997 • 90 citations

Characterization of the ret proto-oncogene products expressed in mouse L cells.

1993 • 88 citations

Association of multiple endocrine neoplasia type 2 and Hirschsprung disease

1998 • 75 citations

A duplication of 12 bp in the critical cysteine rich domain of the RET proto-oncogene results in a distinct phenotype of multiple endocrine neoplasia type 2A

1997 • 60 citations

Mutational analysis of the RET proto-oncogene in 71 Japanese patients with medullary thyroid carcinoma

1998 • 46 citations

Cys 618 Arg mutation in the RET proto-oncogene associated with familial medullary thyroid carcinoma and maternally transmitted Hirschsprung's disease suggesting a role for imprinting

1997 • 45 citations

Pheochromocytomas and C-cell thyroid neoplasms in transgenic c-mos mice: a model for the human multiple endocrine neoplasia type 2 syndrome.

1992 • 44 citations

Haplotype analysis of MEN 2 mutations

1994 • 24 citations

The GDNF/Neurturin‐Ret multicomponent receptor system

1998 • 2 citations