Cytogenetics and molecular genetics of carcinomas arising from thyroid epithelial follicular cells

p53 Mutations in Human Cancers

1991 • 8,133 citations

Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death

1990 • 3,817 citations

Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis.

1994 • 3,536 citations

Identification of the Hepatocyte Growth Factor Receptor As the c- met Proto-Oncogene Product

1991 • 2,230 citations

Germ-line mutations of the RET proto-oncogene in multiple endocrine neoplasia type 2A

1993 • 1,941 citations

Chromosomal translocations in human cancer

1994 • 1,551 citations

Clinical Implications of the p53 Tumor-Suppressor Gene

1993 • 1,341 citations

Mutations in the RET proto-oncogene are associated with MEN 2A and FMTC

1993 • 1,273 citations

A mutation in the RET proto-oncogene associated with multiple endocrine neoplasia type 2B and sporadic medullary thyroid carcinoma

1994 • 1,140 citations

Two G Protein Oncogenes in Human Endocrine Tumors

1990 • 1,038 citations

PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas

1990 • 949 citations

Catalytic specificity of protein-tyrosine kinases is critical for selective signalling

1995 • 929 citations

Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas

1993 • 907 citations

Expression of the c-ret proto-oncogene during mouse embryogenesis

1993 • 831 citations

Activation of RET as a Dominant Transforming Gene by Germline Mutations of MEN2A and MEN2B

1995 • 826 citations

Activation of a novel human transforming gene, ret, by DNA rearrangement

1985 • 796 citations

A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences

1986 • 795 citations

Mutations of the RET proto-oncogene in Hirschsprung's disease

1994 • 751 citations

Point mutations affecting the tyrosine kinase domain of the RET proto-oncogene in Hirschsprung's disease

1994 • 702 citations

Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-MET.

1991 • 698 citations

High prevalence of mutations of the p53 gene in poorly differentiated human thyroid carcinomas.

1993 • 652 citations

Histological Typing of Thyroid Tumours

1988 • 629 citations

Single missense mutation in the tyrosine kinasecatalytic domain of the RET protooncogene is associated with multiple endocrineneoplasia type 2B.

1994 • 591 citations

Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth-factor receptors.

1987 • 567 citations

p53 modulation of TFIIH–associated nucleotide excision repair activity

1995 • 555 citations

Point mutation within the tyrosine kinase domain of the RET proto-oncogene in multiple endocrine neoplasia type 2B and related sporadic tumours

1994 • 531 citations

Prevention of lung reperfusion injury in rabbits by a monoclonal antibody against interleukin-8

1993 • 529 citations

High frequency of ras oncogene activation in all stages of human thyroid tumorigenesis.

1989 • 414 citations

A new oncogene in human thyroid papillary carcinomas and their lymph-nodal metastases

1987 • 413 citations

Ret oncogene activation in human thyroid neoplasms is restricted to the papillary cancer subtype.

1992 • 391 citations

Gene p53 mutations are restricted to poorly differentiated and undifferentiated carcinomas of the thyroid gland.

1993 • 375 citations

Involvement of the p53 tumor suppressor in repair of u.v.-type DNA damage.

1995 • 365 citations

Molecular characterization of RET/PTC3; a novel rearranged version of the RETproto-oncogene in a human thyroid papillary carcinoma.

1994 • 364 citations

Point Mutations of Ras Oncogenes are an Early Event in Thyroid Tumorigenesis

1990 • 361 citations

ret transforming gene encodes a fusion protein homologous to tyrosine kinases.

1987 • 346 citations

Expression of the trk proto-oncogene is restricted to the sensory cranial and spinal ganglia of neural crest origin in mouse development.

1990 • 342 citations

Mechanism of Activation of the ret Proto-oncogene by Multiple Endocrine Neoplasia 2A Mutations

1995 • 336 citations

Effect of a dominant inhibitory Ha-ras mutation on neuronal differentiation of PC12 cells.

1990 • 327 citations

Overexpression of the c-MET/HGF receptor gene in human thyroid carcinomas.

1992 • 317 citations

Oncogenic rearrangements of the RET proto-oncogene in papillary thyroid carcinomas from children exposed to the Chernobyl nuclear accident.

1995 • 276 citations

High frequency of activation of tyrosine kinase oncogenes in human papillary thyroid carcinoma.

1989 • 272 citations

Presence of mutations in all three ras genes in human thyroid tumors.

1990 • 250 citations

Thyroid cancer in an iodide rich area. A histopathological study

1977 • 240 citations

Molecular Characterization of a Thyroid Tumor-Specific Transforming Sequence Formed by the Fusion of ret Tyrosine Kinase and the Regulatory Subunit RIα of Cyclic AMP-Dependent Protein Kinase A

1993 • 239 citations

The ret proto-oncogene is consistently expressed in human pheochromocytomas and thyroid medullary carcinomas.

1990 • 233 citations

Activated ras oncogenes in human thyroid cancers.

1988 • 233 citations

Thyroid cancer in an iodide rich area.A histopathological study

1977 • 228 citations

TRK-T1 is a novel oncogene formed by the fusion of TPR and TRK genes in human papillary thyroid carcinomas.

1992 • 228 citations

Characterization of an inversion on the long arm of chromosome 10 juxtaposing D10S170 and RET and creating the oncogenic sequence RET/PTC.

1992 • 224 citations

Inverse relationship between trk expression and N-myc amplification in human neuroblastomas.

1992 • 219 citations

Loss of function effect of RET mutations causing Hirschsprung disease

1995 • 218 citations

Frequent activation of ret protooncogene by fusion with a new activating gene in papillary thyroid carcinomas.

1994 • 217 citations

Nerve growth factor: a tale of two receptors.

1993 • 215 citations

gsp mutations in human thyroid tumours.

1991 • 198 citations

The DNA Rearrangement That Generates the TRK-T3 Oncogene Involves a Novel Gene on Chromosome 3 Whose Product Has a Potential Coiled-Coil Domain

1995 • 191 citations

Human ret proto-oncogene mapped to chromosome 10q11.2.

1989 • 189 citations

Characterization of ret proto-oncogene mRNAs encoding two isoforms of the protein product in a human neuroblastoma cell line.

1990 • 181 citations

RasOncogene Mutations in Benign and Malignant Thyroid Neoplasms

1991 • 180 citations

The trk family of tyrosine protein kinase receptors

1991 • 170 citations

Molecular characterization of a thyroid tumor-specific transforming sequence formed by the fusion of ret tyrosine kinase and the regulatory subunit RI alpha of cyclic AMP-dependent protein kinase A.

1993 • 168 citations

In vitro irradiation is able to cause RET oncogene rearrangement.

1993 • 161 citations

High rates of ras codon 61 mutation in thyroid tumors in an iodide-deficient area.

1991 • 139 citations

Cytogenetic and molecular genetic studies of follicular and papillary thyroid cancers.

1991 • 138 citations

p53 Gene Mutations Associated with Anaplastic Transformation of Human Thyroid Carcinomas

1992 • 136 citations

Selective activation of ras oncogenes in follicular and undifferentiated thyroid carcinomas

1994 • 132 citations

Isolation of ret proto-oncogene cDNA with an amino-terminal signal sequence.

1989 • 130 citations

RET activation by germline MEN2A and MEN2B mutations.

1995 • 130 citations

Bcl‐2 protein expression in carcinomas originating from the follicular epithelium of the thyroid gland

1994 • 126 citations

Expression of the ret proto‐oncogene product in human normal and neoplastic tissues of neural crest origin

1994 • 126 citations

Aberrant melanogenesis and melanocytic tumour development in transgenic mice that carry a metallothionein/ret fusion gene.

1991 • 126 citations

Developmental expression of the RET protooncogene.

1994 • 119 citations

Novel mutations of thyrotropin receptor gene in thyroid hyperfunctioning adenomas. Rapid identification by fine needle aspiration biopsy.

1994 • 116 citations

Low rate of ret proto-oncogene activation (PTC/retTPC) in papillary thyroid carcinomas from saudi arabia

1994 • 111 citations

Low Frequency of Rearrangements of the ret and trk Proto‐oncogenes in Japanese Thyroid Papillary Carcinomas

1992 • 109 citations

The ret/PTC oncogene in papillary thyroid carcinoma.

1994 • 103 citations

A Sequence Analysis of the Genomic Regions Involved in the Rearrangements between TPM3 and NTRK1 Genes Producing TRK Oncogenes in Papillary Thyroid Carcinomas

1995 • 103 citations

A t( 10; 17) translocation creates the RET/PTC2 chimeric transforming sequence in papillary thyroid carcinoma

1994 • 97 citations

Frequent occurrence of cytogenetic abnormalities in sporadic nonmedullary thyroid carcinoma

1990 • 97 citations

Chromosome studies in thyroid neoplasia

1989 • 93 citations

Chromosomal changes in thyroid tumors

1990 • 80 citations

trk and ret proto‐oncogene expression in human neuroblastoma specimens: High frequency of trk expression in non‐advanced stages

1993 • 78 citations

A Novel Panel of Antibodies that Segregates Immunocytochemically Poorly Differentiated Carcinoma from Undifferentiated Carcinoma of the Thyroid Gland

1994 • 71 citations

The two genes generating RET/PTC3 are localized in chromosomal band 10q11.2

1994 • 70 citations

The oncogene associated with human papillary thyroid carcinoma (PTC) is assigned to chromosome 10 q11-q12 in the same region as multiple endocrine neoplasia type 2A (MEN2A).

1989 • 66 citations

13 The aetiology of thyroid tumours

1979 • 63 citations

Breakpoint characterization of the ret/PTC oncogene in human papillary thyroid carcinoma

1995 • 59 citations

Cloning and characterization of H4 (D10S170), a gene involved in RET rearrangements in vivo.

1994 • 58 citations

Cytogenetic and molecular genetic characterization of papillary thyroid carcinomas

1992 • 52 citations

Induction of RET Proto-Oncogene Expression in Neuroblastoma Cells Precedes Neuronal Differentiation and Is Not Mediated by Protein Synthesis

1995 • 51 citations

Cytogenetic findings in 18 follicular thyroid adenomas

1993 • 48 citations

Detection of RET oncogene activation in human papillary thyroid carcinomas by in situ hybridisation

1992 • 47 citations

Radiation‐induced thyroid cancer

1993 • 45 citations

Oncogenicity of the ret transforming gene in MMTV/ret transgenic mice.

1990 • 45 citations

Characterization of the NTRK1 Genomic Region Involved in Chromosomal Rearrangements Generating TRK Oncogenes

1993 • 42 citations

A t(2;3)(q12–13;p24–25) in follicular thyroid adenomas

1992 • 39 citations

Refined localization to contiguous regions on chromosome 10q of the two genes (H4 and RET) that form the oncogenic sequence PTC.

1991 • 37 citations

Tyrosines outside the Kinase Core and Dimerization Are Required for the Mitogenic Activity of RET/ptc2

1995 • 36 citations

The human tropomyosin gene involved in the generation of the TRK oncogene maps to chromosome 1q31.

1991 • 28 citations

Refined Localization of the Human TPR Gene to Chromosome 1q25 by in Situ Hybridization

1994 • 25 citations

Localization of the TRK proto-oncogene to human chromosome bands 1q23-1q24.

1991 • 24 citations

Chromosomal aberrations in follicular thyroid carcinoma

1991 • 22 citations

RET/ptc and TRK Oncogenes in Papillary Thyroid Carcinoma

1993 • 4 citations