The TRK and RET tyrosine kinase oncogenes cooperate with ras in the neoplastic transformation of a rat thyroid epithelial cell line.

Molecular Cloning: A Laboratory Manual

2001 • 133,517 citations

A new technique for the assay of infectivity of human adenovirus 5 DNA

1973 • 9,740 citations

Tumorigenic conversion of primary embryo fibroblasts requires at least two cooperating oncogenes

1983 • 2,871 citations

The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain

1986 • 2,020 citations

Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus

1983 • 1,857 citations

The trk proto-oncogene encodes a receptor for nerve growth factor

1991 • 1,396 citations

Oncogenes, antioncogenes, and the molecular bases of multistep carcinogenesis.

1989 • 961 citations

PTC is a novel rearranged form of the ret proto-oncogene and is frequently detected in vivo in human thyroid papillary carcinomas

1990 • 949 citations

A human oncogene formed by the fusion of truncated tropomyosin and protein tyrosine kinase sequences

1986 • 795 citations

Cooperation between oncogenes

1991 • 792 citations

Mechanism of met oncogene activation

1986 • 551 citations

Cloning and expression of the ret proto-oncogene encoding a tyrosine kinase with two potential transmembrane domains.

1988 • 434 citations

High frequency of ras oncogene activation in all stages of human thyroid tumorigenesis.

1989 • 414 citations

A new oncogene in human thyroid papillary carcinomas and their lymph-nodal metastases

1987 • 413 citations

Ret oncogene activation in human thyroid neoplasms is restricted to the papillary cancer subtype.

1992 • 391 citations

A thyroid-specific nuclear protein essential for tissue-specific expression of the thyroglobulin promoter.

1989 • 382 citations

High frequency of activation of tyrosine kinase oncogenes in human papillary thyroid carcinoma.

1989 • 272 citations

Presence of mutations in all three ras genes in human thyroid tumors.

1990 • 250 citations

One- and Two-Step Transformations of Rat Thyroid Epithelial Cells by Retroviral Oncogenes

1987 • 244 citations

TRK-T1 is a novel oncogene formed by the fusion of TPR and TRK genes in human papillary thyroid carcinomas.

1992 • 228 citations

Cloning, chromosomal assignment, and regulation of the rat thyrotropin receptor: expression of the gene is regulated by thyrotropin, agents that increase cAMP levels, and thyroid autoantibodies.

1990 • 225 citations

Characterization of an inversion on the long arm of chromosome 10 juxtaposing D10S170 and RET and creating the oncogenic sequence RET/PTC.

1992 • 224 citations

The zinc finger protein GLI transforms primary cells in cooperation with adenovirus E1A.

1991 • 107 citations

cDNA cloning and characterization of ret activated in a human papillary thyroid carcinoma cell line

1990 • 105 citations

A cell type specific factor recognizes the rat thyroglobulin promoter

1987 • 105 citations

The sequence of 967 amino acids at the carboxyl‐end of rat thyroglobulin

1985 • 95 citations

Reversible inhibition of a thyroid-specific trans-acting factor by Ras.

1991 • 68 citations

The oncogene associated with human papillary thyroid carcinoma (PTC) is assigned to chromosome 10 q11-q12 in the same region as multiple endocrine neoplasia type 2A (MEN2A).

1989 • 66 citations

Dissociation between transformed and differentiated phenotype in rat thyroid epithelial cells after transformation with a temperature-sensitive mutant of the Kirsten murine sarcoma virus.

1983 • 57 citations

Agent-specific ras oncogene activation in rat thyroid tumours.

1988 • 55 citations

Hormonal Regulation of Thyroid Peroxidase In Normal And Transformed Rat Thyroid Cells

1990 • 50 citations

A mos oncogene-containing retrovirus, myeloproliferative sarcoma virus, transforms rat thyroid epithelial cells and irreversibly blocks their differentiation pattern

1985 • 45 citations

Transformation of rat thyroid epithelial cells by kirsten murine sarcoma virus

1981 • 43 citations

Complementation by BCL2 and C-HA-RAS Oncogenes in Malignant Transformation of Rat Embryo Fibroblasts

1990 • 42 citations

Thyrotropin receptor gene expression in oncogene-transfected rat thyroid cells: Correlation between transformation, loss of thyrotropin-dependent growth, and loss of thyrotropin receptor gene expression

1990 • 42 citations

Cooperation between the polyomavirus middle-T-antigen gene and the human c-myc oncogene in a rat thyroid epithelial differentiated cell line: model of in vitro progression.

1988 • 41 citations

Reactivation of thyroglobulin gene expression in transformed thyroid cells by 5-azacytidine

1989 • 39 citations

Refined localization to contiguous regions on chromosome 10q of the two genes (H4 and RET) that form the oncogenic sequence PTC.

1991 • 37 citations

Neoplastic transformation inactivates specific trans-acting factor(s) required for the expression of the thyroglobulin gene.

1988 • 35 citations

The trk oncogene abrogates growth factor requirements and transforms hematopoietic cells.

1989 • 29 citations

Retroviral oncogenes: interrelationships between neoplastic transformation and cell differentiation.

1991 • 17 citations