Tyrosine 1062 of RET-MEN2A mediates activation of Akt (protein kinase B) and mitogen-activated protein kinase pathways leading to PC12 cell survival.

Cellular survival: a play in three Akts

1999 • 4,229 citations

SH2 domains recognize specific phosphopeptide sequences

1993 • 2,685 citations

Cell Survival Promoted by the Ras-MAPK Signaling Pathway by Transcription-Dependent and -Independent Mechanisms

1999 • 1,897 citations

The Role of Phosphoinositide 3-Kinase Lipid Products in Cell Function

1999 • 1,007 citations

AKT/PKB and Other D3 Phosphoinositide-Regulated Kinases: Kinase Activation by Phosphoinositide-Dependent Phosphorylation

1999 • 997 citations

Activation of RET as a Dominant Transforming Gene by Germline Mutations of MEN2A and MEN2B

1995 • 826 citations

Ras signalling and apoptosis

1998 • 559 citations

Akt activation by growth factors is a multiple-step process: the role of the PH domain

1998 • 531 citations

GDNF Family Neurotrophic Factor Signaling: Four Masters, One Servant?

1999 • 469 citations

How receptor tyrosine kinases activate ras

1993 • 393 citations

Ret-dependent and -independent Mechanisms of Glial Cell Line-derived Neurotrophic Factor Signaling in Neuronal Cells

1999 • 322 citations

Signalling by the RET receptor tyrosine kinase and its role in the development of the mammalian enteric nervous system

1999 • 265 citations

Transforming Ability of MEN2A-RET Requires Activation of the Phosphatidylinositol 3-Kinase/AKT Signaling Pathway

2000 • 219 citations

The Full Oncogenic Activity of Ret/ptc2 Depends on Tyrosine 539, a Docking Site for Phospholipase Cγ

1996 • 199 citations

Internucleosomal DNA cleavage and neuronal cell survival/death

1993 • 194 citations

A Mutation at Tyrosine 1062 in MEN2A-Ret and MEN2B-Ret Impairs Their Transforming Activity and Association with Shc Adaptor Proteins

1996 • 188 citations

Oncogenic RET Receptors Display Different Autophosphorylation Sites and Substrate Binding Specificities

1996 • 144 citations

The Ret Receptor Protein Tyrosine Kinase Associates with the SH2-containing Adapter Protein Grb10

1995 • 140 citations

Signalling of the Ret receptor tyrosine kinase through the c-Jun NH2-terminal protein kinases (JNKs): evidence for a divergence of the ERKs and JNKs pathways induced by Ret

1998 • 130 citations

RET alternate splicing influences the interaction of activated RET with the SH2 and PTB domains of Shc, and the SH2 domain of Grb2

1997 • 123 citations

Identification of Shc docking site on Ret tyrosine kinase

1997 • 117 citations

The phenotypes associated with ret mutations in the multiple endocrine neoplasia type 2 syndrome.

1999 • 108 citations

Protein Kinase B Activation and Lamellipodium Formation Are Independent Phosphoinositide 3-Kinase-Mediated Events Differentially Regulated by Endogenous Ras

1998 • 104 citations

Direct Association between the Ret Receptor Tyrosine Kinase and the Src Homology 2-containing Adapter Protein Grb7

1996 • 100 citations

Shc and Enigma Are Both Required for Mitogenic Signaling by Ret/ptc2

1998 • 96 citations

Enhanced Phosphatidylinositol 3-Kinase Activity and High Phosphorylation State of Its Downstream Signalling Molecules Mediated by Ret with the MEN 2B Mutation

1999 • 96 citations

Two distinct mutations of the RET receptor causing Hirschsprung's disease impair the binding of signalling effectors to a multifunctional docking site

1999 • 57 citations

Ret receptor tyrosine kinase activates extracellular signal-regulated kinase 2 in SK-N-MC cells.

1995 • 54 citations

Nerve growth factor induced stimulation of Ras requires Trk interaction with Shc but does not involve phosphoinositide 3-OH kinase

1998 • 53 citations