TH1 and TH2 cells: a historical perspective

Signaling by intrathymic cytokines, not T cell antigen receptors, specifies CD8 lineage choice and promotes the differentiation of cytotoxic-lineage T cells

2010 • 5,969 citations

Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases.

1995 • 5,124 citations

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

A Novel Transcription Factor, T-bet, Directs Th1 Lineage Commitment

2000 • 3,456 citations

Development of T _H 1 CD4 ⁺ T Cells Through IL-12 Produced by Listeria -Induced Macrophages

1993 • 3,140 citations

Predominant T_H2-like Bronchoalveolar T-Lymphocyte Population in Atopic Asthma

1992 • 2,802 citations

The Transcription Factor GATA-3 Is Necessary and Sufficient for Th2 Cytokine Gene Expression in CD4 T Cells

1997 • 2,317 citations

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype Production

1987 • 1,936 citations

Reciprocal Control of T Helper Cell and Dendritic Cell Differentiation

1999 • 1,912 citations

B7-1 and B7-2 costimulatory molecules activate differentially the Th1/Th2 developmental pathways: Application to autoimmune disease therapy

1995 • 1,695 citations

Stat6 Is Required for Mediating Responses to IL-4 and for the Development of Th2 Cells

1996 • 1,618 citations

Essential role of Stat6 in IL-4 signalling

1996 • 1,563 citations

Dendritic cells produce IL-12 and direct the development of Th1 cells from naive CD4+ T cells.

1995 • 1,560 citations

Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets.

1989 • 1,462 citations

Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted State6 gene

1996 • 1,304 citations

IL-4 directs the development of Th2-like helper effectors.

1990 • 1,261 citations

Mast cell lines produce lymphokines in response to cross-linkage of FcεRI or to calcium ionophores

1989 • 1,199 citations

Functional subclasses of T-lymphocytes bearing different Ly antigens. I. The generation of functionally distinct T-cell subclasses is a differentiative process independent of antigen.

1975 • 1,105 citations

Human TH1 and TH2 subsets: doubt no more

1991 • 1,103 citations

The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice.

1992 • 1,029 citations

Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming.

1993 • 991 citations

Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells.

1990 • 954 citations

Regulation of antibody isotype secretion by subsets of antigen-specific helper T cells

1988 • 917 citations

CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3.

1994 • 862 citations

Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones.

1988 • 845 citations

Interleukin 12 is required for the T-lymphocyte-independent induction of interferon gamma by an intracellular parasite and induces resistance in T-cell-deficient hosts.

1993 • 837 citations

Infectious immunological tolerance.

1971 • 811 citations

Evidence for compartmentalization of functional subsets of CD2+ T lymphocytes in atopic patients.

1990 • 807 citations

The effect of antigen dose on CD4+ T helper cell phenotype development in a T cell receptor-alpha beta-transgenic model.

1995 • 768 citations

Differential regulation of T helper phenotype development by interleukins 4 and 10 in an alpha beta T-cell-receptor transgenic system.

1992 • 762 citations

Immunoregulation of cutaneous leishmaniasis. T cell lines that transfer protective immunity or exacerbation belong to different T helper subsets and respond to distinct parasite antigens.

1988 • 713 citations

Purified protein derivative of Mycobacterium tuberculosis and excretory-secretory antigen(s) of Toxocara canis expand in vitro human T cells with stable and opposite (type 1 T helper or type 2 T helper) profile of cytokine production.

1991 • 705 citations

Extent of T cell receptor ligation can determine the functional differentiation of naive CD4+ T cells.

1995 • 699 citations

Stat6-Independent GATA-3 Autoactivation Directs IL-4-Independent Th2 Development and Commitment

2000 • 697 citations

The Proto-Oncogene c-maf Is Responsible for Tissue-Specific Expression of Interleukin-4

1996 • 677 citations

Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4.

1995 • 675 citations

Differential production of interferon-γ and interleukin-4 in response to Th1- and Th2-stimulating pathogens by γδ T cells in vivo

1995 • 672 citations

Transcription Factor GATA-3 Is Differentially Expressed in Murine Th1 and Th2 Cells and Controls Th2-specific Expression of the Interleukin-5 Gene

1997 • 666 citations

Allergen- and bacterial antigen-specific T-cell clones established from atopic donors show a different profile of cytokine production.

1991 • 641 citations

Simultaneous production of IL-2, IL-4, and IFN-gamma by activated human CD4+ and CD8+ T cell clones.

1988 • 509 citations

The CD28-Related Molecule ICOS Is Required for Effective T Cell–Dependent Immune Responses

2000 • 507 citations

Induction of immunological paralysis in two zones of dosage

1964 • 439 citations

IL-4 and IFN (alpha and gamma) exert opposite regulatory effects on the development of cytolytic potential by Th1 or Th2 human T cell clones.

1992 • 430 citations

Encephalitogenic T cells in the B10.PL model of experimental allergic encephalomyelitis (EAE) are of the Th-1 lymphokine subtype

1989 • 390 citations

Lymphokine-mediated regulation of the proliferative response of clones of T helper 1 and T helper 2 cells.

1988 • 389 citations

Essential role for interferon-gamma and interleukin-6 in autoimmune insulin-dependent diabetes in NOD/Wehi mice.

1991 • 381 citations

Interleukin 4 is important in protective immunity to a gastrointestinal nematode infection in mice.

1991 • 376 citations

A new murine CD4+ T cell subset with an unrestricted cytokine profile.

1989 • 374 citations

Thymus and Antigen‐Reactive Cells

1969 • 345 citations

Two distinct types of helper T cells involved in the secondary antibody response: independent and synergistic effects of Ia- and Ia+ helper T cells.

1978 • 316 citations

IL-4 Rapidly Produced by Vβ4 Vα8 CD4+ T Cells Instructs Th2 Development and Susceptibility to Leishmania major in BALB/c Mice

1997 • 315 citations

Cultured NK1.1+ CD4+ T cells produce large amounts of IL-4 and IFN-gamma upon activation by anti-CD3 or CD1.

1997 • 291 citations

Differentiation of human NK cells into NK1 and NK2 subsets.

1998 • 270 citations

Mouse splenic and bone marrow cell populations that express high-affinity Fc epsilon receptors and produce interleukin 4 are highly enriched in basophils.

1991 • 259 citations

Alloreactive murine CD8+ T cell clones secrete the Th1 pattern of cytokines.

1990 • 240 citations

Immunologic Complementation between Thymus and Marrow Cells—A Model for the Two‐Cell Theory of Immunocompetence

1969 • 240 citations

Role of interleukin 1 in the activation of T lymphocytes.

1988 • 231 citations

IMMUNE RESPONSE TO CHEMICALLY MODIFIED FLAGELLIN

1971 • 230 citations

Cutting Edge: Differentiation of Human NK Cells into NK1 and NK2 Subsets

1998 • 225 citations

Selective and specific inhibition of 24 hour skin reactions in the guinea-pig. I. Immune deviation: description of the phenomenon and the effect of splenectomy.

1965 • 214 citations

Immunological regulation of experimental cutaneous leishmaniasis. IV. Prophylactic effect of sublethal irradiation as a result of abrogation of suppressor T cell generation in mice genetically susceptible to leishmania tropica

1981 • 199 citations

IMMUNE RESPONSE TO CHEMICALLY MODIFIED FLAGELLIN

1972 • 196 citations

Stat6 Regulation of In Vivo IL-4 Responses

2000 • 194 citations

Ly antigens as markers for functionally distinct subpopulations of thymus-derived lymphocytes of the mouse

1975 • 191 citations

Functional heterogeneity of CD4+ T cells in leishmaniasis

1989 • 171 citations

Induction of interleukin 4 (IL-4) expression in T helper (Th) cells is not dependent on IL-4 from non-Th cells.

1994 • 158 citations

The role of interleukin-5 in protective immunity to Strongyloides venezuelensis infection in mice.

1991 • 126 citations

Immunological Unresponsiveness Produced in Adult Guinea Pigs by Parenteral Introduction of Minute Quantities of Hapten or Protein Antigen.

1962 • 124 citations

Clones of alloreactive T cells

1978 • 115 citations

Coexpression of granulocyte-macrophage colony-stimulating factor, gamma interferon, and interleukins 3 and 4 is random in murine alloreactive T-lymphocyte clones.

1988 • 106 citations

Uptake of microparticle‐adsorbed protein antigen by bone marrow‐derived dendritic cells results in up‐regulation of interleukin‐1α and interleukin‐12 p40/p35 and triggers prolonged, efficient antigen presentation

1995 • 98 citations

Antigen-specific and nonspecific mediators of T cell/B cell cooperation. I. Evidence for their production by different T cells.

1975 • 94 citations

Antigen-specific and nonspecific mediators of T cell/B cell cooperation. III. Characterization of the nonspecific mediator(s) from different sources.

1976 • 85 citations

A T helper cell for anti-viral cytotoxic T-cell responses.

1979 • 79 citations

Cellular cooperation during in vivo anti-hapten antibody responses. I. The effect of cell number on the response.

1975 • 77 citations

Chronic melatonin treatment and the hypothalamo-pituitary-adrenal axis in the rat: attenuation of the secretory response to stress and effects on hypothalamic neuropeptide content and release.

1997 • 73 citations

Inhibition of delayed hypersensitivity by pre-immunization without complete adjuvant.

1966 • 56 citations

Antigen-Specific and Nonspecific Mediators of T Cell/B Cell Cooperation

1975 • 55 citations

Cellular Cooperation During in Vivo Anti-Hapten Antibody Responses

1975 • 51 citations

LACK OF A CORRELATION BETWEEN CELL-MEDIATED IMMUNITY TO THE CARRIER AND THE CARRIER-HAPTEN HELPER EFFECT

1974 • 44 citations

Evidence for non-identity of T killer and T helper cells sensitised to allogeneic cell antigens

1974 • 35 citations

Split tolerance affecting delayed hypersensitivity and induced in mice by pre-immunization with protein antigens in solution.

1966 • 32 citations

Induction of tuberculin hypersensitivity and serologic unresponsiveness to tubercle bacilli in newborn and young guinea pigs.

1968 • 6 citations

Induction of Tuberculin Hypersensitivity and Serologic Unresponsiveness to Tubercle Bacilli in Newborn and Young Cuinea Pigs

1968 • 3 citations

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