IL-7: maintaining T-cell memory and achieving homeostasis

Lineage relationship and protective immunity of memory CD8 T cell subsets

2003 • 1,833 citations

Selective expression of the interleukin 7 receptor identifies effector CD8 T cells that give rise to long-lived memory cells

2003 • 1,790 citations

CD4+ T cells are required for secondary expansion and memory in CD8+ T lymphocytes

2003 • 1,623 citations

Interleukin-7 mediates the homeostasis of naïve and memory CD8 T cells in vivo

2000 • 1,596 citations

Direct Regulation of the Akt Proto-Oncogene Product by Phosphatidylinositol-3,4-bisphosphate

1997 • 1,448 citations

Memory CD8+ T cell differentiation: initial antigen encounter triggers a developmental program in naïve cells

2001 • 1,277 citations

Defective CD8 T Cell Memory Following Acute Infection Without CD4 T Cell Help

2003 • 1,220 citations

Dual Role of Phosphatidylinositol-3,4,5-trisphosphate in the Activation of Protein Kinase B

1997 • 1,190 citations

IL-7 is critical for homeostatic proliferation and survival of naïve T cells

2001 • 940 citations

Naïve CTLs require a single brief period of antigenic stimulation for clonal expansion and differentiation

2001 • 861 citations

Interleukin (IL)-15 and IL-7 Jointly Regulate Homeostatic Proliferation of Memory Phenotype CD8+ Cells but Are Not Required for Memory Phenotype CD4+ Cells

2002 • 783 citations

The role of shared receptor motifs and common stat proteins in the generation of cytokine pleiotropy and redundancy by IL-2, IL-4, IL-7, IL-13, and IL-15

1995 • 760 citations

Persistence of Memory CD8 T Cells in MHC Class I-Deficient Mice

1999 • 738 citations

Interleukin 15 Is Required for Proliferative Renewal of Virus-specific Memory CD8 T Cells

2002 • 671 citations

Bcl-2 Rescues T Lymphopoiesis in Interleukin-7 Receptor–Deficient Mice

1997 • 603 citations

Cutting Edge: Requirement for IL-15 in the Generation of Primary and Memory Antigen-Specific CD8 T Cells

2002 • 519 citations

Increased production of IL-7 accompanies HIV-1–mediated T-cell depletion: implications for T-cell homeostasis

2001 • 519 citations

Interleukin-7: from bench to clinic

2002 • 496 citations

Suppression of IL7Rα Transcription by IL-7 and Other Prosurvival Cytokines

2004 • 472 citations

Selective expression of IL-7 receptor on memory T cells identifies early CD40L-dependent generation of distinct CD8 ⁺ memory T cell subsets

2004 • 466 citations

Interleukin 7 and T cell receptor signals regulate homeostasis of CD4 memory cells

2003 • 454 citations

Interleukin 7 Regulates the Survival and Generation of Memory CD4 Cells

2003 • 449 citations

Class II-Independent Generation of CD4 Memory T Cells from Effectors

1999 • 422 citations

A potential role for interleukin-7 in T-cell homeostasis

2001 • 415 citations

Cutting Edge: CD4 and CD8 T Cells Are Intrinsically Different in Their Proliferative Responses

2002 • 402 citations

Self-recognition promotes the foreign antigen sensitivity of naive T lymphocytes

2002 • 390 citations

Interleukin 7 is produced by human intestinal epithelial cells and regulates the proliferation of intestinal mucosal lymphocytes.

1995 • 376 citations

Control of T Cell Viability

2004 • 367 citations

IL-7 Promotes the Transition of CD4 Effectors to Persistent Memory Cells

2003 • 307 citations

Interleukin 4 (IL-4) or IL-7 Prevents the Death of Resting T Cells: Stat6 Is Probably Not Required for the Effect of IL-4

1997 • 293 citations

Distinct lineages of TH1 cells have differential capacities for memory cell generation in vivo

2002 • 289 citations

A Role for Thymic Stromal Lymphopoietin in CD4+ T Cell Development

2004 • 227 citations

I<scp>mmunological</scp>M<scp>emory to</scp>V<scp>iral</scp>I<scp>nfections</scp>

2004 • 213 citations

Distinct Roles of the Phosphatidylinositol 3-Kinase and STAT5 Pathways in IL-7-Mediated Development of Human Thymocyte Precursors

1999 • 205 citations

IL-7 regulates basal homeostatic proliferation of antiviral CD4 ⁺ T cell memory

2004 • 197 citations

CD8αα-Mediated Survival and Differentiation of CD8 Memory T Cell Precursors

2004 • 191 citations

CD4+ T cell effectors can become memory cells with high efficiency and without further division

2001 • 186 citations

Impairment of immunological memory in the absence of MHC despite survival of memory T cells

2002 • 181 citations

IL-2 negatively regulates IL-7 receptor α chain expression in activated T lymphocytes

2002 • 176 citations

Age-associated thymic atrophy is linked to a decline in IL-7 production

2002 • 174 citations

Two Distinct Stages in the Transition from Naive CD4 T Cells to Effectors, Early Antigen-Dependent and Late Cytokine-Driven Expansion and Differentiation

2000 • 161 citations

The Interleukin (IL)‐2 Family Cytokines: Survival and Proliferation Signaling Pathways in T Lymphocytes

2004 • 160 citations

Interleukin‐7 induces the association of phosphatidylinositol 3‐kinase with the α chain of the interleukin‐7 receptor

1994 • 131 citations

T lymphocytes need IL-7 but not IL-4 or IL-6 to survive in vivo

2001 • 128 citations

Interleukin‐7 expression during mouse thymus development

1992 • 112 citations

Constitutive Expression of Interleukin-7 mRNA and Production of IL-7 by a Cloned Murine Thymic Stromal Cell Line

1990 • 68 citations

Death and Baxes: mechanisms of lymphotrophic cytokines

2003 • 64 citations

T Cell Responses to Influenza Virus Infection: Effector and Memory Cells

2004 • 64 citations

Withdrawal of Stimulation May Initiate the Transition of Effector to Memory CD4 Cells

2002 • 58 citations

Antigen challenge leads toin vivoactivation and elimination of highly polarized TH1 memory T cells

2002 • 56 citations

Interleukin-7 induces T cell proliferation in the absence of Erk/MAP kinase activity

1996 • 52 citations

CD8+ T cells responding to influenza infection reach and persist at higher numbers than CD4+ T cells independently of precursor frequency

2004 • 35 citations

CD4 T cells guarantee optimal competitive fitness of CD8 memory T cells

2003 • 33 citations