In Vivo Priming of Cd4 T Cells That Produce Interleukin (Il)-2 but Not IL-4 or Interferon (Ifn)-γ, and Can Subsequently Differentiate into IL-4–Or IFN-γ–Secreting Cells

Two subsets of memory T lymphocytes with distinct homing potentials and effector functions

1999 • 5,659 citations

The expanding universe of T-cell subsets: Th1, Th2 and more

1996 • 3,710 citations

A CD4+T-cell subset inhibits antigen-specific T-cell responses and prevents colitis

1997 • 3,625 citations

Regulatory T Cell Clones Induced by Oral Tolerance: Suppression of Autoimmune Encephalomyelitis

1994 • 1,995 citations

INDUCTION OF TH1 AND TH2 CD4⁺T CELL RESPONSES:The Alternative Approaches

1997 • 1,464 citations

Two types of mouse helper T cell clone. III. Further differences in lymphokine synthesis between Th1 and Th2 clones revealed by RNA hybridization, functionally monospecific bioassays, and monoclonal antibodies.

1987 • 1,060 citations

Visualizing the generation of memory CD4 T cells in the whole body

2001 • 1,029 citations

T CELL MEMORY

1998 • 863 citations

Regulation of Immunity to Parasites by T Cells and T Cell-Derived Cytokines

1992 • 843 citations

Two types of mouse helper T-cell clone

1987 • 813 citations

Physiological Actions and Clinical Applications of Transforming Growth Factor-β (TGF-β)

1993 • 755 citations

Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1

1985 • 749 citations

CYTOKINE REGULATION OF HOST DEFENSE AGAINST PARASITIC GASTROINTESTINAL NEMATODES:Lessons from Studies with Rodent Models^*

1997 • 648 citations

Direct demonstration of cytokine synthesis heterogeneity among human memory/effector T cells by flow cytometry

1995 • 561 citations

Simultaneous production of IL-2, IL-4, and IFN-gamma by activated human CD4+ and CD8+ T cell clones.

1988 • 509 citations

Distinction of virgin and memory T lymphocytes. Stable acquisition of the Pgp-1 glycoprotein concomitant with antigenic stimulation.

1987 • 505 citations

A new foreign policy: MHC class I molecules monitor the outside world

1996 • 422 citations

Differentiation of T cell lymphokine gene expression: the in vitro acquisition of T cell memory.

1991 • 406 citations

Heterogeneity of mouse helper T cells. Evidence from bulk cultures and limiting dilution cloning for precursors of Th1 and Th2 cells.

1990 • 386 citations

A new murine CD4+ T cell subset with an unrestricted cytokine profile.

1989 • 374 citations

Flow cytometric determination of cytokines in activated murine T helper lymphocytes: Expression of interleukin‐10 in interferon‐γ and in interleukin‐4‐expressing cells

1994 • 305 citations

Single IL-2-secreting precursor CD4 T cell can develop into either Th1 or Th2 cytokine secretion phenotype.

1994 • 282 citations

Resting Memory CD8+ T Cells are Hyperreactive to Antigenic Challenge In Vitro

1996 • 241 citations

Profiles of lymphokine activities and helper function for IgE in human T cell clones

1988 • 204 citations

Migration and Function of Antigen-Primed Nonpolarized T Lymphocytes in Vivo

2001 • 176 citations

Single-Cytokine-Producing CD4 Memory Cells Predominate in Type 1 and Type 2 Immunity

2000 • 174 citations

Heterogeneity of single cell cytokine gene expression in clonal T cell populations.

1994 • 173 citations

Long-term CD4+ memory T cells from the spleen lack MEL-14, the lymph node homing receptor.

1992 • 165 citations

Species-specificity of T cell stimulating activities of IL 2 and BSF-1 (IL 4): comparison of normal and recombinant, mouse and human IL 2 and BSF-1 (IL 4).

1987 • 161 citations

A common precursor for CD4+ T cells producing IL-2 or IL-4.

1992 • 153 citations

Monoclonal antibodies against murine gamma interferon.

1984 • 153 citations

Single cell analysis of cytokine gene coexpression during CD4+ T-cell phenotype development.

1995 • 146 citations

The cytokines IL-4, IFN-gamma, and IL-12 regulate the development of subsets of memory effector helper T cells in vitro.

1995 • 106 citations

Distinct regulation of lymphokine production is found in fresh versus in vitro primed murine helper T cells.

1990 • 99 citations

Single-cell analysis by RT-PCR reveals differential expression of multiple type 1 and 2 cytokine genes among cells within polarized CD4+ T cell populations

1999 • 61 citations

Segregation of type 1 cytokine production in human peripheral blood lymphocytes: phenotypic differences between IFN-γ and IL-2-producing cells in the CD8+ T cell subset

1998 • 20 citations

Primed and replicating but uncommitted T helper precursor cells show kinetics of differentiation and commitment similar to those of naive T helper cells

1999 • 12 citations