G-protein-coupled receptor regulation: role of G-protein-coupled receptor kinases and arrestins

Heterotrimeric C proteins: Organizers of transmembrane signals

1995 • 1,388 citations

MODEL SYSTEMS FOR THE STUDY OF SEVEN-TRANSMEMBRANE-SEGMENT RECEPTORS

1991 • 1,357 citations

β-Arrestin: a Protein that Regulates β-adrenergic Receptor Function

1990 • 1,162 citations

NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor.

1990 • 944 citations

Role of β-Arrestin in Mediating Agonist-Promoted G Protein-Coupled Receptor Internalization

1996 • 938 citations

Somatic mutations in the thyrotropin receptor gene cause hyperfunctioning thyroid adenomas

1993 • 907 citations

Altered expression of beta-adrenergic receptor kinase and beta 1-adrenergic receptors in the failing human heart.

1993 • 877 citations

Pigmentation phenotypes of variant extension locus alleles result from point mutations that alter MSH receptor function

1993 • 873 citations

Phosphodiesterase activation by photoexcited rhodopsin is quenched when rhodopsin is phosphorylated and binds the intrinsic 48-kDa protein of rod outer segments.

1986 • 781 citations

A constitutively activating mutation of the luteinizing hormone receptor in familial male precocious puberty

1993 • 747 citations

Cardiac Function in Mice Overexpressing the β-Adrenergic Receptor Kinase or a βARK Inhibitor

1995 • 714 citations

Role of βγ Subunits of G Proteins in Targeting the β-Adrenergic Receptor Kinase to Membrane-Bound Receptors

1992 • 703 citations

Beta-arrestin2, a novel member of the arrestin/beta-arrestin gene family.

1992 • 531 citations

Protein kinases that phosphorylate activated G protein‐coupled receptors

1995 • 520 citations

Structure and mechanism of the G protein-coupled receptor kinases.

1993 • 480 citations

Binding of G protein beta gamma-subunits to pleckstrin homology domains.

1994 • 479 citations

Functional desensitization of the isolated beta-adrenergic receptor by the beta-adrenergic receptor kinase: potential role of an analog of the retinal protein arrestin (48-kDa protein).

1987 • 478 citations

The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase.

1993 • 467 citations

β-Adrenergic Receptor Kinase: Primary Structure Delineates a Multigene Family

1989 • 451 citations

Dynamin and β-Arrestin Reveal Distinct Mechanisms for G Protein-coupled Receptor Internalization

1996 • 450 citations

Ligand-regulated internalization and recycling of human beta 2-adrenergic receptors between the plasma membrane and endosomes containing transferrin receptors.

1992 • 445 citations

Molecular mechanisms of membrane receptor desensitization

1993 • 442 citations

G protein—coupled receptor kinases

1993 • 434 citations

Removal of phosphorylation sites from the β2-adrenergic receptor delays onset of agonist-promoted desensitization

1988 • 429 citations

Phosphorylation Sites on Two Domains of the β2-Adrenergic Receptor Are Involved in Distinct Pathways of Receptor Desensitization

1989 • 415 citations

Multiple pathways of rapid beta 2-adrenergic receptor desensitization. Delineation with specific inhibitors.

1990 • 393 citations

Beta-adrenergic receptor sequestration. A potential mechanism of receptor resensitization.

1993 • 387 citations

Arrestin Interactions with G Protein-coupled Receptors

1995 • 385 citations

A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated beta 2-adrenergic receptor sequestration.

1994 • 361 citations

Pleckstrin Homology Domain-mediated Membrane Association and Activation of the β-Adrenergic Receptor Kinase Requires Coordinate Interaction with Gβγ Subunits and Lipid

1995 • 360 citations

Sequestration and recycling of beta 2-adrenergic receptors permit receptor resensitization.

1995 • 343 citations

Receptor-specific desensitization with purified proteins. Kinase dependence and receptor specificity of beta-arrestin and arrestin in the beta 2-adrenergic receptor and rhodopsin systems.

1992 • 330 citations

Arrestin Function in Inactivation of G Protein-Coupled Receptor Rhodopsin in Vivo

1993 • 313 citations

Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases

1992 • 306 citations

Visual arrestin interaction with rhodopsin. Sequential multisite binding ensures strict selectivity toward light-activated phosphorylated rhodopsin

1993 • 303 citations

Expression of beta-arrestins and beta-adrenergic receptor kinases in the failing human heart.

1994 • 300 citations

Mechanisms of Rhodopsin Inactivation in Vivo as Revealed by a COOH-Terminal Truncation Mutant

1995 • 299 citations

The G-Protein Linked Receptor Facts Book

1994 • 292 citations

Down-regulation of beta-adrenergic receptors: agonist-induced reduction in receptor mRNA levels.

1988 • 268 citations

Dual pathways of internalization of the cholecystokinin receptor.

1995 • 236 citations

Constitutively active mutants of the alpha 2-adrenergic receptor

1993 • 234 citations

Overexpression of beta-arrestin and beta-adrenergic receptor kinase augment desensitization of beta 2-adrenergic receptors.

1993 • 234 citations

Structural basis for receptor subtype-specific regulation revealed by a chimeric beta 3/beta 2-adrenergic receptor.

1993 • 227 citations

Agonist-dependent phosphorylation of the mouse delta-opioid receptor: involvement of G protein-coupled receptor kinases but not protein kinase C.

1995 • 222 citations

Phosphorylation/dephosphorylation of the beta-adrenergic receptor regulates its functional coupling to adenylate cyclase and subcellular distribution.

1986 • 221 citations

Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family

1991 • 214 citations

Role of Phosphorylation in Agonist-promoted β2-Adrenergic Receptor Sequestration

1995 • 213 citations

Delineation of the endocytic pathway of substance P and its seven-transmembrane domain NK1 receptor.

1995 • 209 citations

Sequential phosphorylation of rhodopsin at multiple sites

1993 • 204 citations

Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases.

1994 • 202 citations

β-Adrenergic Receptor Kinase-2 and β-Arrestin-2 as Mediators of Odorant-Induced Desensitization

1993 • 201 citations

Primary and secondary structure of bovine retinal S antigen (48-kDa protein).

1987 • 200 citations

The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain

1992 • 197 citations

Isoprenylation of a protein kinase. Requirement of farnesylation/alpha-carboxyl methylation for full enzymatic activity of rhodopsin kinase.

1992 • 196 citations

Characterization of the G Protein-coupled Receptor Kinase GRK4

1996 • 193 citations

The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase.

1991 • 189 citations

Identification of a cytoplasmic Ser-Thr-Leu motif that determines agonist-induced internalization of the AT1 angiotensin receptor.

1994 • 186 citations

A beta-adrenergic receptor kinase dominant negative mutant attenuates desensitization of the beta 2-adrenergic receptor.

1994 • 182 citations

Comparative rates of desensitization of beta-adrenergic receptors by the beta-adrenergic receptor kinase and the cyclic AMP-dependent protein kinase.

1991 • 175 citations

Cone arrestin identified by targeting expression of a functional family.

1994 • 172 citations

A small region of the beta-adrenergic receptor is selectively involved in its rapid regulation.

1991 • 166 citations

Protein kinase cross-talk: membrane targeting of the beta-adrenergic receptor kinase by protein kinase C.

1996 • 165 citations

Phosphorylation and Activation of β-Adrenergic Receptor Kinase by Protein Kinase C

1995 • 160 citations

Cloning and expression of GRK5: a member of the G protein-coupled receptor kinase family.

1993 • 159 citations

Effects of Second Intracellular Loop Mutations on Signal Transduction and Internalization of the Gonadotropin-releasing Hormone Receptor

1995 • 158 citations

Polypeptide variants of beta-arrestin and arrestin3

1993 • 156 citations

Desensitization and Internalization of the m2 Muscarinic Acetylcholine Receptor Are Directed by Independent Mechanisms

1995 • 155 citations

Internalization of beta-adrenergic receptor in A431 cells involves non-coated vesicles.

1989 • 155 citations

Mechanisms of desensitization and resensitization of G protein-coupled neurokinin1 and neurokinin2 receptors.

1996 • 154 citations

The Conserved Seven-Transmembrane Sequence NP(X)2,3Y of the G-Protein-Coupled Receptor Superfamily Regulates Multiple Properties of the .beta.2-Adrenergic Receptor

1995 • 151 citations

Sequestration of muscarinic acetylcholine receptor m2 subtypes. Facilitation by G protein-coupled receptor kinase (GRK2) and attenuation by a dominant-negative mutant of GRK2.

1994 • 150 citations

A beta-adrenergic receptor kinase-like enzyme is involved in olfactory signal termination.

1993 • 146 citations

The carboxyl terminus of the hamster β-adrenergic receptor expressed in mouse L cells is not required for receptor sequestration

1987 • 142 citations

Palmitoylation of G protein-coupled receptor kinase, GRK6. Lipid modification diversity in the GRK family.

1994 • 141 citations

Molecular cloning and expression of GRK6. A new member of the G protein-coupled receptor kinase family.

1993 • 139 citations

Independence of type I angiotensin II receptor endocytosis from G protein coupling and signal transduction.

1994 • 136 citations

Arrestin-rhodopsin interaction. Multi-site binding delineated by peptide inhibition.

1994 • 136 citations

Mutations of the human beta 2-adrenergic receptor that impair coupling to Gs interfere with receptor down-regulation but not sequestration.

1991 • 136 citations

Regulation of Rhodopsin Dephosphorylation by Arrestin

1989 • 134 citations

The Cytoplasmic Tail of the G-protein-coupled Receptor for Parathyroid Hormone and Parathyroid Hormone-related Protein Contains Positive and Negative Signals for Endocytosis

1995 • 133 citations

Truncation of the receptor carboxyl terminus impairs agonist-dependent phosphorylation and desensitization of the alpha 1B-adrenergic receptor.

1994 • 132 citations

A mutation of the beta 2-adrenergic receptor impairs agonist activation of adenylyl cyclase without affecting high affinity agonist binding. Distinct molecular determinants of the receptor are involved in physical coupling to and functional activation of Gs.

1990 • 130 citations

Stable Expression of a Truncated AT1A Receptor in CHO-K1 Cells

1995 • 129 citations

A constitutively active mutant beta 2-adrenergic receptor is constitutively desensitized and phosphorylated.

1994 • 129 citations

Sites in the third intracellular loop of the alpha 2A-adrenergic receptor confer short term agonist-promoted desensitization. Evidence for a receptor kinase-mediated mechanism.

1992 • 129 citations

A 49-Kilodalton Phosphoprotein in the Drosophila Photoreceptor Is an Arrestin Homolog

1990 • 128 citations

Regulation of G Protein-Coupled Receptors by Receptor Kinases and Arrestins

1995 • 128 citations

Constitutive activation of phototransduction by K296E opsin is not a cause of photoreceptor degeneration.

1995 • 128 citations

A Conserved NPLFY Sequence Contributes to Agonist Binding and Signal Transduction but Is Not an Internalization Signal for the Type 1 Angiotensin II Receptor

1995 • 127 citations

High expression of beta-adrenergic receptor kinase in human peripheral blood leukocytes. Isoproterenol and platelet activating factor can induce kinase translocation.

1992 • 123 citations

Four Consecutive Serines in the Third Intracellular Loop Are the Sites for β-Adrenergic Receptor Kinase-mediated Phosphorylation and Desensitization of the α2A-Adrenergic Receptor

1995 • 122 citations

X‐Arrestin: a new retinal arrestin mapping to the X chromosome

1993 • 116 citations

Molecular analysis of human beta-arrestin-1: cloning, tissue distribution, and regulation of expression. Identification of two isoforms generated by alternative splicing

1993 • 111 citations

Palmitoylation of luteinizing hormone/human choriogonadotropin receptors in transfected cells. Abolition of palmitoylation by mutation of Cys-621 and Cys-622 residues in the cytoplasmic tail increases ligand-induced internalization of the receptor.

1994 • 111 citations

Serine- and threonine-rich domain regulates internalization of muscarinic cholinergic receptors.

1993 • 109 citations

Visualization of the thyrotropin-releasing hormone receptor and its ligand during endocytosis and recycling.

1995 • 106 citations

Serines and threonines in the gastrin-releasing peptide receptor carboxyl terminus mediate internalization.

1993 • 105 citations

G Protein‐Coupled Receptor Kinases

1994 • 104 citations

Genetic analysis of beta-adrenergic receptor internalization and down-regulation.

1985 • 102 citations

Endothelin-induced Endocytosis of Cell Surface ET @! Receptors

1995 • 102 citations

Amino acid sequences Gly-Pro-Leu-Tyr and Asn-Pro-Glu-Tyr in the submembranous domain of the insulin receptor are required for normal endocytosis.

1991 • 101 citations

Role of the carboxyl-terminal region of arrestin in binding to phosphorylated rhodopsin

1991 • 100 citations

Phospholipid-stimulated autophosphorylation activates the G protein-coupled receptor kinase GRK5.

1994 • 99 citations

Olfactory desensitization requires membrane targeting of receptor kinase mediated by beta gamma-subunits of heterotrimeric G proteins.

1994 • 99 citations

Constitutive Activation of Opsin: Interaction of Mutants with Rhodopsin Kinase and Arrestin

1995 • 98 citations

A proline-rich region of the third intracellular loop imparts phenotypic beta 1-versus beta 2-adrenergic receptor coupling and sequestration

1994 • 98 citations

Recovery of beta-adrenergic receptors following long term exposure of astrocytoma cells to catecholamine. Role of protein synthesis.

1981 • 96 citations

Binding of wild type and chimeric arrestins to the m2 muscarinic cholinergic receptor

1993 • 96 citations

A splice variant of arrestin. Molecular cloning and localization in bovine retina.

1994 • 96 citations

Molecular cloning of the S-antigen cDNA from bovine retina

1987 • 94 citations

Chronic Morphine Administration Increases β‐Adrenergic Receptor Kinase (βARK) Levels in the Rat Locus Coeruleus

1994 • 94 citations

Characterization of a truncated form of arrestin isolated from bovine rod outer segments

1994 • 92 citations

Sequestration of the short and long isoforms of dopamine D2 receptors expressed in Chinese hamster ovary cells.

1996 • 90 citations

Agonist-dependent Phosphorylation and Desensitization of the Rat A3 Adenosine Receptor

1995 • 90 citations

Members of the G Protein-Coupled Receptor Kinase Family That Phosphorylate the β₂-Adrenergic Receptor Facilitate Sequestration

1996 • 88 citations

New Molecular and Structural Determinants Involved in β2-Adrenergic Receptor Desensitization and Sequestration

1996 • 87 citations

Structure and functions of arrestins

1994 • 86 citations

Direct Observation of Endocytosis of Gastrin Releasing Peptide and Its Receptor

1995 • 85 citations

Visual arrestin binding to rhodopsin. Intramolecular interaction between the basic N terminus and acidic C terminus of arrestin may regulate binding selectivity.

1994 • 85 citations

The arrestin superfamily: cone arrestins are a fourth family

1995 • 82 citations

Intracellular trafficking of the muscarinic acetylcholine receptor: importance of subtype and cell type.

1996 • 77 citations

The conserved NPXnY motif present in the gastrin-releasing peptide receptor is not a general sequestration sequence.

1994 • 73 citations

Separation of the structural requirements for agonist-promoted activation and sequestration of the beta-adrenergic receptor.

1990 • 64 citations

Location of agonist‐dependent‐phosphorylation sites in the third intracellular loop of muscarinic acetylcholine receptors (m2 subtype)

1994 • 61 citations

Structural organization of the human S-antigen gene. cDNA, amino acid, intron, exon, promoter, in vitro transcription, retina, and pineal gland.

1990 • 60 citations

Differential internalisation of mGluR1 splice variants in response to agonist and phorbol esters in permanently transfected BHK cells

1997 • 56 citations

A truncation mutation in the avian beta-adrenergic receptor causes agonist-induced internalization and GTP-sensitive agonist binding characteristic of mammalian receptors.

1990 • 50 citations

Overlapping multi-site domains of the muscarinic cholinergic Hm1 receptor involved in signal transduction and sequestration.

1994 • 48 citations

Molecular Cloning, Functional Expression and mRNA Analysis of Human Beta-Adrenergic Receptor Kinase 2

1993 • 36 citations

Deletion analysis of the m4 muscarinic acetylcholine receptor

1994 • 35 citations

Carboxyl-terminal Domains in the Avian β1-Adrenergic Receptor That Regulate Agonist-promoted Endocytosis

1995 • 31 citations

Interaction of the COOH-terminal domain of the neurotensin receptor with a G protein does not control the phospholipase C activation but is involved in the agonist-induced internalization.

1996 • 31 citations

Identification of a Region Required for Subtype-specific Agonist-induced Sequestration of the m2 Muscarinic Acetylcholine Receptor

1996 • 30 citations

A Segment Corresponding to Amino Acids Val170-Arg182 of Bovine Arrestin is Capable of Binding to Phosphorylated Rhodopsin

1994 • 30 citations

Protein kinase C-mediated phosphorylation of retinal rod outer segment membrane proteins

1989 • 27 citations

Carboxyl-terminal Domains Determine Internalization and Recycling Characteristics of Bombesin Receptor Chimeras

1995 • 23 citations

Influence of Second and Third Cytoplasmic Loops on Binding, Internalization, and Coupling of Chimeric Bombesin/m3 Muscarinic Receptors

1995 • 18 citations

Evidence for ATP‐ase activity of arrestin from bovine photoreceptors

1991 • 8 citations

Deleted Work

1955 • 0 citations