A proline-rich region of the third intracellular loop imparts phenotypic beta 1-versus beta 2-adrenergic receptor coupling and sequestration

Measurement of protein using bicinchoninic acid

1985 • 17,516 citations

A highly sensitive adenylate cyclase assay

1974 • 4,213 citations

A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor.

1980 • 1,579 citations

Multiple dopamine D4 receptor variants in the human population

1992 • 967 citations

[71] Use of eukaryotic expression technology in the functional analysis of cloned genes

1987 • 834 citations

A quantitative analysis of beta-adrenergic receptor interactions: resolution of high and low affinity states of the receptor by computer modeling of ligand binding data.

1980 • 545 citations

A hypervariable segment in the human dopamine receptor D₄ (DRD4) gene

1993 • 536 citations

A polymorphism of the human beta 2-adrenergic receptor within the fourth transmembrane domain alters ligand binding and functional properties of the receptor.

1993 • 470 citations

Beta-adrenergic receptor sequestration. A potential mechanism of receptor resensitization.

1993 • 387 citations

Mutations that uncouple the beta-adrenergic receptor from Gs and increase agonist affinity.

1987 • 259 citations

Structural basis for receptor subtype-specific regulation revealed by a chimeric beta 3/beta 2-adrenergic receptor.

1993 • 227 citations

A small region of the beta-adrenergic receptor is selectively involved in its rapid regulation.

1991 • 166 citations

Structural basis of beta-adrenergic receptor subtype specificity studied with chimeric beta 1/beta 2-adrenergic receptors.

1988 • 160 citations

Coupling of a mutated form of the human beta 2-adrenergic receptor to Gi and Gs. Requirement for multiple cytoplasmic domains in the coupling process.

1991 • 131 citations

Subtype-selective desensitization of alpha 2-adrenergic receptors. Different mechanisms control short and long term agonist-promoted desensitization of alpha 2C10, alpha 2C4, and alpha 2C2.

1992 • 131 citations

Beta 1- and beta 2-adrenergic receptors display subtype-selective coupling to Gs.

1992 • 117 citations

Distinct regulation of beta 1- and beta 2-adrenergic receptors in Chinese hamster fibroblasts.

1992 • 106 citations

Specific activation of G_s by synthetic peptides corresponding to an intracellular loop of the β‐adrenergic receptor

1991 • 105 citations

Efficacy of beta 1-adrenergic receptors is lower than that of beta 2-adrenergic receptors.

1993 • 101 citations

Altered patterns of agonist-stimulated cAMP accumulation in cells expressing mutant beta 2-adrenergic receptors lacking phosphorylation sites.

1989 • 70 citations

Regulation of cellular signal transduction pathways by desensitization and amplification

1994 • 62 citations