Identification, purification, and characterization of GRK5, a member of the family of G protein-coupled receptor kinases.

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

A comprehensive set of sequence analysis programs for the VAX

1984 • 14,824 citations

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

Turning off the signal: desensitization of β‐adrenergic receptor function

1990 • 1,241 citations

β-Arrestin: a Protein that Regulates β-adrenergic Receptor Function

1990 • 1,162 citations

Phosphodiesterase activation by photoexcited rhodopsin is quenched when rhodopsin is phosphorylated and binds the intrinsic 48-kDa protein of rod outer segments.

1986 • 781 citations

Role of βγ Subunits of G Proteins in Targeting the β-Adrenergic Receptor Kinase to Membrane-Bound Receptors

1992 • 703 citations

Beta-adrenergic receptor kinase: identification of a novel protein kinase that phosphorylates the agonist-occupied form of the receptor.

1986 • 650 citations

The binding site for the beta gamma subunits of heterotrimeric G proteins on the beta-adrenergic receptor kinase.

1993 • 467 citations

β-Adrenergic Receptor Kinase: Primary Structure Delineates a Multigene Family

1989 • 451 citations

G protein—coupled receptor kinases

1993 • 434 citations

Phosphorylation Sites on Two Domains of the β2-Adrenergic Receptor Are Involved in Distinct Pathways of Receptor Desensitization

1989 • 415 citations

Isoprenylation in regulation of signal transduction by G-protein-coupled receptor kinases

1992 • 306 citations

Mechanism of rhodopsin kinase activation

1991 • 301 citations

Light-dependent phosphorylation of rhodopsin. Purification and properties of rhodopsin kinase.

1978 • 291 citations

[2] Chemical properties and separation of phosphoamino acids by thin-layer chromatography and/or electrophoresis

1991 • 246 citations

Purification and characterization of the beta-adrenergic receptor kinase.

1987 • 241 citations

Role of acidic amino acids in peptide substrates of the .beta.-adrenergic receptor kinase and rhodopsin kinase

1991 • 220 citations

Cloning, expression, and chromosomal localization of beta-adrenergic receptor kinase 2. A new member of the receptor kinase family

1991 • 214 citations

Light-dependent phosphorylation of rhodopsin by β-adrenergic receptor kinase

1986 • 205 citations

Sequential phosphorylation of rhodopsin at multiple sites

1993 • 204 citations

β-Adrenergic Receptor Kinase-2 and β-Arrestin-2 as Mediators of Odorant-Induced Desensitization

1993 • 201 citations

The multiple membrane spanning topography of the beta 2-adrenergic receptor. Localization of the sites of binding, glycosylation, and regulatory phosphorylation by limited proteolysis.

1987 • 199 citations

The G-protein-coupled receptor kinases beta ARK1 and beta ARK2 are widely distributed at synapses in rat brain

1992 • 197 citations

Isoprenylation of a protein kinase. Requirement of farnesylation/alpha-carboxyl methylation for full enzymatic activity of rhodopsin kinase.

1992 • 196 citations

The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase.

1991 • 189 citations

The substance P receptor, which couples to Gq/11, is a substrate of beta-adrenergic receptor kinase 1 and 2

1993 • 178 citations

Cloning and expression of GRK5: a member of the G protein-coupled receptor kinase family.

1993 • 159 citations

Agonist-dependent phosphorylation of the alpha 2-adrenergic receptor by the beta-adrenergic receptor kinase.

1987 • 156 citations

The influence of arrestin (48K protein) and rhodopsin kinase on visual transduction

1992 • 151 citations

Purification and characterization of rhodopsin kinase.

1988 • 149 citations

A beta-adrenergic receptor kinase-like enzyme is involved in olfactory signal termination.

1993 • 146 citations

Molecular cloning and expression of GRK6. A new member of the G protein-coupled receptor kinase family.

1993 • 139 citations

G protein .beta..gamma. subunits from bovine brain and retina: equivalent catalytic support of ADP-ribosylation of .alpha. subunits by pertussis toxin but differential interactions with Gs.alpha.

1989 • 139 citations

Beta-adrenergic receptor kinase. Agonist-dependent receptor binding promotes kinase activation.

1993 • 127 citations

Regulation of rhodopsin kinase by autophosphorylation.

1991 • 120 citations

Inhibition of beta-adrenergic receptor kinase prevents rapid homologous desensitization of beta 2-adrenergic receptors.

1989 • 117 citations

Isolation of Drosophila genes encoding G protein-coupled receptor kinases.

1991 • 100 citations

A novel G protein-coupled receptor kinase gene cloned from 4p16.3

1992 • 99 citations

Phosphorylation and desensitization of human m2 muscarinic cholinergic receptors by two isoforms of the beta-adrenergic receptor kinase

1993 • 96 citations

Activation by G protein beta gamma subunits of beta-adrenergic and muscarinic receptor kinase.

1993 • 83 citations

Inhibition of the β-Adrenergic Receptor Kinase by Polyanions

1989 • 83 citations

Substrate recognition determinants for rhodopsin kinase: studies with synthetic peptides, polyanions, and polycations

1989 • 80 citations

Identification of the autophosphorylation sites in rhodopsin kinase.

1992 • 72 citations

Characterization of rhodopsin kinase purified from bovine rod outer segments.

1990 • 71 citations

Identification of additional members of human G-protein-coupled receptor kinase multigene family.

1993 • 55 citations

Purification and functional characterization of β‐adrenergic receptor kinase expressed in insect cells

1993 • 27 citations