Constitutive Activation of Opsin: Interaction of Mutants with Rhodopsin Kinase and Arrestin

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Protein Purification by Affinity Chromatography

1970 • 2,809 citations

MODEL SYSTEMS FOR THE STUDY OF SEVEN-TRANSMEMBRANE-SEGMENT RECEPTORS

1991 • 1,357 citations

Molecular Basis of Visual Excitation

1968 • 1,002 citations

Phosphodiesterase activation by photoexcited rhodopsin is quenched when rhodopsin is phosphorylated and binds the intrinsic 48-kDa protein of rod outer segments.

1986 • 781 citations

Glutamic acid-113 serves as the retinylidene Schiff base counterion in bovine rhodopsin.

1989 • 663 citations

Tautomeric Forms of Metarhodopsin

1963 • 602 citations

Constitutively active mutants of rhodopsin

1992 • 513 citations

Functional heterogeneity of mutant rhodopsins responsible for autosomal dominant retinitis pigmentosa.

1991 • 492 citations

Structure and mechanism of the G protein-coupled receptor kinases.

1993 • 480 citations

Effect of Carboxylic Acid Side Chains on the Absorption Maximum of Visual Pigments

1989 • 469 citations

Expression of a synthetic bovine rhodopsin gene in monkey kidney cells.

1987 • 444 citations

Rhodopsin, photoreceptor of the rod cell. An emerging pattern for structure and function.

1992 • 439 citations

Rhodopsin mutation G90D and a molecular mechanism for congenital night blindness

1994 • 373 citations

Rhodopsin and phototransduction: a model system for G protein‐linked receptors

1992 • 332 citations

Heterozygous missense mutation in the rhodopsin gene as a cause of congenital stationary night blindness

1993 • 323 citations

Determinants of visual pigment absorbance: identification of the retinylidene Schiff's base counterion in bovine rhodopsin

1990 • 319 citations

Characterization of bovine rod outer segment G-protein.

1982 • 281 citations

Complex formation between metarhodopsin II and GTP‐binding protein in bovine protoreceptor membranes leads to a shift of the photoproduct equilibrium

1982 • 259 citations

Defective intracellular transport is the molecular basis of rhodopsin-dependent dominant retinal degeneration.

1995 • 239 citations

G-protein-coupled receptor kinases

1991 • 219 citations

Constitutive activation of opsin: Influence of charge at position 134 and size at position 296

1993 • 218 citations

Localization of binding sites for carboxyl terminal specific anti-rhodopsin monoclonal antibodies using synthetic peptides

1984 • 204 citations

Isoprenylation of a protein kinase. Requirement of farnesylation/alpha-carboxyl methylation for full enzymatic activity of rhodopsin kinase.

1992 • 196 citations

The receptor kinase family: primary structure of rhodopsin kinase reveals similarities to the beta-adrenergic receptor kinase.

1991 • 189 citations

Inactivation of photoexcited rhodopsin in retinal rods: the roles of rhodopsin kinase and 48-kDa protein (arrestin)

1988 • 185 citations

Total synthesis of a gene for bovine rhodopsin.

1986 • 179 citations

Rhodopsin Phosphorylation and Dephosphorylation in Vivo

1995 • 176 citations

Chapter 5 Interactions between photoexcited rhodopsin and light-activated enzymes in rods

1984 • 174 citations

Mechanism of activation and inactivation of opsin: role of Glu113 and Lys296

1992 • 169 citations

Autosomal dominant retinitis pigmentosa: Four new mutations in rhodopsin, one of them in the retinal attachment site

1991 • 166 citations

Dark-light: model for nightblindness from the human rhodopsin Gly-90-->Asp mutation.

1995 • 149 citations

Retinal degeneration caused by dominant rhodopsin mutations in Drosophila

1995 • 135 citations

Amplification of phosphodiesterase activation is greatly reduced by rhodopsin phosphorylation

1986 • 130 citations

A constitutively active mutant beta 2-adrenergic receptor is constitutively desensitized and phosphorylated.

1994 • 129 citations

Constitutive activation of phototransduction by K296E opsin is not a cause of photoreceptor degeneration.

1995 • 128 citations

Transducin Activation by Rhodopsin Without a Covalent Bond to the 11- Cis -Retinal Chromophore

1991 • 114 citations

The ligand-binding domain of rhodopsin and other G protein-linked receptors

1992 • 107 citations

Opsins with mutations at the site of chromophore attachment constitutively activate transducin but are not phosphorylated by rhodopsin kinase.

1994 • 48 citations

Does protein kinase C play a role in rhodopsin desensitization?

1993 • 27 citations