The conserved NPXnY motif present in the gastrin-releasing peptide receptor is not a general sequestration sequence.

Inositol phosphates and cell signalling

1989 • 4,058 citations

MODEL SYSTEMS FOR THE STUDY OF SEVEN-TRANSMEMBRANE-SEGMENT RECEPTORS

1991 • 1,357 citations

NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor.

1990 • 944 citations

Bombesin stimulation of DNA synthesis and cell division in cultures of Swiss 3T3 cells.

1983 • 470 citations

Ligand-regulated internalization and recycling of human beta 2-adrenergic receptors between the plasma membrane and endosomes containing transferrin receptors.

1992 • 445 citations

Removal of phosphorylation sites from the β2-adrenergic receptor delays onset of agonist-promoted desensitization

1988 • 429 citations

A highly conserved tyrosine residue in G protein-coupled receptors is required for agonist-mediated beta 2-adrenergic receptor sequestration.

1994 • 361 citations

The neuronal origin of bombesin-like immunoreactivity in the rat gastrointestinal tract

1979 • 325 citations

G-protein-coupled receptor kinases

1991 • 219 citations

A small region of the beta-adrenergic receptor is selectively involved in its rapid regulation.

1991 • 166 citations

Receptor-mediated internalization of insulin requires a 12-amino acid sequence in the juxtamembrane region of the insulin receptor beta-subunit.

1990 • 130 citations

Bradykinin and bombesin rapidly stimulate tyrosine phosphorylation of a 120-kDa group of proteins in Swiss 3T3 cells.

1991 • 117 citations

Immunocytochemical identification of islet cells and nerve fibers containing calcitonin gene-related peptide-like immunoreactivity in the rat pancreas

1986 • 112 citations

Serines and threonines in the gastrin-releasing peptide receptor carboxyl terminus mediate internalization.

1993 • 105 citations

A domain of the insulin receptor required for endocytosis in rat fibroblasts.

1990 • 97 citations

Stimulation of tyrosine kinase activity in anti-phosphotyrosine immune complexes of Swiss 3T3 cell lysates occurs rapidly after addition of bombesin, vasopressin, and endothelin to intact cells.

1991 • 84 citations

Central Nervous System Inhibition of Gastric Secretion in the Rat by GastrinReleasing Peptide, a Mammalian Bombesin

1981 • 82 citations

Chronic desensitization to bombesin by progressive down-regulation of bombesin receptors in Swiss 3T3 cells. Distinction from acute desensitization.

1990 • 69 citations

A truncation mutation in the avian beta-adrenergic receptor causes agonist-induced internalization and GTP-sensitive agonist binding characteristic of mammalian receptors.

1990 • 50 citations

Internalization and degradation of peptides of the bombesin family in Swiss 3T3 cells occurs without ligand-induced receptor down-regulation.

1987 • 50 citations

Characterization of the high-affinity receptors on Swiss 3T3 cells which mediate the binding, internalization and degradation of the mitogenic peptide bombesin

1988 • 28 citations

Bombesin microinjected into the dorsal vagal complex inhibits TRH-stimulated gastric contractility in rats

1990 • 15 citations

Comparison of the Actions of Bombesin, Gastrin-Releasing Peptide-27, Neuromedin B, and Gastrin-Releasing Peptide-10 in Causing Release of Gastrin and Gastric Inhibitory Peptide in Rats

1986 • 13 citations