HLA-DM and invariant chain are expressed by thyroid follicular cells, enabling the expression of compact DR molecules

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

ROLE OF ABERRANT HLA-DR EXPRESSION AND ANTIGEN PRESENTATION IN INDUCTION OF ENDOCRINE AUTOIMMUNITY

1983 • 1,275 citations

ABERRANT EXPRESSION OF HLA-DR ANTIGEN ON THYROCYTES IN GRAVES' DISEASE: RELEVANCE FOR AUTOIMMUNITY

1983 • 710 citations

HLA-DM induces clip dissociation from MHC class II αβ dimers and facilitates peptide loading

1995 • 684 citations

Autoimmune Thyroid Disease: Further Developments in Our Understanding*

1994 • 611 citations

The structure of an intermediate in class II MHC maturation: CLIP bound to HLA-DR3

1995 • 583 citations

Mediation by HLA-DM of dissociation of peptides from HLA-DR

1995 • 555 citations

Intracellular transport of class II MHC molecules directed by invariant chain

1990 • 548 citations

Epithelial cells expressing aberrant MHC class II determinants can present antigen to cloned human T cells

1984 • 432 citations

HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides

1992 • 380 citations

Human T-Cell Clones from Autoimmune Thyroid Glands: Specific Recognition of Autologous Thyroid Cells

1985 • 326 citations

Article

1995 • 325 citations

Antigen presentation mediated by recycling of surface HLA-DR molecules

1995 • 271 citations

Antigen Presentation and T Cell Development in H2-M-Deficient Mice

1996 • 263 citations

Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells

1994 • 247 citations

HLA-DMA and DMB genes are both required for MHC class II/peptide complex formation in antigen-presenting cells

1994 • 247 citations

Immunological functions of non-professional antigen-presenting cells: new insights from studies of T-cell interactions with keratinocytes

1994 • 246 citations

Negative Regulation by HLA-DO of MHC Class II-Restricted Antigen Processing

1997 • 234 citations

Lectin-induced expression of DR antigen on human cultured follicular thyroid cells

1983 • 233 citations

HLA-DM Interactions with Intermediates in HLA-DR Maturation and a Role for HLA-DM in Stabilizing Empty HLA-DR Molecules

1996 • 206 citations

A lysosomal targeting signal in the cytoplasmic tail of the beta chain directs HLA-DM to MHC class II compartments.

1995 • 198 citations

An endogenous processing pathway in vaccinia virus-infected cells for presentation of cytoplasmic antigens to class II-restricted T cells.

1990 • 188 citations

Binding of major histocompatibility complex class II to the invariant chain-derived peptide, CLIP, is regulated by allelic polymorphism in class II.

1995 • 186 citations

Differential expression and serologically distinct subpopulations of human Ia antigens detected with monoclonal antibodies to Ia alpha and beta chains

1982 • 183 citations

Irreversible association of peptides with class II MHC molecules in living cells

1992 • 173 citations

HLA-DO is a lysosomal resident which requires association with HLA-DM for efficient intracellular transport.

1996 • 161 citations

Autoantigen recognition by thyroid-infiltrating T cells in Graves disease.

1991 • 148 citations

How HLA-DM edits the MHC class II peptide repertoire: survival of the fittest?

1997 • 127 citations

HLA-DM Is Localized to Conventional and Unconventional MHC Class II–Containing Endocytic Compartments

1996 • 122 citations

A human Ia cytoplasmic determinant located on multiple forms of invariant chain (gamma, gamma 2, gamma 3).

1984 • 119 citations

Single‐cell analysis of intrathyroidal lymphocytes shows differential cytokine expression in Hashimoto's and Graves' disease

1997 • 115 citations

The requirement for DM in class II-restricted antigen presentation and SDS-stable dimer formation is allele and species dependent.

1995 • 112 citations

Kinetic analysis of peptide loading onto HLA-DR molecules mediated by HLA-DM.

1996 • 106 citations

Heterogeneity in antigen processing by different types of antigen-presenting cells. Effect of cell culture on antigen processing ability.

1992 • 85 citations

Thyroid antibodies are produced by thyroid-derived lymphocytes.

1982 • 84 citations

Antigen presentation by interferon‐γ‐treated thyroid follicular cells inhibits interleukin‐2 (IL‐2) and supports IL‐4 production by B7‐dependent human T cells

1997 • 70 citations

Human self-reactive T cell clones expressing identical T cell receptor beta chains differ in their ability to recognize a cryptic self-epitope.

1996 • 67 citations

Occurrence of Thyrocyte HLA Class II Expression in a Wide Variety of Thyroid Diseases: Relationship With Lymphocytic Infiltration and Thyroid Autoantibodies

1988 • 63 citations

Biological and biochemical characterization of an SV40-transformed xeroderma pigmentosum cell line

1984 • 49 citations

Expression of the costimulatory molecule B7/BB1 in autoimmune thyroid disease

1994 • 43 citations

The invariant chain inhibits presentation of endogenous antigens by a human fibroblast cell line

1994 • 37 citations

Self-reactive cytotoxic gamma delta T lymphocytes in Graves' disease specifically recognize thyroid epithelial cells.

1996 • 29 citations

Deletion of a C-terminal sequence of the class II-associated invariant chain abrogates invariant chains oligomer formation and class II antigen presentation.

1995 • 27 citations

Proteasome subunits, low‐molecular‐mass polypeptides 2 and 7 are hyperexpressed by target cells in autoimmune thyroid disease but not in insulin‐dependent diabetes mellitus: implications for autoimmunity

1997 • 20 citations

Hyperexpression of transporter in antigen processing-1 (TAP-1) in thyroid glands affected by autoimmunity: a contributory factor to the breach of tolerance to thyroid antigens?

1997 • 16 citations

Selective processing of exogenous antigens by antigen-presenting cells with deleted MHC genes.

1995 • 13 citations

One Monoclonal Antibody to Human Thyrotropin (TSH) Receptor Agonist of TSH Hormone Stimulates the Proliferation of Human Thyroid Cells

1995 • 9 citations

Antibodies specific for human thyrotropin receptor induce MHC antigen expression in thyroid cells.

1994 • 7 citations

Class II Antigen Processing Compartments and the Function of HLA-DM

1996 • 5 citations

Proteasome subunits LMP2 and LMP7 are hyperexpressed by target cells in autoimmune thyroid disease (AITD) but not in insulin dependent diabetes mellitus (IDDM)

1997 • 2 citations