Mediation by HLA-DM of dissociation of peptides from HLA-DR

Dominance and Crypticity of T Cell Antigenic Determinants

1993 • 838 citations

Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments

1991 • 663 citations

Isolation and characterization of antigen-la complexes involved in T cell recognition

1986 • 470 citations

Transient accumulation of new class II MHC molecules in a novel endocytic compartment in B lymphocytes

1994 • 442 citations

Characterization and use of theDrosophilametallothionein promoter in culturedDrosophila melanogastercells

1988 • 440 citations

Isolation and characterization of the intracellular MHC class II compartment

1994 • 426 citations

HLA-DR molecules from an antigen-processing mutant cell line are associated with invariant chain peptides

1992 • 380 citations

An essential role for HLA–DM in antigen presentation by class II major histocompatibility molecules

1994 • 378 citations

Antigen processing and class II MHC peptide-loading compartments in human B-lymphoblastoid cells

1994 • 349 citations

The human class II MHC protein HLA-DR1 assembles as empty αβ heterodimers in the absence of antigenic peptide

1992 • 306 citations

A transposable P vector that confers selectable G418 resistance to Drosophila larvae

1985 • 286 citations

A new human HLA class II-related locus, DM

1991 • 251 citations

Assembly and intracellular transport of HLA-DM and correction of the class II antigen-processing defect in T2 cells

1994 • 247 citations

HLA-DMA and DMB genes are both required for MHC class II/peptide complex formation in antigen-presenting cells

1994 • 247 citations

Accumulation of HLA-DM, a regulator of antigen presentation, in MHC class II compartments

1994 • 244 citations

Defective processing and presentation of exogenous antigens in mutants with normal HLA class II genes

1990 • 236 citations

Separation of subcellular compartments containing distinct functional forms of MHC class II.

1994 • 221 citations

Invariant Chain Peptides in Most HLA-DR Molecules of an Antigen-Processing Mutant

1992 • 218 citations

Peptides determine the lifespan of MHC class II molecules in the antigen-presenting cell

1994 • 175 citations

Irreversible association of peptides with class II MHC molecules in living cells

1992 • 173 citations

Monoclonal antibodies specific for the carboxy terminus of simian virus 40 large T antigen

1984 • 163 citations

Peptide binding inhibits protein aggregation of invariant-chain free class II dimers and promotes surface expression of occupied molecules

1993 • 157 citations

Reconstitution of an operational MHC class II compartment in nonantigen-presenting cells

1994 • 135 citations

The antigen-processing mutant T2 suggests a role for MHC-linked genes in class II antigen presentation.

1992 • 125 citations

A gene required for class II-restricted antigen presentation maps to the major histocompatibility complex.

1991 • 106 citations

Identification of two distinct properties of class II major histocompatibility complex-associated peptides.

1993 • 101 citations

A mutant human histocompatibility leukocyte antigen DR molecule associated with invariant chain peptides.

1994 • 91 citations

MHC class II deletion mutant expresses normal levels of transgene encoded class II molecules that have abnormal conformation and impaired antigen presentation ability.

1992 • 72 citations

Invariant-cognate peptide exchange restores class II dimer stability in HLA-DM mutants.

1994 • 47 citations