Irreversible association of peptides with class II MHC molecules in living cells

Protein and cell membrane iodinations with a sparingly soluble chloroamide, 1,3,4,6-tetrachloro-3a,6a-diphenylglycoluril

1978 • 4,673 citations

Antigen-specific interaction between T and B cells

1985 • 1,396 citations

Peptide-binding specificity of the molecular chaperone BiP

1991 • 763 citations

Universally immunogenic T cell epitopes: promiscuous binding to human MHC class II and promiscuous recognition by T cells

1989 • 706 citations

Segregation of MHC class II molecules from MHC class I molecules in the Golgi complex for transport to lysosomal compartments

1991 • 663 citations

Invariant chain association with HLA-DR molecules inhibits immunogenic peptide binding

1990 • 486 citations

The biosynthetic pathway of MHC class II but not class I molecules intersects the endocytic route

1990 • 445 citations

MHC class II structure, occupancy and surface expression determined by post-endoplasmic reticulum antigen binding

1991 • 394 citations

Magnitude of response of histocompatibility-restricted T-cell clones is a function of the product of the concentrations of antigen and Ia molecules.

1983 • 312 citations

The human class II MHC protein HLA-DR1 assembles as empty αβ heterodimers in the absence of antigenic peptide

1992 • 306 citations

Invariant chain distinguishes between the exogenous and endogenous antigen presentation pathways

1990 • 303 citations

Interactions between Immunogenic Peptides and MHC Proteins

1991 • 303 citations

A role for peptide in determining MHC class II structure

1991 • 275 citations

Cycling of cell-surface MHC glycoproteins through primaquine-sensitive intracellular compartments

1990 • 254 citations

Inhibition of endosomal proteolytic activity by leupeptin blocks surface expression of MHC class II molecules and their conversion to SDS resistance alpha beta heterodimers in endosomes.

1992 • 219 citations

Antigen processing by epidermal Langerhans cells correlates with the level of biosynthesis of major histocompatibility complex class II molecules and expression of invariant chain.

1990 • 214 citations

A hypothetical model for the peptide binding domain of hsp70 based on the peptide binding domain of HLA.

1991 • 191 citations

Processed antigen binds to newly synthesized mhc class II molecules in antigen-specific B lymphocytes

1991 • 188 citations

Differential expression and serologically distinct subpopulations of human Ia antigens detected with monoclonal antibodies to Ia alpha and beta chains

1982 • 183 citations

Epitope-directed processing of specific antigen by B lymphocytes.

1989 • 163 citations

Class II major histocompatibility complex molecules of murine dendritic cells: synthesis, sialylation of invariant chain, and antigen processing capacity are down-regulated upon culture.

1991 • 158 citations

High-affinity binding of an influenza hemagglutinin-derived peptide to purified HLA-DR.

1990 • 148 citations

Antigen Uptake and Accumulation in Antigen‐Specific B Cells

1987 • 148 citations

Regulation of antigen presentation by acidic pH.

1990 • 127 citations

Degenerate binding of immunogenic peptides to HLA-DR proteins on B cell Srfaces

1990 • 122 citations

Antigen processing and intracellular Ia. Possible roles of endocytosis and protein synthesis in Ia function.

1989 • 122 citations

Internalization of lymphocyte membrane components

1985 • 94 citations

Competition for antigen presentation in living cells involves exchange of peptides bound by class II MHC molecules

1989 • 94 citations

Selective radiolabeling of cell surface proteins to a high specific activity

1987 • 92 citations

Evolution of the major histocompatibility complex: molecular cloning of major histocompatibility complex class I from the amphibian Xenopus.

1991 • 89 citations

Turnover of Ia-peptide complexes is facilitated in viable antigen-presenting cells: biosynthetic turnover of Ia vs. peptide exchange.

1989 • 87 citations

A new method for detecting endocytosed proteins.

1988 • 79 citations

Inhibition by brefeldin A of presentation of exogenous protein antigens to MHC class II-restricted T cells

1990 • 74 citations

Recognition by Class II Alloreactive T Cells of Processed Determinants from Human Serum Proteins

1991 • 72 citations

Lack of detectable endocytosis of B lymphocyte MHC class II antigens using an antibody-independent technique.

1990 • 66 citations

MHC class II-restricted presentation of native protein antigen by B cells is inhibitable by cycloheximide and brefeldin A.

1990 • 61 citations

Free ligand-induced dissociation of MHC-antigen complexes.

1991 • 39 citations

On the dissociation and reassociation of MHC class II-foreign peptide complexes. Evidence that brief transit through an acidic compartment is not sufficient for binding site regeneration.

1990 • 25 citations

Stable association of processed antigen with antigen-presenting cell membranes.

1989 • 19 citations

Antibody recognition of an immunogenic influenza hemagglutinin-human leukocyte antigen class II complex.

1991 • 11 citations