Endoplasmic Reticulum Stress and the Development of Diabetes

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Protein folding in the cell

1992 • 4,138 citations

XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor

2001 • 3,799 citations

Caspase-12 mediates endoplasmic-reticulum-specific apoptosis and cytotoxicity by amyloid-β

2000 • 3,241 citations

Protein translation and folding are coupled by an endoplasmic-reticulum-resident kinase

1999 • 3,119 citations

Regulated Translation Initiation Controls Stress-Induced Gene Expression in Mammalian Cells

2000 • 3,071 citations

Coupling of Stress in the ER to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1

2000 • 2,831 citations

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

2002 • 2,702 citations

Dynamic interaction of BiP and ER stress transducers in the unfolded-protein response

2000 • 2,696 citations

CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum

1998 • 1,972 citations

Mammalian Transcription Factor ATF6 Is Synthesized as a Transmembrane Protein and Activated by Proteolysis in Response to Endoplasmic Reticulum Stress

1999 • 1,954 citations

Functional and Genomic Analyses Reveal an Essential Coordination between the Unfolded Protein Response and ER-Associated Degradation

2000 • 1,939 citations

Perk Is Essential for Translational Regulation and Cell Survival during the Unfolded Protein Response

2000 • 1,933 citations

Gadd153 Sensitizes Cells to Endoplasmic Reticulum Stress by Down-Regulating Bcl2 and Perturbing the Cellular Redox State

2001 • 1,840 citations

Translational control of gene expression

2000 • 1,371 citations

Translational Control Is Required for the Unfolded Protein Response and In Vivo Glucose Homeostasis

2001 • 1,329 citations

Oligomerization and phosphorylation of the Ire1p kinase during intracellular signaling from the endoplasmic reticulum to the nucleus.

1996 • 1,306 citations

Feedback Inhibition of the Unfolded Protein Response by GADD34-Mediated Dephosphorylation of eIF2α

2001 • 1,283 citations

Plasma cell differentiation requires the transcription factor XBP-1

2001 • 1,256 citations

Diabetes Mellitus and Exocrine Pancreatic Dysfunction in Perk−/− Mice Reveals a Role for Translational Control in Secretory Cell Survival

2001 • 1,204 citations

Setting the Standards: Quality Control in the Secretory Pathway

1999 • 1,198 citations

Transcriptional induction of genes encoding endoplasmic reticulum resident proteins requires a transmembrane protein kinase

1993 • 1,197 citations

Cross-Talk between Two Cysteine Protease Families

2000 • 1,158 citations

A Novel Mechanism for Regulating Activity of a Transcription Factor That Controls the Unfolded Protein Response

1996 • 1,017 citations

The glucose-regulated proteins: stress induction and clinical applications

2001 • 1,013 citations

ATF6 Activated by Proteolysis Binds in the Presence of NF-Y (CBF) Directly to thecis-Acting Element Responsible for the Mammalian Unfolded Protein Response

2000 • 921 citations

Stress-Induced Phosphorylation and Activation of the Transcription Factor CHOP (GADD153) by p38 MAP Kinase

1996 • 893 citations

A stress response pathway from the endoplasmic reticulum to the nucleus requires a novel bifunctional protein kinase/endoribonuclease (Ire1p) in mammalian cells

1998 • 888 citations

The Transmembrane Kinase Ire1p Is a Site-Specific Endonuclease That Initiates mRNA Splicing in the Unfolded Protein Response

1997 • 886 citations

Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetes

2002 • 858 citations

Activation of Caspase-12, an Endoplastic Reticulum (ER) Resident Caspase, through Tumor Necrosis Factor Receptor-associated Factor 2-dependent Mechanism in Response to the ER Stress

2001 • 832 citations

A transmembrane protein with a cdc2+CDC28-related kinase activity is required for signaling from the ER to the nucleus

1993 • 814 citations

EIF2AK3, encoding translation initiation factor 2-α kinase 3, is mutated in patients with Wolcott-Rallison syndrome

2000 • 800 citations

Cloning of mammalian Ire1 reveals diversity in the ER stress responses

1998 • 782 citations

Identification and Characterization of Pancreatic Eukaryotic Initiation Factor 2 α-Subunit Kinase, PEK, Involved in Translational Control

1998 • 763 citations

Transcriptional Profiling Shows that Gcn4p Is a Master Regulator of Gene Expression during Amino Acid Starvation in Yeast

2001 • 739 citations

Targeted disruption of the Chop gene delays endoplasmic reticulum stress–mediated diabetes

2002 • 724 citations

Complementary Signaling Pathways Regulate the Unfolded Protein Response and Are Required for C. elegans Development

2001 • 693 citations

Signals from the Stressed Endoplasmic Reticulum Induce C/EBP-Homologous Protein (CHOP/GADD153)

1996 • 671 citations

Nitric oxide-induced apoptosis in pancreatic β cells is mediated by the endoplasmic reticulum stress pathway

2001 • 594 citations

Coupling Endoplasmic Reticulum Stress to the Cell Death Program

2001 • 584 citations

A mutation in the insulin 2 gene induces diabetes with severe pancreatic β-cell dysfunction in the Mody mouse

1999 • 555 citations

Activation of ATF6 and an ATF6 DNA binding site by the endoplasmic reticulum stress response.

2000 • 551 citations

A gene encoding a transmembrane protein is mutated in patients with diabetes mellitus and optic atrophy (Wolfram syndrome)

2000 • 525 citations

Activation of ATF6 and an ATF6 DNA Binding Site by the Endoplasmic Reticulum Stress Response

2000 • 485 citations

Diabetes insipidus, diabetes mellitus, optic atrophy and deafness (DIDMOAD) caused by mutations in a novel gene (wolframin) coding for a predicted transmembrane protein

1998 • 467 citations

Mammalian stress response: induction of the glucose-regulated protein family

1992 • 452 citations

tRNA Ligase Is Required for Regulated mRNA Splicing in the Unfolded Protein Response

1996 • 440 citations

Ligand-independent Dimerization Activates the Stress Response Kinases IRE1 and PERK in the Lumen of the Endoplasmic Reticulum

2000 • 408 citations

Signalling from endoplasmic reticulum to nucleus: transcription factor with a basic‐leucine zipper motif is required for the unfolded protein‐response pathway

1996 • 363 citations

Diabetes and tolerance in transgenic mice expressing class II MHC molecules in pancreatic beta cells

1988 • 343 citations

WFS1 (Wolfram syndrome 1) gene product: predominant subcellular localization to endoplasmic reticulum in cultured cells and neuronal expression in rat brain

2001 • 331 citations

Translational control of proinsulin synthesis by glucose

1980 • 310 citations

Identification of novel stress-induced genes downstream of chop

1998 • 306 citations

Dissociation of Kar2p/BiP from an ER Sensory Molecule, Ire1p, Triggers the Unfolded Protein Response in Yeast

2000 • 302 citations

Endoplasmic Reticulum Stress-induced mRNA Splicing Permits Synthesis of Transcription Factor Hac1p/Ern4p That Activates the Unfolded Protein Response

1997 • 283 citations

Integration of endoplasmic reticulum signaling in health and disease

1999 • 280 citations

IRE1 and efferent signaling from the endoplasmic reticulum

2000 • 259 citations

5 Mechanism and Regulation of Initiator Methionyl-tRNA Binding to Ribosomes

2000 • 246 citations

Disrupted Proteolipid Protein Trafficking Results in Oligodendrocyte Apoptosis in an Animal Model of Pelizaeus-Merzbacher Disease

1998 • 217 citations

Degradation of Proteins from the ER of S. cerevisiae Requires an Intact Unfolded Protein Response Pathway

2000 • 185 citations

Molecular basis of autosomal dominant neurohypophyseal diabetes insipidus. Cellular toxicity caused by the accumulation of mutant vasopressin precursors within the endoplasmic reticulum.

1997 • 171 citations

Pancreatic eukaryotic initiation factor-2α kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress

2000 • 147 citations

GADD153/CHOP, a DNA damage-inducible protein, reduced CAAT/enhancer binding protein activities and increased apoptosis in 32D c13 myeloid cells.

1996 • 144 citations

Compensatory responses in mice carrying a null mutation for Ins1 or Ins2.

2001 • 134 citations

Targeting of the c-Abl Tyrosine Kinase to Mitochondria in Endoplasmic Reticulum Stress-Induced Apoptosis

2001 • 129 citations

Pancreatic eukaryotic initiation factor-2α kinase (PEK) homologues in humans, Drosophila melanogaster and Caenorhabditis elegans that mediate translational control in response to endoplasmic reticulum stress

2000 • 109 citations

In situ hybridization studies suggest a role for the basic region‐leucine zipper protein hXBP‐1 in exocrine gland and skeletal development during mouse embryogenesis

1993 • 97 citations

Effects of glucose concentration on incorporation of [3H]leucine into insulin using isolated mammalian islets of Langerhans

1966 • 72 citations

MHC Molecules and β-Cell Destruction: Immune and Nonimmune Mechanisms

1989 • 52 citations

The Perks of Balancing Glucose

2001 • 22 citations

MHC molecules and beta-cell destruction. Immune and nonimmune mechanisms

1989 • 16 citations