Clinical validation of the “in silico” prediction of immunogenicity of a human recombinant therapeutic protein

Influence of Immunogenicity on the Long-Term Efficacy of Infliximab in Crohn's Disease

2003 • 1,990 citations

Pure Red-Cell Aplasia and Antierythropoietin Antibodies in Patients Treated with Recombinant Erythropoietin

2002 • 1,221 citations

Universally immunogenic T cell epitopes: promiscuous binding to human MHC class II and promiscuous recognition by T cells

1989 • 706 citations

Thrombocytopenia caused by the development of antibodies to thrombopoietin

2001 • 670 citations

Several Common HLA-DR Types Share Largely Overlapping Peptide Binding Repertoires

1998 • 647 citations

Suppression of angiogenesis and tumor growth by selective inhibition of angiopoietin-2

2004 • 473 citations

The exogenous pathway for antigen presentation on major histocompatibility complex class II and CD1 molecules

2004 • 256 citations

From genome to vaccine: in silico predictions, ex vivo verification

2001 • 173 citations

Immuno‐informatics: Mining genomes for vaccine components

2002 • 167 citations

Rationally Engineered Therapeutic Proteins with Reduced Immunogenicity

2005 • 165 citations

Direct Visualization of Cytokine-Producing Recall Antigen-Specific CD4 Memory T Cells in Healthy Individuals and HIV Patients

2000 • 129 citations

Prediction of well-conserved HIV-1 ligands using a matrix-based algorithm, EpiMatrix

1998 • 104 citations

An Interactive Web Site Providing Major Histocompatibility Ligand Predictions: Application to HIV Research

1997 • 101 citations

Immunogenicity of biological therapeutics: a hierarchy of concerns.

2003 • 95 citations

Evaluation of Methods to Detect and Characterize Antibodies against Recombinant Human Erythropoietin

2004 • 94 citations

In Silico Prediction of Peptides Binding to Multiple HLA-DR Molecules Accurately Identifies Immunodominant Epitopes from gp43 of Paracoccidioides brasiliensis Frequently Recognized in Primary Peripheral Blood Mononuclear Cell Responses from Sensitized Individuals

2003 • 91 citations

Clinical link between MHC class II haplotype and interferon-beta (IFN-β) immunogenicity

2005 • 86 citations

Enhanced immunogenicity of HIV-1 vaccine construct by modification of the native peptide sequence

1997 • 77 citations

Mapping cross-clade HIV-1 vaccine epitopes using a bioinformatics approach

2003 • 76 citations

De-immunization of therapeutic proteins by T-cell epitope modification.

2005 • 73 citations

Naive and memory B cells in T-cell-dependent and T-independent responses

2001 • 63 citations

Validation of the BIACORE 3000 platform for detection of antibodies against erythropoietic agents in human serum samples

2003 • 54 citations

An In Vitro Human Cell-Based Assay to Rank the Relative Immunogenicity of Proteins

2003 • 23 citations

Probable epitopes

2004 • 8 citations

Deleted Work

1955 • 0 citations