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Innate Immune Recognition

2002 • 8,157 citations

CD4+CD25+ suppressor T cells: more questions than answers

2002 • 2,202 citations

Natural versus adaptive regulatory T cells

2003 • 1,363 citations

Effects of protein aggregates: An immunologic perspective

2006 • 1,263 citations

Pure Red-Cell Aplasia and Antierythropoietin Antibodies in Patients Treated with Recombinant Erythropoietin

2002 • 1,221 citations

Generation of tissue-specific and promiscuous HLA ligand databases using DNA microarrays and virtual HLA class II matrices

1999 • 747 citations

Recommendations for the design and optimization of immunoassays used in the detection of host antibodies against biotechnology products

2004 • 593 citations

Evidence that the T cell repertoire of normal rats contains cells with the potential to cause diabetes. Characterization of the CD4+ T cell subset that inhibits this autoimmune potential.

1993 • 442 citations

CEP: a conformational epitope prediction server

2005 • 286 citations

Viral immune evasion: a masterpiece of evolution

2002 • 248 citations

Towards a consensus on datasets and evaluation metrics for developing B‐cell epitope prediction tools

2007 • 237 citations

The Kinetic Stability of MHC Class II:Peptide Complexes Is a Key Parameter that Dictates Immunodominance

2005 • 221 citations

Antibiotic-refractory Lyme arthritis is associated with HLA-DR molecules that bind aBorrelia burgdorferipeptide

2006 • 202 citations

Detection of GAD65-Specific T-Cells by Major Histocompatibility Complex Class II Tetramers in Type 1 Diabetic Patients and At-Risk Subjects

2002 • 198 citations

Utilization of MHC Class I Transgenic Mice for Development of Minigene DNA Vaccines Encoding Multiple HLA-Restricted CTL Epitopes

1999 • 166 citations

Rationally Engineered Therapeutic Proteins with Reduced Immunogenicity

2005 • 165 citations

CTL responses of HLA-A2.1-transgenic mice specific for hepatitis C viral peptides predict epitopes for CTL of humans carrying HLA-A2.1.

1995 • 165 citations

Evolution of the T Cell Repertoire During Primary, Memory, and Recall Responses to Viral Infection

2000 • 150 citations

HLA-DRB1 polymorphism determines susceptibility to autoimmune thyroiditis in transgenic mice: definitive association with HLA-DRB1*0301 (DR3) gene.

1996 • 138 citations

Clinical validation of the “in silico” prediction of immunogenicity of a human recombinant therapeutic protein

2007 • 135 citations

Structural principles that govern the peptide-binding motifs of class I MHC molecules

1998 • 122 citations

Antibodies to recombinant human erythropoietin causing pure red cell aplasia.

1997 • 117 citations

A molecular immunology approach to antibody humanization and functional optimization

2006 • 102 citations

T Cell Epitopes of Human Myelin Oligodendrocyte Glycoprotein Identified in HLA-DR4 (DRB1*0401) Transgenic Mice Are Encephalitogenic and Are Presented by Human B Cells

2001 • 95 citations

3D‐Epitope‐Explorer (3DEX): Localization of conformational epitopes within three‐dimensional structures of proteins

2005 • 92 citations

Genetic analysis of host–parasite coevolution in human malaria

1997 • 87 citations

Clinical link between MHC class II haplotype and interferon-beta (IFN-β) immunogenicity

2005 • 86 citations

Definition of a human T cell epitope from influenza A non-structural protein 1 using HLA-A2.1 transgenic mice

1995 • 84 citations

Elimination of an Immunodominant CD4+ T Cell Epitope in Human IFN-β Does Not Result in an In Vivo Response Directed at the Subdominant Epitope

2004 • 80 citations

Genome-derived vaccines

2004 • 78 citations

An empirical method for the prediction of T-cell epitopes

1995 • 73 citations

De-immunization of therapeutic proteins by T-cell epitope modification.

2005 • 73 citations

Enumerating Antigen-Specific T-Cell Responses in Peripheral Blood

2004 • 71 citations

Challenges to the development of antigen-specific breast cancer vaccines

2001 • 56 citations

Novel erythropoiesis stimulating protein for managing the anemia of chronic kidney disease

2001 • 56 citations

HLA-DR4 (DRB1*0401) Transgenic Mice Expressing an Altered CD4-Binding Site: Specificity and Magnitude of DR4-Restricted T Cell Response

1998 • 53 citations

BCR-ABL fusion regions as a source of multiple leukemia-specific CD8+ T-cell epitopes

2006 • 40 citations

An in silico method using an epitope motif database for predicting the location of antigenic determinants on proteins in a structural context

2005 • 33 citations

Cognate T Cell Help Is Sufficient to Trigger Anti-Nuclear Autoantibodies in Naive Mice

2001 • 30 citations

DNA Immunization of HLA Transgenic Mice with a Plasmid Expressing Mycobacterial Heat Shock Protein 65 Results in HLA Class I- and II-Restricted T Cell Responses That Can Be Augmented by Cytokines

2001 • 23 citations

Viral escape from immune recognition: Multiple strategies of adenoviruses

1992 • 21 citations

Modelling the immunogenicity of therapeutic proteins using T cell epitope mapping.

2003 • 16 citations

Untitled

2004 • 11 citations