Innate immune sensing of pathogens and danger signals by cell surface Toll-like receptors

Innate Immune Recognition

2002 • 8,157 citations

Toll-Like Receptors

2003 • 6,127 citations

The repertoire for pattern recognition of pathogens by the innate immune system is defined by cooperation between Toll-like receptors

2000 • 2,076 citations

Structure and Function of Lipopolysaccharide Binding Protein

1990 • 1,689 citations

Cutting Edge: Heat Shock Protein 60 Is a Putative Endogenous Ligand of the Toll-Like Receptor-4 Complex

2000 • 1,632 citations

Involvement of Toll-like Receptors 2 and 4 in Cellular Activation by High Mobility Group Box 1 Protein

2004 • 1,533 citations

Regulation of lung injury and repair by Toll-like receptors and hyaluronan

2005 • 1,360 citations

Oligosaccharides of Hyaluronan Activate Dendritic Cells via Toll-like Receptor 4

2002 • 1,339 citations

Cutting Edge: Role of Toll-Like Receptor 1 in Mediating Immune Response to Microbial Lipoproteins

2002 • 1,309 citations

The Extra Domain A of Fibronectin Activates Toll-like Receptor 4

2001 • 1,200 citations

The nuclear factor HMGB1 mediates hepatic injury after murine liver ischemia-reperfusion

2005 • 1,063 citations

Marginal Zone and B1 B Cells Unite in the Early Response against T-Independent Blood-Borne Particulate Antigens

2001 • 955 citations

HSP70 as Endogenous Stimulus of the Toll/Interleukin-1 Receptor Signal Pathway

2002 • 949 citations

Control of Early Viral and Bacterial Distribution and Disease by Natural Antibodies

1999 • 895 citations

Toll-Like Receptor 4-Dependent Activation of Dendritic Cells by β-Defensin 2

2002 • 885 citations

Toll-like receptor function and signaling

2006 • 873 citations

CD36 is a sensor of diacylglycerides

2005 • 846 citations

Endocytosed HSP60s Use Toll-like Receptor 2 (TLR2) and TLR4 to Activate the Toll/Interleukin-1 Receptor Signaling Pathway in Innate Immune Cells

2001 • 800 citations

Phosphoinositide-Mediated Adaptor Recruitment Controls Toll-like Receptor Signaling

2006 • 797 citations

The matrix component biglycan is proinflammatory and signals through Toll-like receptors 4 and 2 in macrophages

2005 • 794 citations

GENETIC ANALYSIS OF HOST RESISTANCE: Toll-Like Receptor Signaling and Immunity at Large

2006 • 775 citations

Endogenous ligands of Toll-like receptors

2004 • 689 citations

Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA

2005 • 649 citations

CD14 is required for MyD88-independent LPS signaling

2005 • 645 citations

B-1 and B-2 Cell–Derived Immunoglobulin M Antibodies Are Nonredundant Components of the Protective Response to Influenza Virus Infection

2000 • 572 citations

Recognition of microbial infection by Toll-like receptors

2003 • 556 citations

The Endoplasmic Reticulum-resident Heat Shock Protein Gp96 Activates Dendritic Cells via the Toll-like Receptor 2/4 Pathway

2002 • 496 citations

Specific Lipopolysaccharide Found in Cystic Fibrosis Airway Pseudomonas aeruginosa

1999 • 484 citations

Autoreactivity by design: innate B and T lymphocytes

2001 • 409 citations

Minimally Modified LDL Binds to CD14, Induces Macrophage Spreading via TLR4/MD-2, and Inhibits Phagocytosis of Apoptotic Cells

2003 • 398 citations

Virulence factors of Yersinia pestis are overcome by a strong lipopolysaccharide response

2006 • 387 citations

Lipopolysaccharide Interaction with Cell Surface Toll-like Receptor 4-MD-2

2003 • 378 citations

Isolation of an endotoxin–MD-2 complex that produces Toll-like receptor 4-dependent cell activation at picomolar concentrations

2004 • 367 citations

Negative regulation of Toll-like receptor 4 signaling by the Toll-like receptor homolog RP105

2005 • 367 citations

Endoplasmic reticulum chaperone gp96 is required for innate immunity but not cell viability

2001 • 349 citations

Lipopolysaccharide Binding Protein-mediated Complexation of Lipopolysaccharide with Soluble CD14

1995 • 331 citations

Innate recognition of lipopolysaccharide by Toll-like receptor 4–MD-2

2004 • 330 citations

MD-2 Binds to Bacterial Lipopolysaccharide

2001 • 308 citations

Cutting Edge: The Immunostimulatory Activity of the Lung Surfactant Protein-A Involves Toll-Like Receptor 4

2002 • 306 citations

The Toll-like Receptor Protein Rp105 Regulates Lipopolysaccharide Signaling in B Cells

2000 • 302 citations

Identification of Small Heat Shock Protein B8 (HSP22) as a Novel TLR4 Ligand and Potential Involvement in the Pathogenesis of Rheumatoid Arthritis

2006 • 267 citations

The myristoylation of TRIF-related adaptor molecule is essential for Toll-like receptor 4 signal transduction

2006 • 263 citations

TLR1- and TLR6-independent Recognition of Bacterial Lipopeptides

2006 • 247 citations

ML — a conserved domain involved in innate immunity and lipid metabolism

2002 • 243 citations

Lysines 128 and 132 Enable Lipopolysaccharide Binding to MD-2, Leading to Toll-like Receptor-4 Aggregation and Signal Transduction

2003 • 238 citations

Lipid A antagonist, lipid IVa, is distinct from lipid A in interaction with Toll-like receptor 4 (TLR4)-MD-2 and ligand-induced TLR4 oligomerization

2004 • 232 citations

Differential Induction of the Toll-Like Receptor 4-MyD88-Dependent and -Independent Signaling Pathways by Endotoxins

2005 • 221 citations

RP105, a novel B cell surface molecule implicated in B cell activation, is a member of the leucine-rich repeat protein family.

1995 • 200 citations

Cell surface expression of an endoplasmic reticulum resident heat shock protein gp96 triggers MyD88-dependent systemic autoimmune diseases

2003 • 172 citations

Regulatory Roles for MD-2 and TLR4 in Ligand-Induced Receptor Clustering

2006 • 159 citations

Mouse MD-1, a Molecule That Is Physically Associated with RP105 and Positively Regulates Its Expression

1998 • 150 citations

The Crystal Structure of a Major Dust Mite Allergen Der p 2, and its Biological Implications

2002 • 147 citations

Murine B cell proliferation and protection from apoptosis with an antibody against a 105-kD molecule: unresponsiveness of X-linked immunodeficient B cells.

1994 • 138 citations

Innate recognition of lipopolysaccharide by CD14 and toll-like receptor 4-MD-2: unique roles for MD-2

2003 • 128 citations

Interaction of Soluble Form of Recombinant Extracellular TLR4 Domain with MD-2 Enables Lipopolysaccharide Binding and Attenuates TLR4-Mediated Signaling

2004 • 109 citations

Lipopeptide structure determines TLR2 dependent cell activation level

2005 • 105 citations

A Protein Associated with Toll-Like Receptor 4 (PRAT4A) Regulates Cell Surface Expression of TLR4

2006 • 104 citations

Separate Functional Domains of Human MD-2 Mediate Toll-Like Receptor 4-Binding and Lipopolysaccharide Responsiveness

2003 • 104 citations

MD-2: the Toll ?gatekeeper? in endotoxin signalling

2004 • 102 citations

The Radioprotective 105/MD-1 Complex Links TLR2 and TLR4/MD-2 in Antibody Response to Microbial Membranes

2005 • 92 citations

Overexpression of Toll-Like Receptor 4 Amplifies the Host Response to Lipopolysaccharide and Provides a Survival Advantage in Transgenic Mice

2003 • 91 citations

Identification of LPS-Binding Peptide Fragment of MD-2, a Toll-Receptor Accessory Protein

2002 • 68 citations

Structural Regions of MD-2 That Determine the Agonist-Antagonist Activity of Lipid IVa

2006 • 67 citations

Lipopolysaccharide-Binding Protein Critically Regulates Lipopolysaccharide-Induced IFN-β Signaling Pathway in Human Monocytes

2004 • 59 citations

Localization of the Lipopolysaccharide-binding Protein in Phospholipid Membranes by Atomic Force Microscopy

2005 • 26 citations

Abrupt Expression of TLR4 in TLR4-Deficient Macrophages Imposes a Selective Disadvantage: Genetic Evidence for TLR4-Dependent Responses to Endogenous, Nonmicrobial Stimuli

2006 • 2 citations