The discovery and development of HMG-CoA reductase inhibitors.

Regulation of the mevalonate pathway

1990 • 5,282 citations

The Low-Density Lipoprotein Pathway and its Relation to Atherosclerosis

1977 • 2,481 citations

Regression of Coronary Artery Disease as a Result of Intensive Lipid-Lowering Therapy in Men with High Levels of Apolipoprotein B

1990 • 2,192 citations

All ras proteins are polyisoprenylated but only some are palmitoylated

1989 • 1,806 citations

Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.

1980 • 1,607 citations

Seven Countries: A Multivariate Analysis of Death and Coronary Heart Disease.

1980 • 1,450 citations

Receptor-Mediated Control of Cholesterol Metabolism

1976 • 957 citations

ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogensis produced by Penicillium citrinum.

1976 • 926 citations

Competitive inhibition of 3‐hydroxy‐3‐methylglutaryl coenzyme a reductase by ML‐236A and ML‐236B fungal metabolites, having hypocholesterolemic activity

1976 • 788 citations

HMG-CoA Reductase Inhibitors for Treatment of Hypercholesterolemia

1988 • 760 citations

Influence of nicotinic acid on serum cholesterol in man

1955 • 696 citations

Familial hypercholesterolemia: Defective binding of lipoproteins to cultured fibroblasts associated with impaired regulation of 3-hydroxy-3-methylglutaryl coenzyme a reductase activity

1974 • 589 citations

Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes.

1983 • 562 citations

Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase

1978 • 556 citations

Genetic and Pharmacological Suppression of Oncogenic Mutations in RAS Genes of Yeast and Humans

1989 • 535 citations

Regulatory role for hepatic low density lipoprotein receptors in vivo in the dog.

1981 • 424 citations

CS-514, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase: tissue-selective inhibition of sterol synthesis and hypolipidemic effect on various animal species

1986 • 376 citations

Regulation of Cholesterol Metabolism

1970 • 358 citations

Relation of cholesterol and mevalonic acid to the cell cycle in smooth muscle and swiss 3T3 cells stimulated to divide by platelet-derived growth factor.

1980 • 353 citations

Crystal and molecular structure of compactin, a new antifungal metabolite from Penicillium brevicompactum

1976 • 351 citations

Regulation of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Activity in Human Fibroblasts by Lipoproteins

1973 • 348 citations

Regulation of Cholesterol Metabolism

1970 • 341 citations

Modification of Metabolism and Distribution of Lipids by Ethyl Chlorophenoxyisobutyrate

1962 • 337 citations

Feedback Control of Mevalonate Synthesis by Dietary Cholesterol

1966 • 332 citations

Mevinolin, an inhibitor of cholesterol synthesis, induces mRNA for low density lipoprotein receptor in livers of hamsters and rabbits.

1986 • 331 citations

Reduction of Blood Cholesterol in Man

1953 • 325 citations

Domain structure of 3-hydroxy-3-methylglutaryl coenzyme A reductase, a glycoprotein of the endoplasmic reticulum.

1985 • 301 citations

Essential role for mevalonate synthesis in DNA replication

1979 • 297 citations

Effect of cholesterol feeding and fasting on sterol synthesis in seventeen tissues of the rat

1967 • 296 citations

Compactin (ML-236B) and related compounds as potential cholesterol-lowering agents that inhibit HMG-CoA reductase

1985 • 285 citations

Nucleotide sequence of 3-hydroxy-3-methyl-glutaryl coenzyme A reductase, a glycoprotein of endoplasmic reticulum

1984 • 263 citations

Effects of an Inhibitor of 3-Hydroxy-3-Methylglutaryl Coenzyme a Reductase on Serum Lipoproteins and Ubiquinone-10 Levels in Patients with Familial Hypercholesterolemia

1981 • 262 citations

3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 4. Side-chain ester derivatives of mevinolin

1986 • 261 citations

Inhibition of Cholesterol Synthesis in vitro and in vivo by ML‐236A and ML‐236B, Competitive Inhibitors of 3‐Hydroxy‐3‐methylglutaryl‐Coenzyme A Reductase

1977 • 261 citations

Evidence for modification of lamin B by a product of mevalonic acid.

1988 • 254 citations

Inhibitory Effects on Lipid Metabolismn in Cultured Cells of ML‐236B, a Potent Inhibitor of 3‐Hydroxt‐3‐methylglutaryl‐Cornzyme‐A Reductase

1978 • 252 citations

Appearance of crystalloid endoplasmic reticulum in compactin-resistant Chinese hamster cells with a 500-fold increase in 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

1982 • 248 citations

Evidence for post-translational incorporation of a product of mevalonic acid into Swiss 3T3 cell proteins.

1984 • 236 citations

Monacolin K, a new hypocholesterolemic agent that specifically inhibits 3-hydroxy-3-methylglutaryl coenzyme A reductase.

1980 • 236 citations

Regulation of Cholesterol Biosynthesis in Normal and Malignant Tissues* *This research was supported by U. S. Public Health Service Grants CA-08501, CA-05200, and Research Career Award HE-01958, and by the Damon Runyon Memorial Fund Award No. 747.

1970 • 232 citations

Therapeutic effects of ML-236B in primary hypercholesterolemia

1980 • 231 citations

Cholesterol synthesis in the squirrel monkey: relative rates of synthesis in various tissues and mechanisms of control

1968 • 220 citations

Simvastatin

1990 • 219 citations

Effects of ML-236B on cholesterol metabolism in mice and rats: Lack of hypocholesterolemic activity in normal animals

1979 • 218 citations

Lovastatin (Mevinolin) in the Treatment of Heterozygous Familial Hypercholesterolemia

1987 • 215 citations

Influence of mevinolin on metabolism of low density lipoproteins in primary moderate hypercholesterolemia.

1985 • 210 citations

Prevention of Cyclic and Triton-induced Increases in Hydroxymethylglutaryl Coenzyme A Reductase and Sterol Synthesis by Puromycin

1969 • 208 citations

Cholesterol-lowering effect of mevinolin, an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme a reductase, in healthy volunteers.

1982 • 206 citations

Cholesterol Biosynthesis in Preparations of Liver from Normal, Fasting, X-irradiated, Cholesterol-fed, Triton, or Δ4-Cholesten-3-one-treated Rats

1959 • 203 citations

Reduction of Serum Cholesterol in Heterozygous Patients with Familial Hypercholesterolemia

1983 • 201 citations

Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its mRNA in rat liver as studied with a monoclonal antibody and a cDNA probe.

1983 • 200 citations

Amplification of the gene for 3-hydroxy-3-methylglutaryl coenzyme A reductase, but not for the 53-kDa protein, in UT-1 cells.

1983 • 200 citations

HMG CoA reductase inhibitors

1992 • 195 citations

The ras oncogene--an important regulatory element in lower eucaryotic organisms

1989 • 189 citations

Incorporation of a product of mevalonic acid metabolism into proteins of Chinese hamster ovary cell nuclei.

1988 • 181 citations

Improved assay of 3-hydroxy-3-methylglutaryl coenzyme A reductase

1971 • 177 citations

Hypocholesterolemic effects of mevinolin in patients with heterozygous familial hypercholesterolemia.

1984 • 176 citations

Therapeutic response to lovasatain (Mevinolin) in nonfamilial hypercholesterolemia - A Multicenter study

1986 • 175 citations

Plasma mevalonate as a measure of cholesterol synthesis in man.

1984 • 163 citations

Therapeutic Response to Lovastatin (Mevinolin) in Nonfamilial Hypercholesterolemia

1986 • 160 citations

Plasma cholesterol lowering action of bile acid binding polymers in experimental animals

1960 • 159 citations

Lovastatin for Lowering Cholesterol Levels in Non-Insulin-Dependent Diabetes Mellitus

1988 • 158 citations

EFFECTS OF SYNVINOLIN (MK-733) ON PLASMA LIPIDS IN FAMILIAL HYPERCHOLESTEROLAEMIA

1986 • 157 citations

Molecular cloning of 3-hydroxy-3-methylglutaryl coenzyme a reductase and evidence for regulation of its mRNA.

1982 • 147 citations

Mevinolin Plus Colestipol in Therapy for Severe Heterozygous Familial Hypercholesterolemia

1984 • 132 citations

Lovastatin therapy in nephrotic hyperlipidemia: Effects on lipoprotein metabolism

1988 • 129 citations

Combination Drug Therapy for Familial Combined Hyperlipidemia

1988 • 127 citations

Inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase by mevinolin in familial hypercholesterolemia heterozygotes: effects on cholesterol balance.

1984 • 124 citations

Pravastatin therapy in primary moderate hypercholesterolaemia: changes in metabolism of apolipoprotein B‐containing lipoproteins

1990 • 118 citations

Hypolipidemic effects in dogs of ML-236B, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme a reductase

1979 • 110 citations

Influence of Combined Therapy with Mevinolin and Interruption of Bile-Acid Reabsorption on Low Density Lipoproteins in Heterozygous Familial Hypercholesterolemia

1985 • 108 citations

Lipoprotein receptors, cholesterol metabolism, and atherosclerosis.

1975 • 104 citations

Mode of interaction of .beta.-hydroxy-.beta.-methylglutaryl coenzyme A reductase with strong binding inhibitors: compactin and related compounds

1985 • 102 citations

Citrinin, an inhibitor of cholesterol synthesis.

1976 • 102 citations

Cataracts in Patients Treated with Triparanol

1962 • 101 citations

Mechanism for elevation of hepatic cholesterol synthesis and serum cholesterol levels in triton WR-1339-induced hyperlipidemia

1977 • 89 citations

Effectiveness of mevinolin on plasma lipoprotein concentrations in type II hyperlipoproteinemia

1986 • 86 citations

Lovastatin therapy in familial dysbetalipoproteinemia: Effects on kinetics of apolipoprotein B

1988 • 83 citations

Lovastatin therapy in receptor-negative homozygous familial hypercholesterolemia: Lack of effect on low-density lipoprotein concentrations or turnover

1988 • 82 citations

Hypolipidemic effects in monkeys of ML‐236B, a competitive inhibitor of 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase

1979 • 81 citations

The Effect of CS-514 on Serum Lipids and Apolipoproteins in Hypercholesterolemic Subjects

1987 • 79 citations

Efficacy and safety of pravastatin in patients with primary hypercholesterolemia

1990 • 77 citations

THE INFLUENCE OF INTRAVENOUSLY ADMINISTERED SURFACE-ACTIVE AGENTS ON THE DEVELOPMENT OF EXPERIMENTAL ATHEROSCLEROSIS IN RABBITS

1951 • 71 citations

Synthesis and biological activity of new HMG-CoA reductase inhibitors. 1. Lactones of pyridine- and pyrimidine-substituted 3,5-dihydroxy-6-heptenoic (-heptanoic) acids

1990 • 70 citations

A study of the Influence of mevalonic acid and its metabolites on the morphology of swiss 3T3 cells.

1982 • 70 citations

Regulation of Hmg-coa Reductase

1985 • 67 citations

Lowering of Serum Lipid Concentrations

1960 • 65 citations

The Biosynthesis of Mevalonic Acid from 1-C14-Acetate by a Rat Liver Enzyme System

1959 • 62 citations

Hypolipidemic effects of HMG-CoA reductase inhibitors in patients with hypercholesterolemia

1987 • 62 citations

Kinetic Analysis of the Reaction Catalyzed by Rat‐Liver 3‐Hydroxy‐3‐methylglutaryl‐coenzyme‐A Reductase Using Two Specific Inhibitors

1979 • 61 citations

Effects of fluvastatin (XU 62-320), an HMG-CoA reductase inhibitor, on the distribution and composition of low density lipoprotein subspecies in humans

1991 • 61 citations

Effects of CS-514 on serum lipoprotein lipid and apolipoprotein levels in patients with familial hypercholesterolemia

1987 • 54 citations

Comparative efficacy of once versus twice daily mevinolin in the therapy of familial hypercholesterolemia

1986 • 52 citations

Reduction of Serum Cholesterol by Sodium Dextro-Thyroxine

1960 • 51 citations

Preliminary report: Treatment of type 3 hyperlipoproteinemia with mevinolin

1986 • 51 citations

Effects of simvastatin and probucol in hypercholesterolemia (simvastatin multicenter study group II)

1989 • 50 citations

A role for isoprenoid lipids in the localization and function of an oncoprotein.

1990 • 37 citations

The efficacy and safety of pravastatin, compared to and in combination with bile acid binding resins, in familial hypercholesterolaemia

1990 • 36 citations

Mevalonolactone derivatives as inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase.

1980 • 34 citations

The prenylation of proteins

1991 • 33 citations

Safety, Tolerability, and Efficacy of Simvastatin and Fenofibrate - A Multicenter Study

1990 • 32 citations

Triton hypercholesteremia: cause or consequence of augmented cholesterol synthesis

1963 • 26 citations

Microbial hydroxylation of compactin (ML-236B) and monacolin K.

1985 • 23 citations

Time-dependent, irreversible inhibition of 3-hydroxy-3-methylglutaryl-coenzyme a reductase by the antibiotic citrinin

1977 • 23 citations

Improvement in the Regulation of Cellular Cholesterologenesis in Diabetes: the Effect of Reduction in Serum Cholesterol by Simvastatin

1991 • 18 citations

SPECIFIC INHIBITION OF DESMOSTEROL SYNTHESIS BY ML-236B IN MOUSE LM CELLS GROWN IN SUSPENSION IN A LIPID-FREE MEDIUM

1978 • 17 citations

Combined drug therapy--cholestyramine and compactin--for familial hypercholesterolemia.

1984 • 17 citations

Specific Nonsterol Inhibitors of HMG-CoA Reductase

1985 • 12 citations

Two Japanese Kindreds of Familial Hypercholesterolemia Including Homozygous Cases. A Report of Cases, and Studies on Serum-Lipoproteins and Enzymes

1978 • 11 citations

The effects of an inhibitor of cholesterol biosynthesis triparanol (MER-29), in subjects with and without coronary artery disease.

1959 • 9 citations

Nutrition and therapeutics

1992 • 2 citations

Nutrition and therapeutics: Editorial Overview

1990 • 1 citations