Regulation of 3-hydroxy-3-methylglutaryl coenzyme A reductase and its mRNA in rat liver as studied with a monoclonal antibody and a cDNA probe.

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

Continuous cultures of fused cells secreting antibody of predefined specificity

1975 • 17,037 citations

Labeling deoxyribonucleic acid to high specific activity in vitro by nick translation with DNA polymerase I

1977 • 12,015 citations

Purification of Biologically Active Globin Messenger RNA by Chromatography on Oligothymidylic acid-Cellulose

1972 • 6,922 citations

A simple, rapid, and sensitive DNA assay procedure

1980 • 5,006 citations

Multivalent feedback regulation of HMG CoA reductase, a control mechanism coordinating isoprenoid synthesis and cell growth.

1980 • 1,195 citations

Competitive inhibition of 3‐hydroxy‐3‐methylglutaryl coenzyme a reductase by ML‐236A and ML‐236B fungal metabolites, having hypocholesterolemic activity

1976 • 788 citations

Variety in the level of gene control in eukaryotic cells

1982 • 772 citations

Regulation of HMG-CoA Reductase

1976 • 743 citations

Identification of procollagen mRNAs transferred to diazobenzyloxymethyl paper from formaldehyde agarose gels

1979 • 564 citations

Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase

1978 • 556 citations

Regulation of 3-Hydroxy-3-methylglutaryl Coenzyme A Reductase Activity in Cultured Human Fibroblasts

1974 • 545 citations

Cell surface antigens of human malignant melanoma: definition of six antigenic systems with mouse monoclonal antibodies.

1980 • 522 citations

The transfer and stable integration of the HSV thymidine kinase gene into mouse cells

1978 • 382 citations

[45] The use of intensifying screens or organic scintillators for visualizing radioactive molecules resolved by gel electrophoresis

1980 • 367 citations

Monoclonal antibodies to the low density lipoprotein receptor as probes for study of receptor-mediated endocytosis and the genetics of familial hypercholesterolemia.

1981 • 359 citations

Active and inactive forms of 3-hydroxy-3-methylglutaryl coenzyme A reductase in the liver of the rat. Comparison with the rate of cholesterol synthesis in different physiological states.

1979 • 309 citations

Feedback Regulation of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase in Livers of Mice Treated with Mevinolin, a Competitive Inhibitor of the Reductase

1980 • 305 citations

Appearance of crystalloid endoplasmic reticulum in compactin-resistant Chinese hamster cells with a 500-fold increase in 3-hydroxy-3-methylglutaryl-coenzyme A reductase.

1982 • 248 citations

3-Hydroxy-3-methylglutaryl Coenzyme A Reductase

1973 • 240 citations

Effects of ML-236B on cholesterol metabolism in mice and rats: Lack of hypocholesterolemic activity in normal animals

1979 • 218 citations

Regulation of synthesis and degradation of 3-hydroxy-3-methylglutaryl-coenzyme A reductase by low density lipoprotein and 25-hydroxycholesterol in UT-1 cells.

1982 • 203 citations

Immunoblot analysis of low density lipoprotein receptors in fibroblasts from subjects with familial hypercholesterolemia.

1982 • 175 citations

Molecular cloning of 3-hydroxy-3-methylglutaryl coenzyme a reductase and evidence for regulation of its mRNA.

1982 • 147 citations

Radioimmune precipitation of 3-hydroxy-3-methylglutaryl coenzyme A reductase from Chinese hamster fibroblasts. Effect of 25-hydroxycholesterol.

1981 • 93 citations

The kinetic characteristics of inhibition of hepatic cholesterogenesis by lipoproteins of intestinal origin

1975 • 89 citations

The effect of cholestyramine and Mevinolin on the diurnal cycle of rat hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase

1982 • 65 citations

In vivo and in vitro mechanisms regulating rat liver beta-hydroxy-beta-methylglutaryl coenzyme A reductase activity.

1980 • 52 citations

Identification of a cholesterol-regulated 53,000-dalton cytosolic protein in UT-1 cells and cloning of its cDNA.

1982 • 27 citations