Effects of ML-236B on cholesterol metabolism in mice and rats: Lack of hypocholesterolemic activity in normal animals

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogensis produced by Penicillium citrinum.

1976 • 926 citations

Competitive inhibition of 3‐hydroxy‐3‐methylglutaryl coenzyme a reductase by ML‐236A and ML‐236B fungal metabolites, having hypocholesterolemic activity

1976 • 788 citations

Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase

1978 • 556 citations

Cholesterol 7α-hydroxylase

1977 • 504 citations

Atherosclerosis: The low-density lipoprotein receptor hypothesis

1977 • 341 citations

Inhibition of Cholesterol Synthesis in vitro and in vivo by ML‐236A and ML‐236B, Competitive Inhibitors of 3‐Hydroxy‐3‐methylglutaryl‐Coenzyme A Reductase

1977 • 261 citations

Inhibitory Effects on Lipid Metabolismn in Cultured Cells of ML‐236B, a Potent Inhibitor of 3‐Hydroxt‐3‐methylglutaryl‐Cornzyme‐A Reductase

1978 • 252 citations

Triton‐induced hyperlipidemia in rats as an animal model for screening hypolipidemic drugs

1972 • 212 citations

Prevention of Cyclic and Triton-induced Increases in Hydroxymethylglutaryl Coenzyme A Reductase and Sterol Synthesis by Puromycin

1969 • 208 citations

The LDL Pathway in Human Fibroblasts: A Receptor-Mediated Mechanism for the Regulation of Cholesterol Metabolism

1976 • 183 citations

Effect of Glucose and Fructose Administration on Lipid Metabolism in the Rat

1968 • 150 citations

Regulation of 3-hydroxy-3-methylglutarate and mevalonate biosynthesis by rat liver homogenates. Effects of fasting, cholesterol feeding, and triton administration

1970 • 119 citations

Stimulatory effect of dietary lipid and cholestyramine on hepatic HMG CoA reductase

1972 • 111 citations

Hypolipidemic effects in dogs of ML-236B, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme a reductase

1979 • 110 citations

Disc electrophoresis of rat plasma lipoproteins

1966 • 103 citations

Cholesterol 7α-hydroxylase in rat liver microsomal preparations

1972 • 102 citations

Mechanism Underlying Hypercholesteremia Induced by Triton WR-1339

1957 • 92 citations

Mechanism for elevation of hepatic cholesterol synthesis and serum cholesterol levels in triton WR-1339-induced hyperlipidemia

1977 • 89 citations

Inhibition of in vitro cholesterol synthesis by fatty acids

1977 • 88 citations

Hypolipidemic effects in monkeys of ML‐236B, a competitive inhibitor of 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase

1979 • 81 citations

THE INFLUENCE OF INTRAVENOUSLY ADMINISTERED SURFACE-ACTIVE AGENTS ON THE DEVELOPMENT OF EXPERIMENTAL ATHEROSCLEROSIS IN RABBITS

1951 • 71 citations

Rapid increase in hepatic HMG CoA reductase activity and in vivo cholesterol synthesis after Triton WR 1339 injection.

1978 • 58 citations

Distribution of bile acids in rats

1978 • 48 citations

Effect of clofibrate on lipoprotein metabolism in hyperlipidemic rats

1972 • 46 citations

Effects of Estradiol, Dietary Cholesterol and 1-Thyroxine on Biliary Bile Acid Composition and Secretory Rate, and on Plasma, Liver and Bile Cholesterol Levels in Rats

1970 • 37 citations

Serum and liver lipid responses to 3‐hydroxy‐3‐methylglutaric acid in rats on different carbohydrate diets

1977 • 7 citations