Inhibition of 3-hydroxy-3-methylglutaryl-CoA reductase by mevinolin in familial hypercholesterolemia heterozygotes: effects on cholesterol balance.

The Low-Density Lipoprotein Pathway and its Relation to Atherosclerosis

1977 • 2,481 citations

Mevinolin: a highly potent competitive inhibitor of hydroxymethylglutaryl-coenzyme A reductase and a cholesterol-lowering agent.

1980 • 1,607 citations

Quantitative isolation and gas–liquid chromatographic analysis of total fecal bile acids

1965 • 891 citations

Quantitative isolation and gas–liquid chromatographic analysis of total dietary and fecal neutral steroids

1965 • 760 citations

Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes.

1983 • 562 citations

Induction of 3-hydroxy-3-methylglutaryl coenzyme A reductase activity in human fibroblasts incubated with compactin (ML-236B), a competitive inhibitor of the reductase

1978 • 556 citations

Regulatory role for hepatic low density lipoprotein receptors in vivo in the dog.

1981 • 424 citations

Interruption of the enterohepatic circulation of bile acids in man: comparative effects of cholestyramine and ileal exclusion on cholesterol metabolism.

1971 • 404 citations

Measurements of cholesterol turnover, synthesis, and absorption in man, carried out by isotope kinetic and sterol balance methods

1969 • 323 citations

Dietary β-sitosterol as an internal standard to correct for cholesterol losses in sterol balance studies

1968 • 265 citations

Effects of an Inhibitor of 3-Hydroxy-3-Methylglutaryl Coenzyme a Reductase on Serum Lipoproteins and Ubiquinone-10 Levels in Patients with Familial Hypercholesterolemia

1981 • 262 citations

Inhibition of Cholesterol Synthesis in vitro and in vivo by ML‐236A and ML‐236B, Competitive Inhibitors of 3‐Hydroxy‐3‐methylglutaryl‐Coenzyme A Reductase

1977 • 261 citations

Therapeutic effects of ML-236B in primary hypercholesterolemia

1980 • 231 citations

Cholesterol-lowering effect of mevinolin, an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme a reductase, in healthy volunteers.

1982 • 206 citations

Reduction of Serum Cholesterol in Heterozygous Patients with Familial Hypercholesterolemia

1983 • 201 citations

Usefulness of chromic oxide as an internal standard for balance studies in formula-fed patients and for assessment of colonic function

1968 • 195 citations

Inhibition of cholesterol synthesis with compactin renders growth of cultured cells dependent on the low density lipoprotein receptor.

1979 • 186 citations

Prediction of the parameters of whole body cholesterol metabolism in humans.

1980 • 96 citations

Receptor-mediated catabolism of homologous low density lipoproteins in cultured pig hepatocytes.

1981 • 94 citations

Ileal bypass in patients with hypercholesterolemia and atherosclerosis. Preliminary report on therapeutic potential.

1966 • 58 citations

Cholesterol and bile acid metabolism in moderately advanced, stable cirrhosis of the liver

1979 • 50 citations

Long-Term Kinetics of Serum and Xanthoma Cholesterol Radioactivity in Patients with Hypercholesterolemia

1972 • 43 citations