The Effect of CS-514 on Serum Lipids and Apolipoproteins in Hypercholesterolemic Subjects

Estimation of the Concentration of Low-Density Lipoprotein Cholesterol in Plasma, Without Use of the Preparative Ultracentrifuge

1972 • 31,801 citations

Enzymatic Determination of Total Serum Cholesterol

1974 • 9,182 citations

Rapid method for the isolation of lipoproteins from human serum by precipitation with polyanions

1970 • 2,523 citations

Serum Cholesterol, Lipoproteins, and the Risk of Coronary Heart Disease

1971 • 2,055 citations

CORONARY HEART DISEASE IN SEVEN COUNTRIES

1971 • 1,572 citations

ML-236A, ML-236B, and ML-236C, new inhibitors of cholesterogensis produced by Penicillium citrinum.

1976 • 926 citations

Serum Lipoproteins and Coronary Heart Disease in a Population Study of Hawaii Japanese Men

1976 • 889 citations

Competitive inhibition of 3‐hydroxy‐3‐methylglutaryl coenzyme a reductase by ML‐236A and ML‐236B fungal metabolites, having hypocholesterolemic activity

1976 • 788 citations

A Controlled Clinical Trial of a Diet High in Unsaturated Fat in Preventing Complications of Atherosclerosis

1969 • 600 citations

Mevinolin and colestipol stimulate receptor-mediated clearance of low density lipoprotein from plasma in familial hypercholesterolemia heterozygotes.

1983 • 562 citations

Regulatory role for hepatic low density lipoprotein receptors in vivo in the dog.

1981 • 424 citations

CS-514, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A reductase: tissue-selective inhibition of sterol synthesis and hypolipidemic effect on various animal species

1986 • 376 citations

Multilayer film elements for clinical analysis: applications to representative chemical determinations.

1978 • 355 citations

Feedback Regulation of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase in Livers of Mice Treated with Mevinolin, a Competitive Inhibitor of the Reductase

1980 • 305 citations

Effects of an Inhibitor of 3-Hydroxy-3-Methylglutaryl Coenzyme a Reductase on Serum Lipoproteins and Ubiquinone-10 Levels in Patients with Familial Hypercholesterolemia

1981 • 262 citations

Therapeutic effects of ML-236B in primary hypercholesterolemia

1980 • 231 citations

Influence of mevinolin on metabolism of low density lipoproteins in primary moderate hypercholesterolemia.

1985 • 210 citations

Historical Annotation

1969 • 207 citations

Cholesterol-lowering effect of mevinolin, an inhibitor of 3-hydroxy-3-methylglutaryl-coenzyme a reductase, in healthy volunteers.

1982 • 206 citations

Inhibition of cholesterol synthesis with compactin renders growth of cultured cells dependent on the low density lipoprotein receptor.

1979 • 186 citations

Therapeutic response to lovasatain (Mevinolin) in nonfamilial hypercholesterolemia - A Multicenter study

1986 • 175 citations

Simultaneous measurement of apolipoprotein B turnover in very-low- and low-density lipoproteins in familial hypercholesterolaemia

1977 • 157 citations

Quantitative studies of ver low densit lipoprotein: conversion to low densit lipoprotein in normal controls and primar hperlipidaemic states and the role of direct secretion of low densit lipoprotein in heterozgous familial hpercholesterolaemia

1980 • 146 citations

Relationship between plasma lipid concentrations and coronary artery disease in 496 patients.

1977 • 141 citations

The anti-coronary club. A dietary approach to the prevention of coronary heart disease--a seven-year report.

1966 • 140 citations

Hypolipidemic effects in dogs of ML-236B, a competitive inhibitor of 3-hydroxy-3-methylglutaryl coenzyme a reductase

1979 • 110 citations

Determination of B protein of low density lipoprotein directly in plasma.

1975 • 86 citations

Hypolipidemic effects in monkeys of ML‐236B, a competitive inhibitor of 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase

1979 • 81 citations

Mevinolin and cholestyramine inhibit the direct synthesis of low density lipoprotein apolipoprotein B in miniature pigs.

1985 • 77 citations

The Effect of CS-514, an Inhibitor of HMG-CoA Reductase, on Serum Lipids in Healthy Volunteers

1986 • 49 citations

Normal Cholesterol Levels With Lovastatin (Mevinolin) Therapy in a Child With Homozygous Familial Hypercholesterolemia Following Liver Transplantation

1986 • 45 citations

Blocking 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase with ML-236B Enhances the Plasma Cortisol Response to Adrenocorticotropin in Patients with Hypercholesterolemia

1984 • 11 citations