Imaging Features that Discriminate between Foci Induced by High- and Low-LET Radiation in Human Fibroblasts

DNA Double-stranded Breaks Induce Histone H2AX Phosphorylation on Serine 139

1998 • 5,093 citations

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

2003 • 3,385 citations

Megabase Chromatin Domains Involved in DNA Double-Strand Breaks in Vivo

1999 • 2,380 citations

A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage

2000 • 2,052 citations

ATM Phosphorylates Histone H2AX in Response to DNA Double-strand Breaks

2001 • 1,861 citations

Evidence for a lack of DNA double-strand break repair in human cells exposed to very low x-ray doses

2003 • 1,594 citations

Genomic Instability in Mice Lacking Histone H2AX

2002 • 1,343 citations

Dynamic Changes of BRCA1 Subnuclear Location and Phosphorylation State Are Initiated by DNA Damage

1997 • 910 citations

A Pathway of Double-Strand Break Rejoining Dependent upon ATM, Artemis, and Proteins Locating to γ-H2AX Foci

2004 • 819 citations

Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks

2004 • 750 citations

The Complexity of DNA Damage: Relevance to Biological Consequences

1994 • 604 citations

Nuclear foci of mammalian Rad51 recombination protein in somatic cells after DNA damage and its localization in synaptonemal complexes.

1995 • 556 citations

hMre11 and hRad50 Nuclear Foci Are Induced During the Normal Cellular Response to DNA Double-Strand Breaks †

1997 • 504 citations

DNA damage-induced activation of ATM and ATM-dependent signaling pathways

2004 • 472 citations

Dynamics of DNA Double-Strand Breaks Revealed by Clustering of Damaged Chromosome Domains

2004 • 466 citations

Phosphorylation of Histone H2AX and Activation of Mre11, Rad50, and Nbs1 in Response to Replication-dependent DNA Double-strand Breaks Induced by Mammalian DNA Topoisomerase I Cleavage Complexes

2003 • 444 citations

Nuclear foci of mammalian recombination proteins are located at single-stranded DNA regions formed after DNA damage

1999 • 348 citations

Expression of phosphorylated histone H2AX in cultured cell lines following exposure to X‐rays

2003 • 315 citations

Evidence for the organization of chromatin in megabase pair-sized loops arranged along a random walk path in the human G0/G1 interphase nucleus.

1995 • 284 citations

Cell Cycle-Dependent Expression of Phosphorylated Histone H2AX: Reduced Expression in Unirradiated but not X-Irradiated G₁-Phase Cells

2003 • 230 citations

Measurement of Prompt DNA Double-Strand Breaks in Mammalian Cells without Including Heat-Labile Sites: Results for Cells Deficient in Nonhomologous End Joining

2003 • 161 citations

Dephosphorylation of Histone γ-H2AX during Repair of DNA Double-Strand Breaks in Mammalian Cells and its Inhibition by Calyculin A

2003 • 135 citations

Measurement of Radiation-Induced DNA Double-Strand Breaks by Pulsed-Field Gel Electrophoresis

1990 • 108 citations

Focus Formation of DNA Repair Proteins in Normal and Repair-Deficient Cells Irradiated with High-LET Ions

2004 • 102 citations

Altered Regulation of Cyclin G in Human Breast Cancer and Its Specific Localization at Replication Foci in Response to DNA Damage in p53+/+ Cells

1999 • 89 citations

Localization and dynamic relocalization of mammalian Rad52 during the cell cycle and in response to DNA damage

1999 • 71 citations

Replication protein A and γ-H2AX foci assembly is triggered by cellular response to DNA double-strand breaks

2004 • 69 citations

Harmonic cut and regularized centroid transform for localization of subcellular structures

2003 • 63 citations

Dynamics of Relative Chromosome Position during the Cell Cycle

2004 • 62 citations

Chromatin Organization Contributes to Non-randomly Distributed Double-Strand Breaks after Exposure to High-LET Radiation

2004 • 60 citations

Hypertonic Saline Enhances Expression of Phosphorylated Histone H2AX after Irradiation

2004 • 24 citations

Large-Mutation Spectra Induced at Hemizygous Loci by Low-LET Radiation: Evidence for Intrachromosomal Proximity Effects

2001 • 15 citations