Ataxia Telangiectasia-mutated Protein Can Regulate p53 and Neuronal Death Independent of Chk2 in Response to DNA Damage

Pathobiology of ischaemic stroke: an integrated view

1999 • 3,776 citations

DNA Damage-Induced Phosphorylation of p53 Alleviates Inhibition by MDM2

1997 • 2,089 citations

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

1998 • 2,034 citations

Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

1998 • 1,734 citations

Chk1 is an essential kinase that is regulated by Atr and required for the G₂/M DNA damage checkpoint

2000 • 1,583 citations

DNA Damage-Induced Activation of p53 by the Checkpoint Kinase Chk2

2000 • 1,269 citations

p53AIP1, a Potential Mediator of p53-Dependent Apoptosis, and Its Regulation by Ser-46-Phosphorylated p53

2000 • 1,155 citations

The human homologs of checkpoint kinases Chk1 and Cds1 (Chk2) phosphorylate p53 at multiple DNA damage-inducible sites

2000 • 956 citations

DNA damage induces phosphorylation of the amino terminus of p53

1997 • 829 citations

Ataxia telangiectasia-mutated phosphorylates Chk2 in vivo and in vitro

2000 • 807 citations

ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

2001 • 681 citations

Essential role of BETA2/NeuroD1 in development of the vestibular and auditory systems

2000 • 620 citations

Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

1999 • 570 citations

Aberrant cell cycle checkpoint function and early embryonic death in Chk1^−/− mice

2000 • 466 citations

Rapid ATM-dependent phosphorylation of MDM2 precedes p53 accumulation in response to DNA damage

1999 • 449 citations

Serine15 phosphorylation stimulates p53 transactivation but does not directly influence interaction with HDM2

1999 • 446 citations

Requirement for Atm in Ionizing Radiation-Induced Cell Death in the Developing Central Nervous System

1998 • 425 citations

Replicating Huntington's disease phenotype in experimental animals

1999 • 410 citations

Chk2 Is a Tumor Suppressor That Regulates Apoptosis in both an Ataxia Telangiectasia Mutated (ATM)-Dependent and an ATM-Independent Manner

2002 • 393 citations

A potential role for apoptosis in neurodegeneration and Alzheimer's disease

1995 • 382 citations

Loss of the p53 tumor suppressor gene protects neurons from kainate- induced cell death

1996 • 378 citations

Poly(ADP-ribose) polymerase activation mediates 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced parkinsonism

1999 • 372 citations

Bax Involvement in p53-Mediated Neuronal Cell Death

1998 • 337 citations

Attenuation of p53 Expression Protects against Focal Ischemic Damage in Transgenic Mice

1994 • 317 citations

Threonine 68 is required for radiation-induced phosphorylation and activation of Cds1

2000 • 310 citations

Cyclin-dependent Kinases Participate in Death of Neurons Evoked by DNA-damaging Agents

1998 • 264 citations

p53 induction is associated with neuronal damage in the central nervous system.

1994 • 262 citations

Evidence for p53-Mediated Modulation of Neuronal Viability

1996 • 247 citations

The p53 pathway and apoptosis

1999 • 222 citations

E2F1 Mediates Death of B-amyloid-treated Cortical Neurons in a Manner Independent of p53 and Dependent on Bax and Caspase 3

2000 • 203 citations

APAF1 is a key transcriptional target for p53 in the regulation of neuronal cell death

2001 • 190 citations

Checkpoints: How to activate p53

2000 • 181 citations

Involvement of Retinoblastoma Family Members and E2F/DP Complexes in the Death of Neurons Evoked by DNA Damage

2000 • 151 citations

Cerebellar degeneration caused by high‐dose cytosine arabinoside: A clinicopathological study

1983 • 147 citations

Induction of CPP32-like Activity in PC12 Cells by Withdrawal of Trophic Support

1996 • 146 citations

Chk2 is dispensable for p53-mediated G₁arrest but is required for a latent p53-mediated apoptotic response

2002 • 140 citations

Dopamine Neurons from Transgenic Mice with a Knockout of the p53 Gene Resist MPTP Neurotoxicity

1996 • 135 citations

Contribution of p53-Dependent Caspase Activation to Neuronal Cell Death Declines with Neuronal Maturation

1999 • 111 citations

Mutation of Mouse p53 Ser23 and the Response to DNA Damage

2002 • 103 citations

Cyclin-Dependent Kinases and P53 Pathways Are Activated Independently and Mediate Bax Activation in Neurons after DNA Damage

2001 • 100 citations

Involvement of Caspase 3 in Apoptotic Death of Cortical Neurons Evoked by DNA Damage

2000 • 91 citations

Hippocampal Myc and p53 expression following transient global ischemia

1998 • 85 citations

Ataxia-telangiectasia and the ATM gene: Linking neurodegeneration, immunodeficiency, and cancer to cell cycle checkpoints

1996 • 80 citations

Critical roles for the serine 20, but not the serine 15, phosphorylation site and for the polyproline domain in regulating p53 turnover

2001 • 70 citations

Interaction of the c-Jun/JNK Pathway and Cyclin-dependent Kinases in Death of Embryonic Cortical Neurons Evoked by DNA Damage

2002 • 47 citations

Critical roles for the serine 20, but not the serine 15, phosphorylation site and for the polyproline domain in regulating p53 turnover

2001 • 43 citations

Filamentous degeneration of neurons. A possible feature of cytosine arabinoside neurotoxicity

1993 • 40 citations

Ataxia telangiectasia

1996 • 12 citations