How tissues respond to damage at the cellular level: orchestration by transforming growth factor-β (TGF-β)

TGF-β signaling in tumor suppression and cancer progression

2001 • 2,235 citations

Human transforming growth factor-β complementary DNA sequence and expression in normal and transformed cells

1985 • 1,687 citations

Controlling TGF-β signaling

2000 • 1,522 citations

Free Radicals in Biology: Oxidative Stress and the Effects of Ionizing Radiation

1994 • 1,396 citations

A Chemical Inhibitor of p53 That Protects Mice from the Side Effects of Cancer Therapy

1999 • 1,248 citations

Type beta transforming growth factor: a bifunctional regulator of cellular growth.

1985 • 1,107 citations

TGF-beta induced transdifferentiation of mammary epithelial cells to mesenchymal cells: involvement of type I receptors.

1994 • 937 citations

New class of transforming growth factors potentiated by epidermal growth factor: isolation from non-neoplastic tissues.

1981 • 925 citations

Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response

1999 • 912 citations

Cytokines in context.

1991 • 808 citations

Growth factors in development, transformation, and tumorigenesis

1991 • 695 citations

TGF-beta1 and Ha-Ras collaborate in modulating the phenotypic plasticity and invasiveness of epithelial tumor cells.

1996 • 680 citations

TGFβ signaling is necessary for carcinoma cell invasiveness and metastasis

1998 • 630 citations

TGF-β1 and radiation fibrosis: a master switch and a specific therapeutic target?

2000 • 626 citations

Control of scarring in adult wounds by neutralising antibody to transforming growth factor β

1992 • 624 citations

TGFβ1 Inhibits the Formation of Benign Skin Tumors, but Enhances Progression to Invasive Spindle Carcinomas in Transgenic Mice

1996 • 619 citations

The role of p53 in determining sensitivity to radiotherapy

2003 • 549 citations

Latent transforming growth factor-beta from human platelets. A high molecular weight complex containing precursor sequences.

1988 • 548 citations

Redox-mediated activation of latent transforming growth factor-beta 1.

1996 • 532 citations

Induction of alpha-smooth muscle actin by transforming growth factor-beta 1 in quiescent human breast gland fibroblasts. Implications for myofibroblast generation in breast neoplasia.

1993 • 511 citations

Maternal Rescue of Transforming Growth Factor-β 1 Null Mice

1994 • 494 citations

Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases

2002 • 490 citations

Transforming growth factor-beta activation in irradiated murine mammary gland.

1994 • 414 citations

Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases

2002 • 406 citations

Lifetime exposure to a soluble TGF-β antagonist protects mice against metastasis without adverse side effects

2002 • 375 citations

Lifetime exposure to a soluble TGF-β antagonist protects mice against metastasis without adverse side effects

2002 • 326 citations

Redox-mediated activation of latent transforming growth factor-beta 1

1996 • 245 citations

Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice

2004 • 231 citations

Latent transforming growth factor β1 activation in situ: quantitative and functional evidence after low‐dose γ‐irradiation ¹

1997 • 227 citations

Basic fibroblast growth factor-induced activation of latent transforming growth factor beta in endothelial cells: regulation of plasminogen activator activity.

1992 • 205 citations

How Do Tissues Respond to Damage at the Cellular Level? The Role of Cytokines in Irradiated Tissues

1998 • 191 citations

Interference with Transforming Growth Factor-β/ Smad3 Signaling Results in Accelerated Healing of Wounds in Previously Irradiated Skin

2003 • 165 citations

Radiotherapy in the management of giant cell tumor of bone

2003 • 162 citations

Latent Transforming Growth Factor-β Activation in Mammary Gland

2002 • 146 citations

Transforming growth factor-beta1 mediates cellular response to DNA damage in situ.

2002 • 141 citations

TGF-β antagonists: Why suppress a tumor suppressor?

2002 • 123 citations

Latency and activation in the control of TGF-β

1996 • 121 citations

Inducible expression of transforming growth factor beta1 in papillomas causes rapid metastasis.

2001 • 119 citations

Transforming growth factor beta 1 suppresses genomic instability independent of a G1 arrest, p53, and Rb.

1996 • 115 citations

TGF-β antagonists: Why suppress a tumor suppressor?

2002 • 106 citations

Blockade of Tumor Cell Transforming Growth Factor-βs Enhances Cell Cycle Progression and Sensitizes Human Breast Carcinoma Cells to Cytotoxic Chemotherapy

1998 • 84 citations

Hierarchical and cybernetic nature of biologic systems and their relevance to homeostatic adaptation to low-level exposures to oxidative stress-inducing agents.

1998 • 82 citations

Soluble TGFβ TYPE II receptor gene therapy ameliorates acute radiation-induced pulmonary injury in rats

2003 • 66 citations

Irradiated homozygous TGF- β 1 knockout fibroblasts show enhanced clonogenic survival as compared with TGF- β 1 wild-type fibroblasts

2002 • 32 citations

Increased Sensitivity of Transforming Growth Factor (TGF) β1 Null Cells to Alkylating Agents Reveals a Novel Link between TGFβ Signaling and O 6-Methylguanine Methyltransferase Promoter Hypermethylation

2001 • 28 citations

Reduced hematopoietic function and enhanced radiosensitivity of transforming growth factor-β1 transgenic mice

2000 • 14 citations

Overexpression of extracellular superoxide dismutase reduces severity of radiation-induced lung toxicity through downregulation of the TGF-β signal transduction pathway

2003 • 7 citations

BJR Supplement 27 Radiation‐Induced Multi‐Organ Involvement and Failure: A Challenge for Pathogenetic, Diagnostic and Therapeutic Approaches and Research

2006 • 6 citations