ATP Activates Ataxia-Telangiectasia Mutated (ATM) in Vitro

A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia

1992 • 3,092 citations

A Single Ataxia Telangiectasia Gene with a Product Similar to PI-3 Kinase

1995 • 2,767 citations

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

1998 • 2,034 citations

Cell cycle checkpoint signaling through the ATM and ATR kinases

2001 • 1,962 citations

Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

1998 • 1,734 citations

[11] Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates

1991 • 1,463 citations

BASC, a super complex of BRCA1-associated proteins involved in the recognition and repair of aberrant DNA structures

2000 • 1,236 citations

Inhibition of ATM and ATR kinase activities by the radiosensitizing agent, caffeine.

1999 • 1,032 citations

Phosphatidic Acid-Mediated Mitogenic Activation of mTOR Signaling

2001 • 1,012 citations

Requirement of ATM-Dependent Phosphorylation of Brca1 in the DNA Damage Response to Double-Strand Breaks

1999 • 1,005 citations

Ataxia telangiectasia: a human mutation with abnormal radiation sensitivity

1975 • 984 citations

Mammalian TOR: A Homeostatic ATP Sensor

2001 • 936 citations

Solubilization and Purification of Enzymatically Active Glutathione S-Transferase (pGEX) Fusion Proteins

1993 • 891 citations

ATM phosphorylates p95/nbs1 in an S-phase checkpoint pathway

2000 • 781 citations

ATM-dependent phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage

2001 • 681 citations

THE GENETIC DEFECT IN ATAXIA-TELANGIECTASIA

1997 • 637 citations

Phosphorylation of Ser-20 mediates stabilization of human p53 in response to DNA damage

1999 • 570 citations

Involvement of the cohesin protein, Smc1, in Atm-dependent and independent responses to DNA damage

2002 • 556 citations

Involvement of Brca1 in S-Phase and G₂-Phase Checkpoints after Ionizing Irradiation

2001 • 537 citations

ATM associates with and phosphorylates p53: mapping the region of interaction

1998 • 494 citations

Functional link between ataxia-telangiectasia and Nijmegen breakage syndrome gene products

2000 • 484 citations

SMC1 is a downstream effector in the ATM/NBS1 branch of the human S-phase checkpoint

2002 • 476 citations

ATM-dependent phosphorylation of nibrin in response to radiation exposure

2000 • 474 citations

Human cells contain a DNA-activated protein kinase that phosphorylates simian virus 40 T antigen, mouse p53, and the human Ku autoantigen.

1990 • 415 citations

The DNA damage-dependent intra–S phase checkpoint is regulated by parallel pathways

2002 • 383 citations

FKBP12-Rapamycin-associated Protein (FRAP) Autophosphorylates at Serine 2481 under Translationally Repressive Conditions

2000 • 338 citations

TAK1 Mediates the Ceramide Signaling to Stress-activated Protein Kinase/c-Jun N-terminal Kinase

1997 • 336 citations

ATM: Genome stability, neuronal development, and cancer cross paths

2001 • 304 citations

Foundations in Cancer Research p53 and ATM: Cell Cycle, Cell Death, and Cancer

1997 • 300 citations

On the Nature of a Defect in Cells from Individuals with Ataxia-Telangiectasia

1985 • 298 citations

Caffeine inhibits the checkpoint kinase ATM

1999 • 293 citations

The DNA-dependent Protein Kinase Is Inactivated by Autophosphorylation of the Catalytic Subunit

1996 • 287 citations

The Atr and Atm protein kinases associate with different sites along meiotically pairing chromosomes.

1996 • 282 citations

Nuclear Retention of ATM at Sites of DNA Double Strand Breaks

2001 • 275 citations

Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1

2000 • 274 citations

Radiation-induced Assembly of Rad51 and Rad52 Recombination Complex Requires ATM and c-Abl

1999 • 272 citations

TAK1 Mitogen-activated Protein Kinase Kinase Kinase Is Activated by Autophosphorylation within Its Activation Loop

2000 • 265 citations

Ataxia Telangiectasia

1967 • 259 citations

Binding of Inositol Phosphate to DNA-PK and Stimulation of Double-Strand Break Repair

2000 • 256 citations

Role for ATM in DNA damage-induced phosphorylation of BRCA1.

2000 • 247 citations

Identification of ataxia telangiectasia heterozygotes, a cancer prone population

1978 • 211 citations

Hypersensitivity of ataxia telangiectasia fibroblasts to ionizing radiation is associated with a repair deficiency of DNA double-strand breaks

1997 • 202 citations

Radiosensitivity in Ataxia-telangiectasia: Anomalies in Radiation-induced Cell Cycle Delay

1994 • 192 citations

Utilization of Oriented Peptide Libraries to Identify Substrate Motifs Selected by ATM

2000 • 190 citations

Localization of a Portion of Extranuclear ATM to Peroxisomes

1999 • 189 citations

The ataxia-telangiectasia gene product, a constitutively expressed nuclear protein that is not up-regulated following genome damage

1997 • 164 citations

Protein Phosphatases Regulate DNA-dependent Protein Kinase Activity

2001 • 157 citations

The Product of the ATM Gene Is a 370-kDa Nuclear Phosphoprotein

1996 • 131 citations

Purification and Characterization of ATM from Human Placenta

2000 • 122 citations

Functional Link between BLM Defective in Bloom's Syndrome and the Ataxia-telangiectasia-mutated Protein, ATM

2002 • 115 citations

The DNA-dependent protein kinase, DNA-PK: 10 years and no ends in sight

1996 • 115 citations

Hereditary neuropathies and spinocerebellar atrophies

1991 • 107 citations

ATP-dependent Activation of the Intermediate Conductance, Ca2+-activated K+ Channel, hIK1, Is Conferred by a C-terminal Domain

2001 • 103 citations

Nature of G1/S cell cycle checkpoint defect in ataxia-telangiectasia.

1995 • 89 citations

Regulation of the activity of MEK kinase 1 (MEKK1) by autophosphorylation within the kinase activation domain

1997 • 71 citations

Structures of Unliganded and ATP-Bound States of the Escherichia coli Chaperonin GroEL by Cryoelectron Microscopy

2001 • 43 citations

Autoactivation of calmodulin-dependent protein kinase II by autophosphorylation.

1991 • 32 citations

Transcriptional downregulation of ATM by EGF is defective in ataxia-telangiectasia cells expressing mutant protein

2001 • 25 citations

Identification by mass spectrometry of the phosphorylated residue responsible for activation of the catalytic domain of myosin I heavy chain kinase, a member of the PAK/STE20 family

1997 • 25 citations

Conformational Diversity of Catalytic Cores of Protein Kinases

1999 • 23 citations

Cloning and Expression of the Ataxia–Telangiectasia Gene in Baculovirus

1998 • 17 citations