TGF-β signaling in vascular fibrosis

Smad-dependent and Smad-independent pathways in TGF-β family signalling

2003 • 5,052 citations

Rho GTPases and signaling networks

1997 • 2,380 citations

Smad transcription factors

2005 • 2,366 citations

TGF‐β signaling and the fibrotic response

2004 • 2,195 citations

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

1993 • 1,941 citations

Direct binding of Smad3 and Smad4 to critical TGFbeta -inducible elements in the promoter of human plasminogen activator inhibitor-type 1gene

1998 • 1,763 citations

Losartan, an AT1 Antagonist, Prevents Aortic Aneurysm in a Mouse Model of Marfan Syndrome

2006 • 1,697 citations

Making sense of latent TGFβ activation

2002 • 1,579 citations

Aneurysm Syndromes Caused by Mutations in the TGF-β Receptor

2006 • 1,558 citations

Connective-tissue growth factor (CTGF) modulates cell signalling by BMP and TGF-β

2002 • 866 citations

Connective tissue growth factor coordinates chondrogenesis and angiogenesis during skeletal development

2003 • 702 citations

CCN proteins: multifunctional signalling regulators

2004 • 692 citations

Smad3 Mutant Mice Develop Metastatic Colorectal Cancer

1998 • 677 citations

Vascular smooth muscle cell hypertrophy vs. hyperplasia. Autocrine transforming growth factor-beta 1 expression determines growth response to angiotensin II.

1992 • 648 citations

Transforming Growth Factor-β Signaling Through the Smad Pathway: Role in Extracellular Matrix Gene Expression and Regulation

2002 • 622 citations

Smad2 role in mesoderm formation, left–right patterning and craniofacial development

1998 • 600 citations

Redox signaling in hypertension

2006 • 560 citations

Mechanisms of TGF-β signaling in regulation of cell growth and differentiation

2002 • 521 citations

TGF-? receptor function in the endothelium

2004 • 502 citations

Fibrosis in heart disease: understanding the role of transforming growth factor‐β₁ in cardiomyopathy, valvular disease and arrhythmia

2006 • 479 citations

CTGF Expression is Induced by TGF- β in Cardiac Fibroblasts and Cardiac Myocytes: a Potential Role in Heart Fibrosis

2000 • 430 citations

Transforming growth factor-β1 induces Nox4 NAD(P)H oxidase and reactive oxygen species-dependent proliferation in human pulmonary artery smooth muscle cells

2005 • 387 citations

Vascular Smooth Muscle Growth: Autocrine Growth Mechanisms

2001 • 383 citations

Cross‐talk between ERK MAP kinase and Smad‐signaling pathways enhances TGF‐β dependent responses in human mesangial cells

2003 • 359 citations

Angiotensin II: a key factor in the inflammatory and fibrotic response in kidney diseases

2005 • 335 citations

Angiotensin II Activates the Smad Pathway in Vascular Smooth Muscle Cells by a Transforming Growth Factor-β–Independent Mechanism

2005 • 314 citations

Human Connective Tissue Growth Factor Is Expressed in Advanced Atherosclerotic Lesions

1997 • 301 citations

Emilin1 Links TGF-β Maturation to Blood Pressure Homeostasis

2006 • 280 citations

Transforming Growth Factor β and Atherosclerosis: So Far, So Good for the Protective Cytokine Hypothesis

2003 • 276 citations

Connective Tissue Growth Factor Is a Mediator of Angiotensin II–Induced Fibrosis

2003 • 264 citations

Advanced glycation end products activate Smad signaling via TGF‐β‐dependent and ‐independent mechanisms: implications for diabetic renal and vascular disease

2003 • 254 citations

Matrix Metalloproteinase 2 Activation of Transforming Growth Factor-β1 (TGF-β1) and TGF-β1–Type II Receptor Signaling Within the Aged Arterial Wall

2006 • 241 citations

Essential Role of Smad3 in Angiotensin II–Induced Vascular Fibrosis

2006 • 234 citations

Hierarchical model of gene regulation by transforming growth factor β

2003 • 209 citations

Important Role of Rho-kinase in the Pathogenesis of Cardiovascular Inflammation and Remodeling Induced by Long-Term Blockade of Nitric Oxide Synthesis in Rats

2002 • 195 citations

Interaction of Smad3 with a proximal smad-binding element of the human ?2(I) procollagen gene promoter required for transcriptional activation by TGF-?

2000 • 180 citations

Mammalian transforming growth factor-βs: Smad signaling and physio-pathological roles

2003 • 177 citations

Interaction between angiotensin II and Smad proteins in fibroblasts in failing heart and in vitro

2000 • 171 citations

Endoglin: An accessory component of the TGF‐β‐binding receptor‐complex with diagnostic, prognostic, and bioimmunotherapeutic potential in human malignancies

2001 • 171 citations

Smad pathway is activated in the diabetic mouse kidney and Smad3 mediates TGF-β-induced fibronectin in mesangial cells

2002 • 167 citations

Molecular mechanisms of angiotensin II-induced vascular injury

2003 • 161 citations

The complex pattern of SMAD signaling in the cardiovascular system☆

2005 • 159 citations

Angiotensin II induces thrombospondin-1 production in human mesangial cells via p38 MAPK and JNK: a mechanism for activation of latent TGF-β₁

2004 • 153 citations

Escaping from the TGF anti-proliferative control

2006 • 148 citations

Role of TGF-β signaling in extracellular matrix production under high glucose conditions

2003 • 148 citations

RhoA Modulates Smad Signaling during Transforming Growth Factor-β-induced Smooth Muscle Differentiation

2005 • 146 citations

TGF-β signaling from receptors to the nucleus

1999 • 141 citations

δEF1 Mediates TGF-β Signaling in Vascular Smooth Muscle Cell Differentiation

2006 • 140 citations

TGF-β and atherosclerosis in man

2007 • 139 citations

Overexpression of Transforming Growth Factor-β1 Stabilizes Already-Formed Aortic Aneurysms

2005 • 137 citations

Connective tissue growth factor (CTGF) stimulates vascular smooth muscle cell growth and migration in vitro

2000 • 127 citations

Transforming Growth Factor-β1-induced Expression of Smooth Muscle Marker Genes Involves Activation of PKN and p38 MAPK

2005 • 124 citations

Endothelin-1, via ET _A Receptor and Independently of Transforming Growth Factor-β, Increases the Connective Tissue Growth Factor in Vascular Smooth Muscle Cells

2005 • 118 citations

Growth Inhibition by Insulin-like Growth Factor-binding Protein-3 in T47D Breast Cancer Cells Requires Transforming Growth Factor-β (TGF-β) and the Type II TGF-β Receptor

2000 • 113 citations

Angiotensin II induces human TGF-β1 promoter activation: similarity to hyperglycaemia

2002 • 109 citations

Reactive oxygen species mediate TGF-β1-induced plasminogen activator inhibitor-1 upregulation in mesangial cells

2003 • 105 citations

Nonoverlapping expression patterns of ALK1 and ALK5 reveal distinct roles of each receptor in vascular development

2005 • 105 citations

Endoglin Structure and Function

2006 • 101 citations

Transforming Growth Factor-β-Dependent Growth Inhibition in Primary Vascular Smooth Muscle Cells Is p38-Dependent

2005 • 100 citations

Smad Expression in Human Atherosclerotic Lesions

2004 • 99 citations

Transforming Growth Factor-Beta-Dependent Events in Vascular Remodeling following Arterial Injury

2003 • 96 citations

Modulation of the TGFβ/Smad signaling pathway in mesangial cells by CTGF/CCN2

2005 • 91 citations

Fasudil, a Rho-kinase inhibitor, attenuates glomerulosclerosis in Dahl salt-sensitive rats

2004 • 85 citations

Hydrogen peroxide-mediated transcriptional induction of macrophage colony-stimulating factor by TGF-beta1.

1997 • 78 citations

Targeted Disruption of TGF-β–Smad3 Signaling Leads to Enhanced Neointimal Hyperplasia With Diminished Matrix Deposition in Response to Vascular Injury

2005 • 73 citations

Smad7: a new key player in TGF-β-associated disease

2002 • 58 citations

Minireview: Inhibin Binding Protein (InhBP/p120), Betaglycan, and the Continuing Search for the Inhibin Receptor

2002 • 57 citations

Plasminogen activator inhibitor type‐1 gene expression and induced migration in TGF‐β1‐stimulated smooth muscle cells is pp60^c‐src/MEK‐dependent

2004 • 57 citations

Smad7 Gene Transfer Attenuates Adventitial Cell Migration and Vascular Remodeling After Balloon Injury

2005 • 57 citations

The Rho-kinase pathway regulates angiotensin II-induced renal damage

2005 • 56 citations

The 26S proteasome system in the signaling pathways of TGF-BETA superfamily

2003 • 50 citations

Activin Receptor-Like Kinases: Structure, Function and Clinical Implications

2006 • 49 citations

PKCδ Is Necessary for Smad3 Expression and Transforming Growth Factor β–Induced Fibronectin Synthesis in Vascular Smooth Muscle Cells

2006 • 46 citations

Regulation of matrix proteins and impact on vascular structure

2000 • 42 citations

Smad protein and TGF-β signaling in vascular smooth muscle cells

2003 • 42 citations

Oxidized LDL activates PAI-1 transcription through autocrine activation of TGF-β signaling in mesangial cells

2005 • 40 citations

Nerve growth factor mediates activation of the Smad pathway in PC12 cells

2004 • 39 citations

CYCLOSPORINE INDUCES MYOCARDIAL CONNECTIVE TISSUE GROWTH FACTOR IN SPONTANEOUSLY HYPERTENSIVE RATS ON HIGH-SODIUM DIET1

2001 • 38 citations

AT_1A-mediated activation of kidney JNK1 and SMAD2 in obstructive uropathy: preservation of kidney tissue mass using candesartan

2004 • 26 citations

Roles of RhoA and Phospholipase A2 in the Elevation of Intracellular H2O2 by Transforming Growth Factor-β in Swiss 3T3 Fibroblasts

1999 • 23 citations

Smad6s Regulates Plasminogen Activator Inhibitor-1 through a Protein Kinase C-β-dependent Up-regulation of Transforming Growth Factor-β

2005 • 20 citations

Increased mRNA Expression of Transforming Growth Factor Beta in the Arterial Wall of Chronically Rejected Renal Allografts in Humans

2006 • 7 citations

Angiotensin ii causes epithelial mesenchymal transdifferentiation via activation of smad and mapk signaling pathways

2006 • 1 citations