Growth Inhibition by Insulin-like Growth Factor-binding Protein-3 in T47D Breast Cancer Cells Requires Transforming Growth Factor-β (TGF-β) and the Type II TGF-β Receptor

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

TGF-β signalling from cell membrane to nucleus through SMAD proteins

1997 • 3,650 citations

The Transforming Growth Factor-beta Family

1990 • 3,028 citations

DPC4 , A Candidate Tumor Suppressor Gene at Human Chromosome 18q21.1

1996 • 2,320 citations

Identification of Smad7, a TGFβ-inducible antagonist of TGF-β signalling

1997 • 1,774 citations

Type beta transforming growth factor: a bifunctional regulator of cellular growth.

1985 • 1,107 citations

Smad6 inhibits signalling by the TGF-β superfamily

1997 • 1,026 citations

TGF-beta receptor-mediated signalling through Smad2, Smad3 and Smad4

1997 • 1,023 citations

Evidence that transforming growth factor-β is a hormonally regulated negative growth factor in human breast cancer cells

1987 • 998 citations

TGF-β stimulation and inhibition of cell proliferation: New mechanistic insights

1990 • 992 citations

Partnership between DPC4 and SMAD proteins in TGF-β signalling pathways

1996 • 899 citations

Induction of the growth inhibitor IGF-binding protein 3 by p53

1995 • 884 citations

TGFβ Signaling: Receptors, Transducers, and Mad Proteins

1996 • 840 citations

Insulin-like Growth Factor (IGF)-binding Protein-3 Induces Apoptosis and Mediates the Effects of Transforming Growth Factor-β1 on Programmed Cell Death through a p53- and IGF-independent Mechanism

1997 • 725 citations

The TGF-beta family mediator Smad1 is phosphorylated directly and activated functionally by the BMP receptor kinase.

1997 • 569 citations

Binding proteins for the insulin-like growth factors: Structure, regulation and function

1989 • 565 citations

Distribution and modulation of the cellular receptor for transforming growth factor-beta.

1987 • 556 citations

Growth hormone-dependent insulin-like growth factor (IGF) binding protein both inhibits and potentiates IGF-I-stimulated DNA synthesis in human skin fibroblasts

1988 • 488 citations

Insulin-like growth factor (IGF)-independent action of IGF-binding protein-3 in Hs578T human breast cancer cells. Cell surface binding and growth inhibition

1993 • 481 citations

Genetic changes in the transforming growth factor beta (TGF-beta) type II receptor gene in human gastric cancer cells: correlation with sensitivity to growth inhibition by TGF-beta.

1994 • 431 citations

Phosphorylation of Ser465 and Ser467 in the C Terminus of Smad2 Mediates Interaction with Smad4 and Is Required for Transforming Growth Factor-β Signaling

1997 • 383 citations

Cloning and Expression of the Growth Hormone-Dependent Insulin-Like Growth Factor-Binding Protein

1988 • 367 citations

Insulin-Like Growth Factor Binding Proteins in the Human Circulation: A Review

1994 • 346 citations

Insulin-like growth factor-binding protein from human plasma. Purification and characterization.

1986 • 343 citations

Expression of transforming growth factor beta type II receptor leads to reduced malignancy in human breast cancer MCF-7 cells

1994 • 325 citations

Demonstration of receptors for insulin-like growth factor binding protein-3 on Hs578T human breast cancer cells.

1993 • 317 citations

The Type V Transforming Growth Factor β Receptor Is the Putative Insulin-like Growth Factor-binding Protein 3 Receptor

1997 • 259 citations

Insulin-like growth factor binding protein 3 mediates retinoic acid- and transforming growth factor beta2-induced growth inhibition in human breast cancer cells.

1996 • 257 citations

Transforming Growth Factor β: Biochemistry and Roles in Embryogenesis, Tissue Repair and Remodeling, and Carcinogenesis

1988 • 255 citations

Transforming growth factor beta: potential autocrine growth inhibitor of estrogen receptor-negative human breast cancer cells.

1988 • 247 citations

β-Transforming Growth Factor is stored in human blood platelets as a latent high molecular weight complex

1986 • 241 citations

Transforming Growth Factor- β-induced Cell Growth Inhibition in Human Breast Cancer Cells Is Mediated through Insulin-like Growth Factor-binding Protein-3 Action

1995 • 241 citations

The transforming growth factor-beta receptor type III is a membrane proteoglycan. Domain structure of the receptor.

1988 • 240 citations

Resistance to inhibition of cell growth by transforming growth factor-beta and its role in oncogenesis.

1993 • 239 citations

Estradiol and Antiestrogens Regulate a Growth Inhibitory Insulin-like Growth Factor Binding Protein 3 Autocrine Loop in Human Breast Cancer Cells

1996 • 225 citations

Specific binding to cultured cells of 125I-labeled type beta transforming growth factor from human platelets.

1984 • 212 citations

Heteromeric and Homomeric Interactions Correlate with Signaling Activity and Functional Cooperativity of Smad3 and Smad4/DPC4

1997 • 207 citations

Genetic change in transforming growth factor beta (TGF-beta) receptor type I gene correlates with insensitivity to TGF-beta 1 in human prostate cancer cells.

1996 • 195 citations

Regulation of transforming growth factor β- and activin-induced transcription by mammalian Mad proteins

1996 • 162 citations

Transfection of the human insulin-like growth factor binding protein-3 gene into Balb/c fibroblasts inhibits cellular growth.

1993 • 160 citations

Resistance to transforming growth factor beta and activin due to reduced receptor expression in human breast tumor cell lines.

1995 • 155 citations

Insulin‐like growth factor‐binding protein enhancement of insulin‐like growth factor‐i (IGF‐I)–mediated DNA synthesis and IGF‐I binding in a human breast carcinoma cell line

1994 • 154 citations

Growth inhibition of both MCF-7 and Hs578T human breast cancer cell lines by vitamin D analogues is associated with increased expression of insulin-like growth factor binding protein-3

1998 • 144 citations

Reduced Expression of Transforming Growth Factor β Type I Receptor Contributes to the Malignancy of Human Colon Carcinoma Cells

1996 • 122 citations

Estrogen and antiestrogen modulation of MCF7 human breast cancer cell proliferation is associated with specific alterations in accumulation of insulin-like growth factor-binding proteins in conditioned media.

1993 • 120 citations

Latent beta-transforming growth factor in nontransformed and Kirsten sarcoma virus-transformed normal rat kidney cells, clone 49F.

1984 • 112 citations

Attenuated ALK5 receptor expression in human pancreatic cancer: Correlation with resistance to growth inhibition

1996 • 107 citations

Interactions of High Affinity Insulin-like Growth Factor-binding Proteins with the Type V Transforming Growth Factor-β Receptor in Mink Lung Epithelial Cells

1999 • 107 citations

A surface component on GH3 pituitary cells that recognizes transforming growth factor-beta, activin, and inhibin.

1988 • 103 citations

Production of and responsiveness to transforming growth factor-beta in normal and oncogene-transformed human mammary epithelial cells.

1989 • 102 citations

Insulin-like growth factor-binding protein-3 production by MCF-7 breast cancer cells: stimulation by retinoic acid and cyclic adenosine monophosphate and differential effects of estradiol.

1995 • 101 citations

Regulation of Transforming Growth Factor α and Transforming Growth Factor β Messenger Ribonucleic Acid Abundance in T-47D, Human Breast Cancer Cells

1989 • 97 citations

Insulin-like Growth Factor Binding Protein 3 (IGF-BP3) Inhibits Estrogen-Stimulated Breast Cancer Cell Proliferation

1994 • 71 citations

Oncogenic ras Causes Resistance to the Growth Inhibitor Insulin-like Growth Factor Binding Protein-3 (IGFBP-3) in Breast Cancer Cells

1999 • 67 citations

Frequent inactivation of the transforming growth factor beta type II receptor in small-cell lung carcinoma cells.

1997 • 58 citations

Interaction of growth factors during progression towards steroid independence in T‐47‐D human breast cancer cells

1990 • 56 citations

Development of Resistance to Insulin-like Growth Factor Binding Protein-3 in Transfected T47D Breast Cancer Cells

1998 • 46 citations

Production of an Insulin-Like Growth Factor (IGF)- Inducible IGF-Binding Protein by Human Skin Fibroblasts*

1990 • 43 citations

Transforming growth factor-beta receptors in human cancer cell lines: analysis of transcript, protein and proliferation.

1997 • 43 citations

Expression profile of agonistic Smads in human breast cancer cells: Absence of regulation by estrogens

1999 • 39 citations

Roles for transforming growth factors-β in the genesis, prevention, and treatment of breast cancer

1991 • 37 citations

Expression of transforming growth factor-β receptor type II and tumorigenicity in human breast adenocarcinoma MCF-7 cells

1998 • 30 citations

PROTEINS IN TISSUE EXTRACTS WHICH BIND INSULIN-LIKE GROWTH FACTOR BINDING PROTEIN-3 (IGFBP-3)

1995 • 23 citations

Differential Regulation of Insulin-Like Growth Factor-Binding Protein-3 Protease Activity in MCF-7 Breast Cancer Cells by Estrogen and Transforming Growth Factor-β1*

2000 • 15 citations

Postsynthetic regulation of insulin-like growth factor-binding protein-3 by MCF-7 human breast cancer cells in culture

1996 • 5 citations