Smad6s Regulates Plasminogen Activator Inhibitor-1 through a Protein Kinase C-β-dependent Up-regulation of Transforming Growth Factor-β

Heart-Lung Transplantation

2016 • 2,165 citations

NEW EMBO MEMBERS REVIEW: Transcriptional control by the TGF-beta/Smad signaling system

2000 • 1,935 citations

Direct binding of Smad3 and Smad4 to critical TGFbeta -inducible elements in the promoter of human plasminogen activator inhibitor-type 1gene

1998 • 1,763 citations

TGFβ signals through a heteromeric protein kinase receptor complex

1992 • 1,519 citations

The MAD-Related Protein Smad7 Associates with the TGFβ Receptor and Functions as an Antagonist of TGFβ Signaling

1997 • 1,328 citations

Smad6 inhibits signalling by the TGF-β superfamily

1997 • 1,026 citations

Vascular-Bed–Specific Hemostasis and Hypercoagulable States

1999 • 575 citations

Characterization of protein kinase C beta isoform activation on the gene expression of transforming growth factor-beta, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats.

1997 • 532 citations

Smads as transcriptional co-modulators

2000 • 522 citations

Essential role of stromal mesenchyme in kidney morphogenesis revealed by targeted disruption of Winged Helix transcription factor BF-2.

1996 • 493 citations

A role for Smad6 in development and homeostasis of the cardiovascular system

2000 • 488 citations

Amelioration of accelerated diabetic mesangial expansion by treatment with a PKC β inhibitor in diabetic db/db mice, a rodent model for type 2 diabetes

2000 • 425 citations

Antisense Gene Inhibition by Oligonucleotides Containing C-5 Propyne Pyrimidines

1993 • 405 citations

Characterization of the Promoter Region of the Human Transforming Growth Factor-β1 Gene

1989 • 400 citations

Coagulation, fibrinolysis, and fibrin deposition in acute lung injury

2003 • 359 citations

Induction of Inhibitory Smad6 and Smad7 mRNA by TGF-β Family Members

1998 • 355 citations

Identification of regulatory sequences in the type 1 plasminogen activator inhibitor gene responsive to transforming growth factor beta.

1991 • 324 citations

Derangements of Coagulation and Fibrinolysis in Critically III Patients with Sepsis and Septic Shock

1998 • 300 citations

Regulation of Type 1 Plasminogen Activator Inhibitor Gene Expression in Cultured Bovine Aortic Endothelial Cells

1989 • 248 citations

Variation in plasminogen-activator-inhibitor-1 gene and risk of meningococcal septic shock

1999 • 217 citations

Induction of Smad6 mRNA by Bone Morphogenetic Proteins

1998 • 168 citations

Modulation of transforming growth factor beta receptor levels on microvascular endothelial cells during in vitro angiogenesis.

1996 • 161 citations

Multiple transforming growth factor-beta-inducible elements regulate expression of the plasminogen activator inhibitor type-1 gene in Hep G2 cells.

1991 • 158 citations

Distinct Patterns of Transforming Growth Factor-β Isoform and Receptor Expression in Human Atherosclerotic Lesions

1999 • 156 citations

Regulation of the PAI-1 promoter by circadian clock components: differential activation by BMAL1 and BMAL2

2003 • 155 citations

Assignment of Transforming Growth Factor β1 and β3 and a Third New Ligand to the Type I Receptor ALK-1

1999 • 144 citations

Smad4/DPC4 and Smad3 Mediate Transforming Growth Factor-β (TGF-β) Signaling through Direct Binding to a Novel TGF-β-responsive Element in the Human Plasminogen Activator Inhibitor-1 Promoter

1998 • 138 citations

The PAI-1 Gene Locus 4G/5G Polymorphism Is Associated With a Family History of Coronary Artery Disease

1998 • 132 citations

Tumor Necrosis Factor α Activates the Human Plasminogen Activator Inhibitor-1 Gene through a Distal Nuclear Factor κB Site

2004 • 128 citations

Structural and functional characterization of the transforming growth factor beta 3 promoter. A cAMP-responsive element regulates basal and induced transcription.

1990 • 124 citations

TGF-βs and TGF-β receptors in atherosclerosis

2000 • 122 citations

Smad6 functions as an intracellular antagonist of some TGF‐β family members during Xenopus embryogenesis

1998 • 78 citations

Plasminogen Activator Inhibitor 1, Fibrin, and the Vascular Response to Injury

2004 • 49 citations

The Renin-Angiotensin-Aldosterone System and Fibrinolysis in Progressive Renal Disease

2002 • 47 citations

Regulation of urokinase plasminogen activator/plasmin‐ mediated invasion of melanoma cells by the integrin vitronectin receptor αVβ3

2001 • 44 citations

Upregulation of PAI-1 is mediated through TGF-β/Smad pathway in transplant arteriopathy

2002 • 44 citations

Identification of a cis-Acting Sequence in the Human Plasminogen Activator Inhibitor Type-1 Gene That Mediates Transforming Growth Factor-β1 Responsiveness in Endothelium in Vivo

1996 • 43 citations

Xenopus brain factor-2 controls mesoderm, forebrain and neural crest development

1999 • 41 citations

Differential Mechanisms of Plasminogen Activator Inhibitor-1 Gene Activation by Transforming Growth Factor-β and Tumor Necrosis Factor-α in Endothelial Cells

2001 • 40 citations

Plasminogen activator inhibitor type-1: Its structure, biological activity and role in tumorigenesis (Review)

2004 • 38 citations

Modulation of Thrombomodulin-dependent Activation of Human Protein C through Differential Expression of Endothelial Smads

2002 • 32 citations

Cigarette smoke concentrate increases 8-epi-PGF2$alpha; and TGF$beta;1 secretion in rat mesangial cells

2004 • 32 citations

A novel protein interacts with the major transforming growth factor-beta responsive element in the plasminogen activator inhibitor type-1 gene.

1994 • 31 citations

The Kidney-expressed Winged Helix Transcription Factor FREAC-4 Is Regulated by Ets-1

1999 • 29 citations

Activation of the adenovirus and BK virus late promoters: effects of the BK virus enhancer and trans-acting viral early proteins.

1986 • 29 citations

Characterization of the Human Forkhead Gene FREAC-4

1996 • 28 citations

A new role for the stromal cells in kidney development

1996 • 24 citations

Activation of Plasminogen Activator Inhibitor-1 Synthesis by Phorbol Esters in Human Promyelocyte HL-60

1999 • 23 citations

Regulation of plasminogen activation by TGF-beta in cultured human retinal endothelial cells

2000 • 19 citations

17β-Estradiol, But Not Raloxifene, Decreases Thrombomodulin in the Antithrombotic Protein C Pathway

2000 • 18 citations

Antisense targeting of c-fos transcripts inhibits serum- and TGF-?1-stimulated PAI-1 gene expression and directed motility in renal epithelial cells

2001 • 16 citations

Repression of enhancer activity by the adenovirus E1A tumor protein(s) is mediated through a novel HeLa cell nuclear factor

1991 • 13 citations

Regulation of urokinase plasminogen activator/plasmin- mediated invasion of melanoma cells by the integrin vitronectin receptor α_Vβ₃

2000 • 12 citations

Human truncated Smad 6 (Smad 6s) inhibits the BMP pathway in Xenopus laevis

2001 • 9 citations

Mechanisms leading to progression of chronic renal injury: the interstitium

2004 • 4 citations