The Rho-kinase pathway regulates angiotensin II-induced renal damage

Calcium sensitization of smooth muscle mediated by a Rho-associated protein kinase in hypertension

1997 • 2,847 citations

Formation of Actin Stress Fibers and Focal Adhesions Enhanced by Rho-Kinase

1997 • 1,085 citations

Regulation of the Cytoskeleton and Cell Adhesion by the Rho Family GTPases in Mammalian Cells

1999 • 1,015 citations

Pharmacological properties of Y-27632, a specific inhibitor of rho-associated kinases.

2000 • 900 citations

Ras and Rho GTPases

2000 • 779 citations

CCN proteins: multifunctional signalling regulators

2004 • 692 citations

Rho-associated Kinase Directly Induces Smooth Muscle Contraction through Myosin Light Chain Phosphorylation

1997 • 576 citations

Renal injury from angiotensin II-mediated hypertension.

1992 • 546 citations

Angiotensin II and Renal Fibrosis

2001 • 503 citations

Transcription factor-κB (NF-κB) and renal disease

2001 • 474 citations

Angiotensin II regulates the synthesis of proinflammatory cytokines and chemokines in the kidney

2002 • 411 citations

Proinflammatory actions of angiotensins

2001 • 409 citations

Activation of RhoA and Inhibition of Myosin Phosphatase as Important Components in Hypertension in Vascular Smooth Muscle

2003 • 324 citations

Phosphorylation of Adducin by Rho-Kinase Plays a Crucial Role in Cell Motility

1999 • 300 citations

Connective tissue growth factor: Potential role in glomerulosclerosis and tubulointerstitial fibrosis

2000 • 290 citations

Renoprotective effects of angiotensin II receptor blockade in type 1 diabetic patients with diabetic nephropathy

2000 • 285 citations

Angiotensin II participates in mononuclear cell recruitment in experimental immune complex nephritis through nuclear factor-kappa B activation and monocyte chemoattractant protein-1 synthesis.

1998 • 285 citations

Involvement of Rho-kinase in hypertensive vascular disease: a novel therapeutic target in hypertension

2001 • 281 citations

Connective Tissue Growth Factor Is a Mediator of Angiotensin II–Induced Fibrosis

2003 • 264 citations

Angiotensin II stimulates expression of the chemokine RANTES in rat glomerular endothelial cells. Role of the angiotensin type 2 receptor.

1997 • 255 citations

Multiple Signalling Pathways Lead to the Activation of the Nuclear Factor κB by the Rho Family of GTPases

1998 • 233 citations

Angiotensin II Participates in Mononuclear Cell Recruitment in Experimental Immune Complex Nephritis Through Nuclear Factor-κB Activation and Monocyte Chemoattractant Protein-1 Synthesis

1998 • 226 citations

Angiotensin II Activates RhoA in Cardiac Myocytes

1998 • 224 citations

Y-27632 prevents tubulointerstitial fibrosis in mouse kidneys with unilateral ureteral obstruction

2002 • 210 citations

Important Role of Rho-kinase in the Pathogenesis of Cardiovascular Inflammation and Remodeling Induced by Long-Term Blockade of Nitric Oxide Synthesis in Rats

2002 • 195 citations

Systemic Infusion of Angiotensin II into Normal Rats Activates Nuclear Factor-κB and AP-1 in the Kidney

2001 • 180 citations

Involvement of Rho-Kinase in Angiotensin II–Induced Hypertrophy of Rat Vascular Smooth Muscle Cells

2000 • 177 citations

Rho-Kinase Mediates Angiotensin II-Induced Monocyte Chemoattractant Protein-1 Expression in Rat Vascular Smooth Muscle Cells

2001 • 176 citations

Peroxisome Proliferator-activated Receptor γ Inhibits Transforming Growth Factor β-induced Connective Tissue Growth Factor Expression in Human Aortic Smooth Muscle Cells by Interfering with Smad3

2001 • 173 citations

Roles of Rho-associated Kinase in Cytokinesis; Mutations in Rho-associated Kinase Phosphorylation Sites Impair Cytokinetic Segregation of Glial Filaments

1998 • 164 citations

Molecular mechanisms of angiotensin II-induced vascular injury

2003 • 161 citations

Critical Role of Rho-Kinase and MEK/ERK Pathways for Angiotensin II–Induced Plasminogen Activator Inhibitor Type-1 Gene Expression

2001 • 143 citations

Expression of Connective Tissue Growth Factor in Human Renal Fibroblasts

2001 • 130 citations

Angiotensin II Increases Connective Tissue Growth Factor in the Kidney

2003 • 109 citations

Effect of fasudil on Rho-kinase and nephropathy in subtotally nephrectomized spontaneously hypertensive rats

2003 • 96 citations

Fasudil, a Rho-kinase inhibitor, attenuates glomerulosclerosis in Dahl salt-sensitive rats

2004 • 85 citations

Fasudil attenuates interstitial fibrosis in rat kidneys with unilateral ureteral obstruction

2002 • 81 citations

Involvement of Rho-Kinase and the Actin Filament Network in Angiotensin II–Induced Contraction and Extracellular Signal–Regulated Kinase Activity in Intact Rat Mesenteric Resistance Arteries

2001 • 71 citations

Preventive effect of Y-27632, a selective Rho-kinase inhibitor, on ischemia/reperfusion-induced acute renal failure in rats

2004 • 43 citations

Searching new targets for anticancer drug design: The families of Ras and Rho GTPases and their effectors

2001 • 36 citations