Reactive oxygen species mediate TGF-β1-induced plasminogen activator inhibitor-1 upregulation in mesangial cells

Hyperglycemia-induced mitochondrial superoxide overproduction activates the hexosamine pathway and induces plasminogen activator inhibitor-1 expression by increasing Sp1 glycosylation

2000 • 1,096 citations

Effect of plasminogen activator (urokinase), plasmin, and thrombin on glycoprotein and collagenous components of basement membrane.

1981 • 587 citations

Reactive Oxygen Species-Regulated Signaling Pathways in Diabetic Nephropathy

2003 • 463 citations

Reactive oxygen species as glucose signaling molecules in mesangial cells cultured under high glucose

2000 • 312 citations

Reactive oxygen species (ROS) mediates the mitochondrial‐dependent apoptosis induced by transforming growth factor ß in fetal hepatocytes

2001 • 290 citations

Role of High Glucose-Induced Nuclear Factor-κB Activation in Monocyte Chemoattractant Protein-1 Expression by Mesangial Cells

2002 • 269 citations

Effect of plasminogen activator (urokinase), plasmin, and thrombin on glycoprotein and collagenous components of basement membrane

1982 • 226 citations

Hydrogen peroxide increases extracellular matrix mRNA through TGF-β in human mesangial cells

2001 • 215 citations

ECM degradation by cultured human mesangial cells is mediated by a PA/plasmin/MMP-2 cascade

1995 • 207 citations

Glomerular matrix accumulation is linked to inhibition of the plasmin protease system

1992 • 189 citations

Plasminogen activator inhibitor type 1 is a potential target in renal fibrogenesis

2000 • 183 citations

Requirement of Hydrogen Peroxide Generation in TGF-β1 Signal Transduction in Human Lung Fibroblast Cells: Involvement of Hydrogen Peroxide and Ca2+ in TGF-β1-Induced IL-6 Expression

2000 • 145 citations

Sequential effects of high glucose on mesangial cell transforming growth factor-β1 and fibronectin synthesis

1998 • 133 citations

A mutant, noninhibitory plasminogen activator inhibitor type 1 decreases matrix accumulation in experimental glomerulonephritis

2003 • 129 citations

TGF-β1-induced PAI-1 gene expression requires MEK activity and cell-to-substrate adhesion

2001 • 123 citations

Transforming Growth Factor-β Is a Potent Inhibitor of Extracellular Matrix Degradation by Cultured Human Mesangial Cells

1999 • 119 citations

A mutant, noninhibitory plasminogen activator inhibitor type 1 decreases matrix accumulation in experimental glomerulonephritis

2003 • 103 citations

Transforming growth factor beta 1-induced apoptosis in human ovarian carcinoma cells: protection by the antioxidant N-acetylcysteine and bcl-2.

1996 • 103 citations

Mesangial Matrix Modulation and Glomerulosclerosis

1999 • 101 citations

Hydrogen peroxide-mediated transcriptional induction of macrophage colony-stimulating factor by TGF-beta1.

1997 • 78 citations

Redox modulation of the pro-fibrogenic mediator plasminogen activator inhibitor-1 following ionizing radiation.

2001 • 73 citations

Transforming growth factor-β1 increases albumin permeability of isolated rat glomeruli via hydroxyl radicals

2000 • 70 citations

Cyclic Strain-Induced Plasminogen Activator Inhibitor-1 (PAI-1) Release from Endothelial Cells Involves Reactive Oxygen Species

1996 • 68 citations

Transforming growth factor-β in human glomerular injury

1997 • 59 citations

Transcriptional activation of matrix genes by transforming growth factor beta 1 in mesangial cells.

1993 • 52 citations

TGF-β-induced p38 activation is mediated by Rac1-regulated generation of reactive oxygen species in cultured human keratinocytes

2001 • 51 citations

Activation of p38MAPK by TGF‐β in fetal rat hepatocytes requires radical oxygen production, but is dispensable for cell death

2001 • 38 citations

Effect of TGF-beta 1 and TNF-alpha on the plasminogen system of rat proximal tubular epithelial cells.

1997 • 34 citations

The Effect of Transforming Growth Factor β1 on Mesangial Cell Fibronectin Synthesis: Increased Incorporation into the Extracellular Matrix and Reduced pI but No Effect on Alternative Splicing

1993 • 33 citations

Roles of RhoA and Phospholipase A2 in the Elevation of Intracellular H2O2 by Transforming Growth Factor-β in Swiss 3T3 Fibroblasts

1999 • 23 citations

Antisense targeting of c-fos transcripts inhibits serum- and TGF-?1-stimulated PAI-1 gene expression and directed motility in renal epithelial cells

2001 • 16 citations

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