Essential Role of Smad3 in Angiotensin II–Induced Vascular Fibrosis

TGF-β SIGNAL TRANSDUCTION

1998 • 7,582 citations

Direct binding of Smad3 and Smad4 to critical TGFbeta -inducible elements in the promoter of human plasminogen activator inhibitor-type 1gene

1998 • 1,763 citations

A mechanism of repression of TGFbeta / Smad signaling by oncogenic Ras

1999 • 1,004 citations

Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta

1999 • 890 citations

TGF-β Receptor Type II Deficiency Results in Defects of Yolk Sac Hematopoiesis and Vasculogenesis

1996 • 651 citations

Identification of Novel TGF-β/Smad Gene Targets in Dermal Fibroblasts using a Combined cDNA Microarray/Promoter Transactivation Approach

2001 • 628 citations

Smad2 role in mesoderm formation, left–right patterning and craniofacial development

1998 • 600 citations

Interdependent SMAD and JNK Signaling in Transforming Growth Factor-β-mediated Transcription

1999 • 534 citations

Functional Characterization of Transforming Growth Factor β Signaling in Smad2- and Smad3-deficient Fibroblasts

2001 • 397 citations

Stimulation of Type I Collagen Transcription in Human Skin Fibroblasts by TGF-β: Involvement of Smad 3

1999 • 388 citations

Angiotensin II and EGF receptor cross-talk in chronic kidney diseases: a new therapeutic approach

2005 • 333 citations

Angiotensin II Activates the Smad Pathway in Vascular Smooth Muscle Cells by a Transforming Growth Factor-β–Independent Mechanism

2005 • 314 citations

Advanced glycation end products activate Smad signaling via TGF‐β‐dependent and ‐independent mechanisms: implications for diabetic renal and vascular disease

2003 • 254 citations

p38 MAPK mediates fibrogenic signal through smad3 phosphorylation in rat myofibroblasts

2003 • 248 citations

Transforming Growth Factor-β Repression of Matrix Metalloproteinase-1 in Dermal Fibroblasts Involves Smad3

2001 • 247 citations

Recent advances in angiotensin II signaling

2002 • 239 citations

Induced disruption of the transforming growth factor beta type II receptor gene in mice causes a lethal inflammatory disorder that is transplantable

2002 • 235 citations

Alternatively Spliced Variant of Smad2 Lacking Exon 3

1999 • 235 citations

Signaling Mechanism of TGF-β1 in Prevention of Renal Inflammation

2005 • 233 citations

Modulation of Smad2-mediated Signaling by Extracellular Signal-regulated Kinase

2002 • 194 citations

Regression of Renal Vascular and Glomerular Fibrosis

2003 • 190 citations

Interaction between angiotensin II and Smad proteins in fibroblasts in failing heart and in vitro

2000 • 171 citations

Blood pressure-independent effect of angiotensin inhibition on vascular lesions of chronic renal failure

1992 • 166 citations

Inactivation of Smad-Transforming Growth Factor β Signaling by Ca²⁺-Calmodulin-Dependent Protein Kinase II

2000 • 161 citations

Deletion of Smad2 in Mouse Liver Reveals Novel Functions in Hepatocyte Growth and Differentiation

2005 • 154 citations

p38 MAPK mediates fibrogenic signal through Smad3 phosphorylation in rat myofibroblasts

2003 • 133 citations

Transgenic Mice Expressing a Dominant-Negative Mutant Type II Transforming Growth Factor-β Receptor Exhibit Impaired Mammary Development and Enhanced Mammary Tumor Formation

2003 • 129 citations

Reversal of Hypercholesterolemia in Low Density Lipoprotein Receptor Knockout Mice by Adenovirus-mediated Gene Transfer of the Very Low Density Lipoprotein Receptor

1996 • 129 citations

Mapping tissue angiotensin-converting enzyme and angiotensin AT1, AT2 and AT4 receptors

1998 • 129 citations

Cross-talk between the p42/p44 MAP Kinase and Smad Pathways in Transforming Growth Factor β1-induced Furin Gene Transactivation

2001 • 124 citations

Angiotensin II Stimulates Collagen Synthesis in Human Vascular Smooth Muscle Cells

1999 • 118 citations

Targeted Disruption of TGF-β–Smad3 Signaling Leads to Enhanced Neointimal Hyperplasia With Diminished Matrix Deposition in Response to Vascular Injury

2005 • 73 citations

Arterial Remodeling in Chronic Sinoaortic-Denervated Rats

2001 • 64 citations

Angiotensin II receptor blockade prevents microangiopathy and preserves diastolic function in the diabetic rat heart

2003 • 54 citations

Evidence for vascular macrophage migration inhibitory factor in destabilization of human atherosclerotic plaques

2004 • 52 citations

Progression and regression in renal vascular and glomerular fibrosis

2004 • 45 citations

Renal and Vascular Injury Induced by Exogenous Angiotensin II Is AT1 Receptor-Dependent

2001 • 39 citations

Altered Signaling and Regulatory Mechanisms of Apoptosis in Focal and Segmental Glomerulosclerosis

2001 • 35 citations