Glucagon-Like Peptide-1 and Exendin-4 Stimulate β-Cell Neogenesis in Streptozotocin-Treated Newborn Rats Resulting in Persistently Improved Glucose Homeostasis at Adult Age

Preserved incretin activity of glucagon-like peptide 1 [7-36 amide] but not of synthetic human gastric inhibitory polypeptide in patients with type-2 diabetes mellitus.

1993 • 1,579 citations

Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats.

1999 • 1,207 citations

The Glucagon-Like Peptides

1999 • 1,018 citations

Isolation and characterization of exendin-4, an exendin-3 analogue, from Heloderma suspectum venom. Further evidence for an exendin receptor on dispersed acini from guinea pig pancreas.

1992 • 912 citations

Expression cloning of the pancreatic beta cell receptor for the gluco-incretin hormone glucagon-like peptide 1.

1992 • 880 citations

Antidiabetogenic Effect of Glucagon-like Peptide-1 (7–36)amide in Normal Subjects and Patients with Diabetes Mellitus

1992 • 858 citations

Insulinotropin: glucagon-like peptide I (7-37) co-encoded in the glucagon gene is a potent stimulator of insulin release in the perfused rat pancreas.

1987 • 814 citations

Glucose intolerance but normal satiety in mice with a null mutation in the glucagon–like peptide 1 receptor gene

1996 • 771 citations

Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas.

2000 • 590 citations

Islet Pathology and the Pathogenesis of Type 1 and Type 2 Diabetes mellitus Revisited

1985 • 580 citations

Chronic Hyperglycemia Triggers Loss of Pancreatic β Cell Differentiation in an Animal Model of Diabetes

1999 • 551 citations

Glucagon-Like Peptides

1998 • 548 citations

Cloning and Functional Expression of the Human Islet GLP-1 Receptor: Demonstration That Exendin-4 Is an Agonist and Exendin-(9–39) an Antagonist of the Receptor

1993 • 533 citations

Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells

1999 • 405 citations

Hyperglycemia-induced beta-cell apoptosis in pancreatic islets of Psammomys obesus during development of diabetes.

1999 • 401 citations

Apoptosis Participates in the Remodeling of the Endocrine Pancreas in the Neonatal Rat*

1997 • 399 citations

Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells.

1999 • 326 citations

Responses of Neonatal Rat Islets to Streptozotocin: Limited B-Cell Regeneration and Hyperglycemia

1981 • 310 citations

Diabetogenic Effect of Streptozotocin in the Rat During the Perinatal Period

1974 • 232 citations

Chronic exposure of HIT cells to high glucose concentrations paradoxically decreases insulin gene transcription and alters binding of insulin gene regulatory protein.

1993 • 212 citations

Pancreatic Beta-cell growth and diabetes mellitus

1992 • 206 citations

Chemical diabetes in the adult rat as the spontaneous evolution of neonatal diabetes

1979 • 200 citations

Glucagon-like peptides

1998 • 191 citations

Glucagon-like peptide-1 can reverse the age-related decline in glucose tolerance in rats.

1997 • 174 citations

Minimal chronic hyperglycemia is a critical determinant of impaired insulin secretion after an incomplete pancreatectomy.

1988 • 172 citations

Initiation of Increased Pancreatic Islet Growth in Young Normoglycemic Mice (Umeå +/?)*

1999 • 153 citations

In vivo cell transformation: Neogenesis of beta cells from pancreatic ductal cells,

1995 • 143 citations

Beta-cell proliferation in normal and streptozotocin-treated newborn rats: site, dynamics and capacity

1994 • 142 citations

Glucose Insensitivity and Amino-acid Hypersensitivity of Insulin Release in Rats with Non-insulin-dependent Diabetes: A Study with the Perfused Pancreas

1983 • 136 citations

Experimental reduction of B‐cell mass: Implications for the pathogenesis of diabetes

1986 • 134 citations

Glucagon‐like peptide 1: A potent glycogenic hormone

1994 • 133 citations

Potent glycogenic effect of GLP-1(7?36)amide in rat skeletal muscle

1994 • 133 citations

Reduced Insulin, GLUT2, and IDX-1 in β-Cells After Partial Pancreatectomy

1997 • 131 citations

Accelerated Loss of Islet β Cells in Sucrose-Fed Goto-Kakizaki Rats, a Genetic Model of Non-Insulin-Dependent Diabetes Mellitus

1998 • 116 citations

Glucagon-like peptide-1(7-36) amide (GLP-1) enhances insulin-stimulated glucose metabolism in 3T3-L1 adipocytes: one of several potential extrapancreatic sites of GLP-1 action.

1994 • 114 citations

Identification of glucagon-like peptide 1 (GLP-1) actions essential for glucose homeostasis in mice with disruption of GLP-1 receptor signaling.

1998 • 109 citations

Islet cell neogenesis in the pancreas

1996 • 102 citations

Responses of neonatal rat islets to streptozotocin: limited B-cell regeneration and hyperglycemia

1981 • 91 citations

Histogenesis of the Endocrine pancreas in newborn rats after destruction by streptozotocin

1980 • 86 citations

The Incretin Notion and its Relevance to Diabetes

1993 • 82 citations

Pancreatic beta-cell regeneration after 48-h glucose infusion in mildly diabetic rats is not correlated with functional improvement.

1998 • 79 citations

Insulin Administration Enhances Growth of the β-Cell Mass in Streptozotocin-Treated Newborn Rats

1997 • 78 citations

Ultrastructural study of pancreatic B cell regeneration in newborn rats after destruction by streptozotocin

1982 • 64 citations

Preferential Reduction of Insulin Production in Mouse Pancreatic Islets Maintained in Culture after Streptozotocin Exposure*

1988 • 57 citations

Prior streptozotocin treatment does not inhibit pancreas regeneration after 90% pancreatectomy in rats

1999 • 50 citations

Glucose insensitivity and amino-acid hypersensitivity of insulin release in rats with non-insulin-dependent diabetes. A study with the perfused pancreas

1983 • 46 citations

In Vitro Restoration of Insulin Production in Islets from Adult Rats Treated Neonatally with Streptozotocin

1990 • 45 citations

In Vivo Cell Transformation: Neogenesis of Beta Cells from Pancreatic Ductal Cells

1995 • 43 citations

Preserved GLP-I Effects on Glycogen Synthase a Activity and Glucose Metabolism in Isolated Hepatocytes and Skeletal Muscle From Diabetic Rats

1997 • 39 citations

Limited B cell regeneration in a B cell deficient rat model: Studies with dexamethasone

1981 • 39 citations

Reduced insulin, GLUT2, and IDX-1 in beta-cells after partial pancreatectomy

1997 • 39 citations

Dynamics of Glucose-induced Insulin Release During the Spontaneous Remission of Streptozocin Diabetes Induced in the Newborn Rat

1985 • 35 citations

Preserved GLP-I effects on glycogen synthase a activity and glucose metabolism in isolated hepatocytes and skeletal muscle from diabetic rats

1997 • 18 citations

Insulin administration enhances growth of the beta-cell mass in streptozotocin-treated newborn rats

1997 • 17 citations

Dynamics of glucose-induced insulin release during the spontaneous remission of streptozocin diabetes induced in the newborn rat

1985 • 5 citations

Insulin secretion and glucose tolerance after islet transplantation in rats with noninsulin-dependent diabetes induced by neonatal streptozotocin

1997 • 4 citations

Insulin Secretion and Glucose Tolerance after Islet Transplantation in Rats with Noninsulin-Dependent Diabetes Induced by Neonatal Streptozotocin

1997 • 2 citations

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