Insulinotropic glucagon-like peptide 1 agonists stimulate expression of homeodomain protein IDX-1 and increase islet size in mouse pancreas.

A role for glucagon-like peptide-1 in the central regulation of feeding

1996 • 1,880 citations

Insulin-promoter-factor 1 is required for pancreas development in mice

1994 • 1,789 citations

PDX-1 is required for pancreatic outgrowth and differentiation of the rostral duodenum

1996 • 1,505 citations

A Family of cAMP-Binding Proteins That Directly Activate Rap1

1998 • 1,351 citations

Glucagon-like peptide 1 promotes satiety and suppresses energy intake in humans.

1998 • 1,338 citations

Exendin-4 stimulates both beta-cell replication and neogenesis, resulting in increased beta-cell mass and improved glucose tolerance in diabetic rats.

1999 • 1,207 citations

Pancreatic agenesis attributable to a single nucleotide deletion in the human IPF1 gene coding sequence

1997 • 1,107 citations

The Glucagon-Like Peptides

1999 • 1,018 citations

Developmental biology of the pancreas

1995 • 942 citations

Antidiabetogenic Effect of Glucagon-like Peptide-1 (7–36)amide in Normal Subjects and Patients with Diabetes Mellitus

1992 • 858 citations

Glucose intolerance but normal satiety in mice with a null mutation in the glucagon–like peptide 1 receptor gene

1996 • 771 citations

A Second Pathway for Regeneration of Adult Exocrine and Endocrine Pancreas: A Possible Recapitulation of Embryonic Development

1993 • 650 citations

Expression of murine STF-1, a putative insulin gene transcription factor, in β cells of pancreas, duodenal epithelium and pancreatic exocrine and endocrine progenitors during ontogeny

1995 • 562 citations

Chronic Hyperglycemia Triggers Loss of Pancreatic β Cell Differentiation in an Animal Model of Diabetes

1999 • 551 citations

Glucagon-Like Peptides

1998 • 548 citations

Glucagon-like peptide-1 promotes DNA synthesis, activates phosphatidylinositol 3-kinase and increases transcription factor pancreatic and duodenal homeobox gene 1 (PDX-1) DNA binding activity in beta (INS-1)-cells

1999 • 405 citations

The homeodomain protein IDX-1 increases after an early burst of proliferation during pancreatic regeneration.

1999 • 339 citations

Glucagon-like peptide 1 and exendin-4 convert pancreatic AR42J cells into glucagon- and insulin-producing cells.

1999 • 326 citations

Fatty Acids Decrease IDX-1 Expression in Rat Pancreatic Islets and Reduce GLUT2, Glucokinase, Insulin, and Somatostatin Levels

1997 • 286 citations

Maturity-onset diabetes of the young: clinical heterogeneity explained by genetic heterogeneity

1998 • 281 citations

Missense mutations in the insulin promoter factor-1 gene predispose to type 2 diabetes

1999 • 258 citations

Hepatocyte Nuclear Factor 3β is Involved in Pancreatic β-Cell-Specific Transcription of the pdx-1 Gene

1997 • 256 citations

Transcribing pancreas.

1998 • 252 citations

Glucose Stimulates Translocation of the Homeodomain Transcription Factor PDX1 from the Cytoplasm to the Nucleus in Pancreatic β-Cells

1999 • 219 citations

The Glucagon-Like Peptides

1999 • 218 citations

Pancreatic Glucagon-Like Peptide-1 Receptor Couples to Multiple G Proteins and Activates Mitogen-Activated Protein Kinase Pathways in Chinese Hamster Ovary Cells*

1999 • 202 citations

Once daily injection of exendin-4 to diabetic mice achieves long-term beneficial effects on blood glucose concentrations

1999 • 192 citations

A second pathway for regeneration of adult exocrine and endocrine pancreas. A possible recapitulation of embryonic development

1993 • 191 citations

Glucagon-like peptides

1998 • 191 citations

Glucagon-like peptide-1 can reverse the age-related decline in glucose tolerance in rats.

1997 • 174 citations

Insulin promoter factor-1 gene mutation linked to early-onset type 2 diabetes mellitus directs expression of a dominant negative isoprotein.

1998 • 173 citations

Initiation of Increased Pancreatic Islet Growth in Young Normoglycemic Mice (Umeå +/?)*

1999 • 153 citations

The reduction of insulin gene transcription in HIT-T15 beta cells chronically exposed to high glucose concentration is associated with the loss of RIPE3b1 and STF-1 transcription factor expression.

1995 • 149 citations

GLP-1 action in L6 myotubes is via a receptor different from the pancreatic GLP-1 receptor

1998 • 136 citations

Reduced Insulin, GLUT2, and IDX-1 in β-Cells After Partial Pancreatectomy

1997 • 131 citations

A newly discovered role of transcription factors involved in pancreas development and the pathogenesis of diabetes mellitus.

1998 • 129 citations

Pancreatic β-Cell-specific Repression of Insulin Gene Transcription by CCAAT/Enhancer-binding Protein β

1997 • 123 citations

Differential expression of the insulin gene transcriptional repressor CCAAT/enhancer-binding protein beta and transactivator islet duodenum homeobox-1 in rat pancreatic beta cells during the development of diabetes mellitus.

1998 • 121 citations

Developmental Expression of the Homeodomain Protein IDX-1 in Mice Transgenic for an IDX-1 Promoter/lacZ Transcriptional Reporter1

1999 • 116 citations

Homeodomain Protein IDX-1

1997 • 109 citations

Glucose-dependent Translocation of Insulin Promoter Factor-1 (IPF-1) between the Nuclear Periphery and the Nucleoplasm of Single MIN6 β-Cells

1998 • 100 citations

Demonstration of Two Different Processes of β-Cell Regeneration in a New Diabetic Mouse Model Induced by Selective Perfusion of Alloxan

1997 • 84 citations

The Incretin Notion and its Relevance to Diabetes

1993 • 82 citations

Novel signal transduction and peptide specificity of glucagon-like peptide receptor in 3T3-L1 adipocytes

1997 • 79 citations

Pancreatic Glucagon-Like Peptide-1 Receptor Couples to Multiple G Proteins and Activates Mitogen-Activated Protein Kinase Pathways in Chinese Hamster Ovary Cells

1999 • 51 citations

Initiation of Increased Pancreatic Islet Growth in Young Normoglycemic Mice (Umea +/?)

1999 • 45 citations

Reconstitution of glucotoxic HIT-T15 cells with somatostatin transcription factor-1 partially restores insulin promoter activity.

1998 • 41 citations

Developmental Expression of the Homeodomain Protein IDX-1 in Mice Transgenic for an IDX-1 Promoter/lacZ Transcriptional Reporter

1999 • 35 citations